Results 41 to 50 of about 34,540,887 (194)
HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents [PDF]
, 2014 The NRF2 signalling cascade provides a primary response against electrophilic chemicals and oxidative stress. The activation of NRF2-signaling is anticipated to have adverse clinical consequences; NRF2 is activated in a number of cancers, additionally ...
A Kenneth MacLeod +17 more
core +2 more sources
Image_4_NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury.jpeg
, 2021 Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Wenjiong Sheng (11314161) +8 more
core +1 more source
Image_3_NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury.jpeg
, 2021 Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Wenjiong Sheng (11314161) +8 more
core +1 more source
Activation of Nrf2 protects against triptolide-induced hepatotoxicity. [PDF]
PLoS ONE, 2014 Triptolide, the major active component of Tripterygium wilfordii Hook f. (TWHF), has a wide range of pharmacological activities. However, the toxicities of triptolide, particularly the hepatotoxicity, limit its clinical application. The hepatotoxicity of
Jia Li +8 more
doaj +1 more source
Potential of isothiocyanate sulforaphane from broccoli to combat obesity and type 2 diabetes: involvement of NRF2 regulatory pathway [PDF]
The Ukrainian Biochemical JournalBiologically active food components are now considered to be remedies for the prevention and treatment of metabolic disorders of different etiology. The aim of this review was to analyze the current data on the application of isothiocyanate sulforaphane,
M. V. Ivanochko +2 more
doaj +1 more source
Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status [PDF]
Diabetes & Metabolism Journal, 2014 Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS ...
Jing Chen, Zhiguo Zhang, Lu Cai
doaj +1 more source
Redox Biology, 2020 Controlling inflammation is critical for preventing many diseases including cancer, autoimmune disorders and hypersensitivity reactions. NF-E2-related factor 2 (Nrf2) is a key transcription factor that controls the cellular antioxidant and cytoprotective
Jonathan Muri +4 more
doaj +1 more source
Stretch Causes Cell Stress and the Downregulation of Nrf2 in Primary Amnion Cells
Biomolecules, 2022 Nuclear-factor-E2-related factor 2 (Nrf2) is a key transcription factor for the regulation of cellular responses to cellular stress and inflammation, and its expression is significantly lower after spontaneous term labor in human fetal membranes ...
Justin Gary Padron +3 more
doaj +1 more source
Advanced Science, EarlyView.CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu +9 more
wiley +1 more source
Animal Research and One Health, EarlyView.Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian +8 more
wiley +1 more source