PLoS ONE, 2020 Procyandin A2 (PCA2) is a polyphenolic compound which is isolated from grape seeds. It has been reported that PCA2 exhibits antioxidative and anti-inflammatory effects, but its molecular mechanism is still poorly understood.
Qin-Qin Wang +10 more
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Marine Drugs, 2015 In this study, we examined the protective effects of porphyra-334 against UVA-irradiated cellular damage and elucidated the underlying mechanisms. Porphyra-334 prevented UVA-induced cell death and exhibited scavenging activities against intracellular ...
Jina Ryu, Mi-Jin Kwon, Taek-Jeong Nam
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Laminar Flow Activation of ERK5 Protein in Vascular Endothelium Leads to Atheroprotective Effect via NF-E2-related Factor 2 (Nrf2) Activation [PDF]
Journal of Biological Chemistry, 2012 Laminar flow protects from atherosclerosis in endothelium.Laminar flow induces Nrf2 activation dependent on ERK5 activation, leading to up-regulation of downstream genes of Nrf2.ERK5 requires Nrf2 activation to exert cytoprotective effect on HUVEC. ERK5 inhibitor BIX02189 regulates Nrf2 activation in vivo.Identifying ERK5 as a molecular target for ...
Miso, Kim +5 more
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Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation. [PDF]
PLoS ONE, 2009 Cigarette smoking is an important risk factor for atherosclerosis, a chronic inflammatory disease. However the underlying factors of this effect are unclear.
Ulisse Garbin +10 more
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PLoS ONE, 2019 Several reports indicate crosstalk between the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and estrogen, which has a protective effect in colorectal cancer (CRC).
Chin-Hee Song +4 more
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Journal of Pharmacological Sciences, 2013 .: Osteoclasts (OCLs) are multinucleated bone-resorbing cells that are differentiated by stimulation with receptor activator of nuclear factor kappa-B ligand (RANKL) and macrophage colony-stimulating factor.
Eiko Sakai +8 more
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Immunomodulatory Effects of Spherical Date Seed Pills Industrially Fabricated on RAW264.7 Cells
Foods, 2023 Dates have been demonstrated to display a variety of bioactivities and are rich in polyphenols. In this work, we assessed the underlying immunomodulatory effects of date seed polyphenol extracts that had been industrially encapsulated and fabricated into
Ibrahim Khalifa, Fahad K. Aldhafiri
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Esculetin attenuates cerebral ischemia-reperfusion injury and protects neurons through Nrf2 activation in rats [PDF]
Brazilian Journal of Medical and Biological ResearchNuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a key transcription factor in the antioxidant response and is associated with various chronic diseases.
Zhe Zhang +5 more
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Sulforaphane Activates Brain-Derived Neurotrophic Factor (BDNF) Transcription by NF-E2-Related factor-2 (Nrf2), Showing Prevention Effects on the Microglial of Stressed Mice [PDF]
, 2020 Abstract Background: Accumulating evidence suggested that sulforaphane (SFN) showed prevention effects in stressed mice by activating the NF-E2-related factor-2 (Nrf2). However, the mechanism remains poorly understood. The present study aimed to investigate whether the prevention effects of SFN in stressed mice by activating brain-derived ...
Rui Tang +8 more
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Propofol induces proliferation and invasion of gallbladder cancer cells through activation of Nrf2
Journal of Experimental & Clinical Cancer Research, 2012 Background Propofol is one of the most commonly used intravenous anaesthetic agents during cancer resection surgery, but the effect of propofol on gallbladder cancer is not clear.
Zhang Lingmin +5 more
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