Stem Cell Reports, 2017 Nuclear factor erythroid-derived 2 (NF-E2) has been associated with megakaryocyte maturation and platelet production. Recently, an increased in NF-E2 activity has been implicated in myeloproliferative neoplasms.
Alessandro Di Tullio +4 more
doaj +1 more source
Bromodomain and Extraterminal Proteins Suppress NF-E2–Related Factor 2–Mediated Antioxidant Gene Expression [PDF]
The Journal of Immunology, 2014 Abstract Oxidative stress, a pathogenetic factor in many conditions, including chronic obstructive pulmonary disease, arises due to accumulation of reactive oxygen species and defective antioxidant defenses in the lungs. The latter is due, at least in part, to impaired activation of NF-E2–related factor 2 (Nrf2), a transcription factor ...
Charalambos, Michaeloudes +6 more
openaire +2 more sources
Cinnamaldehyde Prevents Endothelial Dysfunction Induced by High Glucose by Activating Nrf2
Cellular Physiology and Biochemistry, 2015 Background/Aims: It is well documented that hyperglycemia-induced oxidative stress is an important causative factor of endothelial dysfunction. Cinnamaldehyde (CA) is a key flavor compound in cinnamon essential oil that can enhance the antioxidant ...
Fang Wang +8 more
doaj +1 more source
Ultraviolet A Irradiation Induces NF-E2-Related Factor 2 Activation in Dermal Fibroblasts: Protective Role in UVA-Induced Apoptosis [PDF]
, 2005 Ultraviolet (UV) radiation is one of the most important environmental factors involved in the pathogenesis of skin aging and cancer. Many harmful effects of UV radiation are associated with the generation of reactive oxygen species, and cellular ...
Banno Tomohiro +9 more
core +1 more source
Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role
Antioxidants, 2021 Chemoresistance represents the main obstacle to cancer treatment with both conventional and targeted therapy. Beyond specific molecular alterations, which can lead to targeted therapy, metabolic remodeling, including the control of redox status, plays an
Giuseppina Barrera +5 more
doaj +1 more source
Anti-inflammatory effect of supercritical extract and its constituents from Ishige okamurae [PDF]
, 2016 The anti-inflammatory properties of the supercritical fluid extract of Ishige okamurae (SFEIO) on lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages.
Ahn, Ginnae +12 more
core +1 more source
Expression of Nuclear Factor Erythroid 2 Protein in Malignant Cutaneous Tumors
Archives of Plastic Surgery, 2014 Background Reactive oxygen species (ROS) damages cell molecules, and modifies cell signaling. The nuclear factor E2-related factor (Nrf2) is a critical transcription regulator, which protects cells against oxidative damage.
Chang Yong Choi +10 more
doaj +1 more source
Asian Pacific Journal of Tropical Biomedicine, 2020 Objective: To evaluate the effect of standardized extract of Centella asiatica ECa 233 on inflammatory mediator production through cyclooxygenase-2 (COX-2), extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor-κB (NF-κB) pathway in ...
Furoida Moolsap +5 more
doaj +1 more source
Chronic Activation of Hepatic Nrf2 Has No Major Effect on Fatty Acid and Glucose Metabolism in Adult Mice [PDF]
, 2016 The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of hepatic Nrf2 activation in metabolic disease,
Brachs, Maria +10 more
core +3 more sources
Regulation of NF-E2-Related Factor 2 Signaling for Cancer Chemoprevention: Antioxidant Coupled with Antiinflammatory [PDF]
Antioxidants & Redox Signaling, 2010 Cancer chemoprevention is a process of using either natural or synthetic compounds to reduce the risk of developing cancer. Observations that NF-E2-related factor 2 (Nrf2)-deficient mice lack response to some chemopreventive agents point to the important role of Nrf2 in chemoprevention.
Rong, Hu +3 more
openaire +2 more sources