Results 41 to 50 of about 21,371 (169)

Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer

Antioxidants, 2023
Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution ...
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi   +6 more
doaj   +1 more source

NF-E2-related factor 2 over-expression in mesenchymal stem cells to improve cellular cardiomyoplasty

Electronic Physician, 2014
Myocardial infarction (MI) is the leading cause of death worldwide. Various therapeutic strategies have been introduced for MI treatment. In recent years, interest in utilizing mesenchymal stem cells (MSCs) for MI therapy has increased.
Mohammad Mohammadzadeh-Vardin, Mehryar Habibi Roudkenar   +1 more
doaj   +1 more source

Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role

Antioxidants, 2021
Chemoresistance represents the main obstacle to cancer treatment with both conventional and targeted therapy. Beyond specific molecular alterations, which can lead to targeted therapy, metabolic remodeling, including the control of redox status, plays an
Giuseppina Barrera, Marie Angele Cucci, Margherita Grattarola, Chiara Dianzani, Giuliana Muzio, Stefania Pizzimenti   +5 more
doaj   +1 more source

Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-κB Signaling Pathway [PDF]

Journal of Biological Chemistry, 2015
Inflammation is widely distributed in patients with Duchenne muscular dystrophy and ultimately leads to progressive deterioration of muscle function with chronic muscle damage, oxidative stress, and reduced oxidative capacity. NF-E2-related factor 2 (Nrf2) plays a critical role in defending against inflammation in different tissues via activation of ...
Cheng-Cao, Sun, Shu-Jun, Li, Cui-Li, Yang, Rui-Lin, Xue, Yong-Yong, Xi, Liang, Wang, Qian-Long, Zhao, De-Jia, Li   +7 more
openaire   +2 more sources

Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells

Biological Research, 2019
Background Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target.
Jiangpei Zhao, Lerong Liu, Xia Li, Lingxiao Zhang, Jing Lv, Xueli Guo, Hui Chen, Tongfeng Zhao   +7 more
doaj   +1 more source

Cardamonin Inhibits Oxazolone-Induced Atopic Dermatitis by the Induction of NRF2 and the Inhibition of Th2 Cytokine Production

Antioxidants, 2020
The skin is constantly exposed to various types of chemical stresses that challenge the immune cells, leading to the activation of T cell-mediated hypersensitivity reactions including atopic dermatitis.
Ok-Kyung Yoo, Won Jun Choi, Young-Sam Keum   +2 more
doaj   +1 more source

NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB

Mediators of Inflammation, 2021
Nuclear factor E2-related factor 2 (NRF2) plays an anti-inflammatory role in several pathological processes, but its function in lipopolysaccharide- (LPS-) induced goat endometrial epithelial cells (gEECs) is still unknown.
Hongchu Bao, Qinglan Qu, Wei Zhang, Xinrong Wang, Jianye Fang, Jinwen Xue, Zhenteng Liu, Shunzhi He   +7 more
doaj   +1 more source

Dimethyl Itaconate Inhibits Melanogenesis in B16F10 Cells

Antioxidants, 2023
Itaconate is a metabolite produced to counteract and resolve pro-inflammatory responses when macrophages are challenged with intracellular or extracellular stimuli.
Bo-Yeong Yu, Hoang Hai Ngo, Won Jun Choi, Young-Sam Keum   +3 more
doaj   +1 more source

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

Biomolecules, 2020
Aberrant hyperactivation of nuclear factor erythroid 2 (NF-E2) p45-related factor 2 (NRF2) is a common event in many tumour types and associates with resistance to therapy and poor patient prognosis; however, its relevance in colorectal tumours is not ...
Laura Torrente, Gunjit Maan, Asma Oumkaltoum Rezig, Jean Quinn, Angus Jackson, Andrea Grilli, Laura Casares, Ying Zhang, Evgeny Kulesskiy, Jani Saarela, Silvio Bicciato, Joanne Edwards, Albena T. Dinkova-Kostova, Laureano de la Vega   +13 more
doaj   +1 more source

Nrf2—A Molecular Target for Sepsis Patients in Critical Care

Biomolecules, 2020
The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response.
Sandra Gunne, Ulrike Heinicke, Michael J. Parnham, Volker Laux, Kai Zacharowski, Andreas von Knethen   +5 more
doaj   +1 more source