Results 31 to 40 of about 30,847 (205)

Fisetin Inhibits Osteoclastogenesis Through Prevention of RANKL-Induced ROS Production by Nrf2-Mediated Up-regulation of Phase II Antioxidant Enzymes

Journal of Pharmacological Sciences, 2013
.: Osteoclasts (OCLs) are multinucleated bone-resorbing cells that are differentiated by stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor.
Eiko Sakai, Megumi Shimada-Sugawara, Yu Yamaguchi, Hiroshi Sakamoto, Reiko Fumimoto, Yutaka Fukuma, Kazuhisa Nishishita, Kuniaki Okamoto, Takayuki Tsukuba   +8 more
doaj   +1 more source

Immunomodulatory Effects of Spherical Date Seed Pills Industrially Fabricated on RAW264.7 Cells

Foods, 2023
Dates have been demonstrated to display a variety of bioactivities and are rich in polyphenols. In this work, we assessed the underlying immunomodulatory effects of date seed polyphenol extracts that had been industrially encapsulated and fabricated into
Ibrahim Khalifa, Fahad K. Aldhafiri
doaj   +1 more source

Ultraviolet A Irradiation Induces NF-E2-Related Factor 2 Activation in Dermal Fibroblasts: Protective Role in UVA-Induced Apoptosis [PDF]

, 2005
Ultraviolet (UV) radiation is one of the most important environmental factors involved in the pathogenesis of skin aging and cancer. Many harmful effects of UV radiation are associated with the generation of reactive oxygen species, and cellular ...
Banno Tomohiro, Hirota Ayako, Itoh Ken, Kawachi Yasuhiro, Nakamura Yasuhiro, Otsuka Fujio, Takahashi Takenori, Xu Xuezhu, Yamamoto Masayuki, 川内 康弘   +9 more
core   +1 more source

Esculetin attenuates cerebral ischemia-reperfusion injury and protects neurons through Nrf2 activation in rats [PDF]

Brazilian Journal of Medical and Biological Research
Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a key transcription factor in the antioxidant response and is associated with various chronic diseases.
Zhe Zhang, Jiayun Zhang, Rui Shi, Tiantian Xu, Shiduo Wang, Junbiao Tian   +5 more
doaj   +1 more source

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y., Kankia, Ibrahim H., Langdon, Simon P., Paramasivan, Poornima   +3 more
core   +3 more sources

Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2

Journal of Experimental & Clinical Cancer Research, 2012
Background Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear.
Zhang Lingmin, Wang Ning, Zhou Suna, Ye Wenguang, Jing Guixia, Zhang Mingxin   +5 more
doaj   +1 more source

Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer

Antioxidants, 2023
Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution ...
Somayyeh Ghareghomi, Faezeh Moosavi-Movahedi, Luciano Saso, Mehran Habibi-Rezaei, Ali Khatibi, Jun Hong, Ali A. Moosavi-Movahedi   +6 more
doaj   +1 more source

Loss of Nrf2 abrogates the protective effect of Keap1 down regulation in a preclinical model of cutaneous squamous cell carcinoma [PDF]

, 2016
Cutaneous squamous cell carcinomas (cSCC) are the most common and highly mutated human malignancies, challenging identification of driver mutations and targeted therapies.
A Enomoto, A Kaulmann, A Kobayashi, A Orthwein, A Svobodova, AL Eggler, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, C Boesch-Saadatmandi, C Cavin, C Xu, D Ren, DD Zhang, DF Lee, EV Knatko, F Rolfs, GM DeNicola, HJ Prochaska, J Ma, K Itoh, K Itoh, K Le Gal, K Taguchi, M Marin-Kuan, M McMahon, M McMahon, M Ramos-Gomez, M Schafer, P Talalay, S Durinck, S Tao, S Vartanian, SB Cullinan, T Suzuki, TW Kensler, VI Sayin, WH Habig, Y Mitsuishi   +39 more
core   +2 more sources

NF-E2-related factor 2 over-expression in mesenchymal stem cells to improve cellular cardiomyoplasty

Electronic Physician, 2014
Myocardial infarction (MI) is the leading cause of death worldwide. Various therapeutic strategies have been introduced for MI treatment. In recent years, interest in utilizing mesenchymal stem cells (MSCs) for MI therapy has increased.
Mohammad Mohammadzadeh-Vardin, Mehryar Habibi Roudkenar   +1 more
doaj   +1 more source

Sulforaphane Attenuates Muscle Inflammation in Dystrophin-deficient mdx Mice via NF-E2-related Factor 2 (Nrf2)-mediated Inhibition of NF-κB Signaling Pathway [PDF]

Journal of Biological Chemistry, 2015
Inflammation is widely distributed in patients with Duchenne muscular dystrophy and ultimately leads to progressive deterioration of muscle function with chronic muscle damage, oxidative stress, and reduced oxidative capacity. NF-E2-related factor 2 (Nrf2) plays a critical role in defending against inflammation in different tissues via activation of ...
Cheng-Cao, Sun, Shu-Jun, Li, Cui-Li, Yang, Rui-Lin, Xue, Yong-Yong, Xi, Liang, Wang, Qian-Long, Zhao, De-Jia, Li   +7 more
openaire   +2 more sources