Results 21 to 30 of about 34,540,887 (194)

Immunomodulatory Effects of Spherical Date Seed Pills Industrially Fabricated on RAW264.7 Cells

Foods, 2023
Dates have been demonstrated to display a variety of bioactivities and are rich in polyphenols. In this work, we assessed the underlying immunomodulatory effects of date seed polyphenol extracts that had been industrially encapsulated and fabricated into
Ibrahim Khalifa, Fahad K. Aldhafiri
doaj   +1 more source

Esculetin attenuates cerebral ischemia-reperfusion injury and protects neurons through Nrf2 activation in rats [PDF]

Brazilian Journal of Medical and Biological Research
Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a key transcription factor in the antioxidant response and is associated with various chronic diseases.
Zhe Zhang, Jiayun Zhang, Rui Shi, Tiantian Xu, Shiduo Wang, Junbiao Tian   +5 more
doaj   +1 more source

Environmental toxicity, redox signaling and lung inflammation:the role of glutathione [PDF]

, 2009
Glutathione (gamma-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular antioxidant thiol and is central to redox defense during oxidative stress.
Saibal K. Biswas, Biswas, Saibal K, Rahman, Irfan, Irfan Rahman   +3 more
core   +1 more source

Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2

Journal of Experimental & Clinical Cancer Research, 2012
Background Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear.
Zhang Lingmin, Wang Ning, Zhou Suna, Ye Wenguang, Jing Guixia, Zhang Mingxin   +5 more
doaj   +1 more source

Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role

Antioxidants, 2021
Chemoresistance represents the main obstacle to cancer treatment with both conventional and targeted therapy. Beyond specific molecular alterations, which can lead to targeted therapy, metabolic remodeling, including the control of redox status, plays an
Giuseppina Barrera, Marie Angele Cucci, Margherita Grattarola, Chiara Dianzani, Giuliana Muzio, Stefania Pizzimenti   +5 more
doaj   +1 more source

Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer

Antioxidants, 2023
Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution ...
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi   +6 more
doaj   +1 more source

Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells

Biological Research, 2019
Background Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target.
Jiangpei Zhao, Lerong Liu, Xia Li, Lingxiao Zhang, Jing Lv, Xueli Guo, Hui Chen, Tongfeng Zhao   +7 more
doaj   +1 more source

Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production

Antioxidants, 2020
The skin is constantly exposed to various types of chemical stresses that challenge the immune cells, leading to the activation of T cell-mediated hypersensitivity reactions including atopic dermatitis.
Ok-Kyung Yoo, Won Jun Choi, Young-Sam Keum   +2 more
doaj   +1 more source

NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB

Mediators of Inflammation, 2021
Nuclear factor E2-related factor 2 (NRF2) plays an anti-inflammatory role in several pathological processes, but its function in lipopolysaccharide- (LPS-) induced goat endometrial epithelial cells (gEECs) is still unknown.
Hongchu Bao, Qinglan Qu, Wei Zhang, Xinrong Wang, Jianye Fang, Jinwen Xue, Zhenteng Liu, Shunzhi He   +7 more
doaj   +1 more source

Dimethyl Itaconate Inhibits Melanogenesis in B16F10 Cells

Antioxidants, 2023
Itaconate is a metabolite produced to counteract and resolve pro-inflammatory responses when macrophages are challenged with intracellular or extracellular stimuli.
Bo-Yeong Yu, Hoang Hai Ngo, Won Jun Choi, Young-Sam Keum   +3 more
doaj   +1 more source