Results 51 to 60 of about 21,371 (169)

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

Redox Biology, 2018
Non-exudative age-related macular degeneration (AMD) is mainly caused by the accumulation of lipofuscin and drusen on the retinal pigment epithelium (RPE).
Yuichi Saito, Yoshiki Kuse, Yuki Inoue, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa   +5 more
doaj   +1 more source

Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-κB/MAPK signalling pathways and activating the Nrf2 signalling pathway

Ecotoxicology and Environmental Safety, 2021
Betulinic acid (BA), a pentacyclic triterpenoid, has been associated with several biological effects, such as antioxidant, anti-inflammatory and antiviral activities.
Zhaoping Ou, Lijuan Zhu, Chenglong Huang, Chaoyang Ma, Li Kong, Xing Lin, Xinyu Gao, Lin Huang, Lixin Wen, Zengenni Liang, Zhihang Yuan, Jing Wu, Jine Yi   +12 more
doaj   +1 more source

Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status [PDF]

Diabetes & Metabolism Journal, 2014
Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS ...
Jing Chen, Zhiguo Zhang, Lu Cai
doaj   +1 more source

Potential of isothiocyanate sulforaphane from broccoli to combat obesity and type 2 diabetes: involvement of NRF2 regulatory pathway [PDF]

The Ukrainian Biochemical Journal
Biologically active food components are now considered to be remedies for the prevention and treatment of metabolic disorders of different etiology. The aim of this review was to analyze the current data on the application of isothiocyanate sulforaphane,
M. V. Ivanochko, M. M. Bayliak, V. I. Lushchak   +2 more
doaj   +1 more source

Activation of Nrf2 protects against triptolide-induced hepatotoxicity. [PDF]

PLoS ONE, 2014
Triptolide, the major active component of Tripterygium wilfordii Hook f. (TWHF), has a wide range of pharmacological activities. However, the toxicities of triptolide, particularly the hepatotoxicity, limit its clinical application. The hepatotoxicity of
Jia Li, Feihai Shen, Cuiwen Guan, Wenwen Wang, Xiaozhe Sun, Xinlu Fu, Min Huang, Jing Jin, Zhiying Huang   +8 more
doaj   +1 more source

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. [PDF]

Proceedings of the National Academy of Sciences, 1994
Hypersensitive site 2 located in the beta-globin locus control region confers high levels of expression to the genes of the beta-globin cluster. A tandem repeat of the consensus sequence for the transcription factors AP1 and NF-E2 (activating protein 1 and nuclear factor erythroid 2, respectively) is present within hypersensitive site 2 and is ...
MOI, PAOLO, Chan K, Asunis I, Cao A, Kan YW   +4 more
openaire   +3 more sources

Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose

Redox Biology, 2020
Controlling inflammation is critical for preventing many diseases including cancer, autoimmune disorders and hypersensitivity reactions. NF-E2-related factor 2 (Nrf2) is a key transcription factor that controls the cellular antioxidant and cytoprotective
Jonathan Muri, Helene Wolleb, Petr Broz, Erick M. Carreira, Manfred Kopf   +4 more
doaj   +1 more source

Stretch Causes Cell Stress and the Downregulation of Nrf2 in Primary Amnion Cells

Biomolecules, 2022
Nuclear-factor-E2-related factor 2 (Nrf2) is a key transcription factor for the regulation of cellular responses to cellular stress and inflammation, and its expression is significantly lower after spontaneous term labor in human fetal membranes ...
Justin Gary Padron, Nainoa D. Norman Ing, Po’okela K. Ng, Claire E. Kendal-Wright   +3 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source