Results 1 to 10 of about 34,540,887 (194)
NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury [PDF]
Frontiers in Oncology, 2021 Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Jiao Xue +20 more
doaj +2 more sources
Nrf2 plays a critical role in the metabolic response during and after spaceflight
Communications Biology, 2021 Akira Uruno et al. report the volume of epidydimal white adipose tissue and plasma glycerophospholipid and sphingolipid levels in mice increase during spaceflight.
Akira Uruno +21 more
doaj +1 more source
Antioxidants, 2021 Colorectal cancer still has a high incidence and mortality rate, according to a report from the American Cancer Society. Colorectal cancer has a high prevalence in patients with inflammatory bowel disease.
Da-Young Lee +2 more
doaj +1 more source
The molecular biology and therapeutic potential of Nrf2 in leukemia
Cancer Cell International, 2022 NF-E2-related factor 2 (Nrf2) transcription factor has contradictory roles in cancer, which can act as a tumor suppressor or a proto-oncogene in different cell conditions (depending on the cell type and the conditions of the cell environment).
Atefeh Khodakarami +8 more
doaj +1 more source
Natural Product Communications, 2022 Ganoderma lucidum ( G. lucidum ) is one of the well-known mushrooms in China, which has G. lucidum polysaccharides (GLP) that have been widely studied for various biological activities, such as antioxidant, antitumor, antiinflammatory, antiviral ...
Zengenni Liang +6 more
doaj +1 more source
Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice. [PDF]
PLoS ONE, 2016 The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of hepatic Nrf2 activation in metabolic disease,
Sebastian Brachs +10 more
doaj +1 more source
Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells
Antioxidants, 2021 Nrf2 (nuclear factor erythroid 2 (NF-E2)-related factor 2) transcription factor is recognized for its pro-survival and cell protective role upon exposure to oxidative, chemical, or metabolic stresses.
Sara Mikac +6 more
doaj +1 more source
PLoS ONE, 2020 Procyandin A2 (PCA2) is a polyphenolic compound which is isolated from grape seeds. It has been reported that PCA2 exhibits antioxidative and anti-inflammatory effects, but its molecular mechanism is still poorly understood.
Qin-Qin Wang +10 more
doaj +1 more source
Marine Drugs, 2015 In this study, we examined the protective effects of porphyra-334 against UVA-irradiated cellular damage and elucidated the underlying mechanisms. Porphyra-334 prevented UVA-induced cell death and exhibited scavenging activities against intracellular ...
Jina Ryu, Mi-Jin Kwon, Taek-Jeong Nam
doaj +1 more source
Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation. [PDF]
PLoS ONE, 2009 Cigarette smoking is an important risk factor for atherosclerosis, a chronic inflammatory disease. However the underlying factors of this effect are unclear.
Ulisse Garbin +10 more
doaj +1 more source