Results 31 to 40 of about 34,540,887 (194)

Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor [PDF]

, 2007
Triphlorethol-A, phlorotannin found in Ecklonia cava, induced heme oxygenase-1 (HO-1) expression at mRNA and protein levels, leading to increased HO-1 activity.
Kang, Kyoung Ah, Chung, Myung Hee, Park, Jae Woo, Lee, Nam Ho, Hyun, Jin Won, Lee, Kyoung Hwa, Surh, Young Joon, Na, Hye Kyung, You, Ho Jin   +8 more
core   +1 more source

Nrf2—A Molecular Target for Sepsis Patients in Critical Care

Biomolecules, 2020
The transcription factor NF-E2 p45-related factor 2 (Nrf2) is an established master regulator of the anti-oxidative and detoxifying cellular response.
Sandra Gunne, Ulrike Heinicke, Michael J. Parnham, Volker Laux, Kai Zacharowski, Andreas von Knethen   +5 more
doaj   +1 more source

Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids [PDF]

, 2014
The transcription factor Nrf2 protects against a number of experimental pathologies, and is a promising therapeutic target. The clinical investigation of a potent Nrf2-inducing agent, the triterpenoid (TP) bardoxolone methyl (BARD), was recently halted ...
Lister, Adam, Shelton, Luke M., Kratschmar, Denise V., Copple, Ian M., Park, B. Kevin, Goldring, Christopher E., Honda, Tadashi, Odermatt, Alex, Walsh, Joanne, Dinkova-Kostova, Albena T.; id_orcid, Dinkova-Kostova, Albena T.   +10 more
core   +1 more source

Image_2_NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury.jpeg

, 2021
Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Wenjiong Sheng (11314161), Chenxiao Yu (7308917), Wei Mo (59016), Jiao Xue (713875), Zhicheng Tang (7010534), Yiting Tang (2295307), Yang Jiao (147576), Wei Zhu (23646), Jianping Cao (41543)   +8 more
core   +1 more source

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

Biomolecules, 2020
Aberrant hyperactivation of nuclear factor erythroid 2 (NF-E2) p45-related factor 2 (NRF2) is a common event in many tumour types and associates with resistance to therapy and poor patient prognosis; however, its relevance in colorectal tumours is not ...
Laura Torrente, Gunjit Maan, Asma Oumkaltoum Rezig, Jean Quinn, Angus Jackson, Andrea Grilli, Laura Casares, Ying Zhang, Evgeny Kulesskiy, Jani Saarela, Silvio Bicciato, Joanne Edwards, Albena T. Dinkova-Kostova, Laureano de la Vega   +13 more
doaj   +1 more source

Image_1_NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury.jpeg

, 2021
Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Wenjiong Sheng (11314161), Chenxiao Yu (7308917), Wei Mo (59016), Jiao Xue (713875), Zhicheng Tang (7010534), Yiting Tang (2295307), Yang Jiao (147576), Wei Zhu (23646), Jianping Cao (41543)   +8 more
core   +1 more source

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

Redox Biology, 2018
Non-exudative age-related macular degeneration (AMD) is mainly caused by the accumulation of lipofuscin and drusen on the retinal pigment epithelium (RPE).
Yuichi Saito, Yoshiki Kuse, Yuki Inoue, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa   +5 more
doaj   +1 more source

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A.   +6 more
core   +1 more source

Image_5_NF-E2-Related Factor 2 (Nrf2) Ameliorates Radiation-Induced Skin Injury.jpeg

, 2021
Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage is the major causes of RISI.
Wenjiong Sheng (11314161), Chenxiao Yu (7308917), Wei Mo (59016), Jiao Xue (713875), Zhicheng Tang (7010534), Yiting Tang (2295307), Yang Jiao (147576), Wei Zhu (23646), Jianping Cao (41543)   +8 more
core   +1 more source

Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-κB/MAPK signalling pathways and activating the Nrf2 signalling pathway

Ecotoxicology and Environmental Safety, 2021
Betulinic acid (BA), a pentacyclic triterpenoid, has been associated with several biological effects, such as antioxidant, anti-inflammatory and antiviral activities.
Zhaoping Ou, Lijuan Zhu, Chenglong Huang, Chaoyang Ma, Li Kong, Xing Lin, Xinyu Gao, Lin Huang, Lixin Wen, Zengenni Liang, Zhihang Yuan, Jing Wu, Jine Yi   +12 more
doaj   +1 more source