Results 11 to 20 of about 30,847 (205)

Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice. [PDF]

PLoS ONE, 2016
The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of hepatic Nrf2 activation in metabolic disease,
Sebastian Brachs, Angelika F Winkel, James Polack, Hui Tang, Maria Brachs, Daniel Margerie, Bodo Brunner, Kerstin Jahn-Hofmann, Hartmut Ruetten, Joachim Spranger, Dieter Schmoll   +10 more
doaj   +6 more sources

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases [PDF]

Nature Reviews Drug Discovery, 2019
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), are critical in the maintenance of redox, metabolic and protein ...
Attucks, Otis C., Cousin, Sharon P., Cuadrado, Antonio, Dinkova-Kostova, Albena, Franklin, Stephen, Hayes, John, Kensler, Thomas W., Levonen, Anna-Liisa, Rojo, Ana I., Rumsey, William L., Wells, Geoffrey   +10 more
core   +4 more sources

NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]

, 2017
NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L., Deeni, Yusuf Y., Hamza Kankia, Ibrahim, Khalil, Hilal S., Langdon, Simon P., Moult, Peter R.   +5 more
core   +24 more sources

Nrf2 plays a critical role in the metabolic response during and after spaceflight

Communications Biology, 2021
Akira Uruno et al. report the volume of epidydimal white adipose tissue and plasma glycerophospholipid and sphingolipid levels in mice increase during spaceflight.
Akira Uruno, Daisuke Saigusa, Takafumi Suzuki, Akane Yumoto, Tomohiro Nakamura, Naomi Matsukawa, Takahiro Yamazaki, Ristumi Saito, Keiko Taguchi, Mikiko Suzuki, Norio Suzuki, Akihito Otsuki, Fumiki Katsuoka, Eiji Hishinuma, Risa Okada, Seizo Koshiba, Yoshihisa Tomioka, Ritsuko Shimizu, Masaki Shirakawa, Thomas W. Kensler, Dai Shiba, Masayuki Yamamoto   +21 more
doaj   +1 more source

Nrf2b, Novel Zebrafish Paralog of Oxidant-responsive Transcription Factor NF-E2-related Factor 2 (NRF2) [PDF]

Journal of Biological Chemistry, 2012
NF-E2-related factor 2 (NRF2; also called NFE2L2) and related NRF family members regulate antioxidant defenses by activating gene expression via antioxidant response elements (AREs), but their roles in embryonic development are not well understood. We report here that zebrafish (Danio rerio), an important developmental model species, possesses six nrf ...
Alicia R, Timme-Laragy, Sibel I, Karchner, Diana G, Franks, Matthew J, Jenny, Rachel C, Harbeitner, Jared V, Goldstone, Andrew G, McArthur, Mark E, Hahn   +7 more
openaire   +2 more sources

CR6-interacting Factor 1 (CRIF1) Regulates NF-E2-related Factor 2 (NRF2) Protein Stability by Proteasome-mediated Degradation [PDF]

Journal of Biological Chemistry, 2010
Free radicals generated by oxidative stress cause damage that can contribute to numerous chronic diseases. Mammalian cells respond to this damage by increased transcription of cytoprotective phase II genes, which are regulated by NRF2. Previously, it has been shown that NRF2 protein levels increase after oxidative stress because its negative regulator,
Kang, Hyo Jin, Hong, Young Bin, Kim, Hee Jeong, Bae, Insoo   +3 more
openaire   +2 more sources

Role of Oxidative Stress and Nrf2/KEAP1 Signaling in Colorectal Cancer: Mechanisms and Therapeutic Perspectives with Phytochemicals

Antioxidants, 2021
Colorectal cancer still has a high incidence and mortality rate, according to a report from the American Cancer Society. Colorectal cancer has a high prevalence in patients with inflammatory bowel disease.
Da-Young Lee, Moon-Young Song, Eun-Hee Kim   +2 more
doaj   +1 more source

The molecular biology and therapeutic potential of Nrf2 in leukemia

Cancer Cell International, 2022
NF-E2-related factor 2 (Nrf2) transcription factor has contradictory roles in cancer, which can act as a tumor suppressor or a proto-oncogene in different cell conditions (depending on the cell type and the conditions of the cell environment).
Atefeh Khodakarami, Sara Adibfar, Vahid Karpisheh, Shiva Abolhasani, Pooya Jalali, Hamed Mohammadi, Jamshid Gholizadeh Navashenaq, Mohammad Hojjat-Farsangi, Farhad Jadidi-Niaragh   +8 more
doaj   +1 more source

Activation of mouse Pi-class glutathione S-transferase gene by Nrf2(NF-E2-related factor 2) and androgen [PDF]

Biochemical Journal, 2002
The Pi-class glutathione S-transferases (GSTs) play pivotal roles in the detoxification of xenobiotics, carcinogenesis and drug resistance. The mechanisms of regulation of these genes during drug induction and carcinogenesis are yet to be elucidated. Recently, Nrf2 (NF-E2-related factor 2; a bZip-type transcription factor) knockout mice were shown to ...
Hiromi, Ikeda, Mohamed S, Serria, Ikuko, Kakizaki, Ichiro, Hatayama, Kimihiko, Satoh, Shigeki, Tsuchida, Masami, Muramatsu, Shinzo, Nishi, Masaharu, Sakai   +8 more
openaire   +2 more sources

New Mechanistic Insight into the Protective Effects of Polysaccharides Against Palmitic Acid-Induced Cell Damage in Porcine Intestinal Epithelial Cell Line IPEC-J2

Natural Product Communications, 2022
Ganoderma lucidum ( G. lucidum ) is one of the well-known mushrooms in China, which has G. lucidum polysaccharides (GLP) that have been widely studied for various biological activities, such as antioxidant, antitumor, antiinflammatory, antiviral ...
Zengenni Liang, Zhi-Hang Yuan, Yan Wang, Zhong-Hua Du, Jia-Jing Guo, Ling-Li Xia, Yang Shan   +6 more
doaj   +1 more source