Results 21 to 30 of about 34,567,041 (234)
Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells
Biological Research, 2019 Background Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target.
Jiangpei Zhao +7 more
doaj +1 more source
Antioxidants, 2020 The skin is constantly exposed to various types of chemical stresses that challenge the immune cells, leading to the activation of T cell-mediated hypersensitivity reactions including atopic dermatitis.
Ok-Kyung Yoo +2 more
doaj +1 more source
Journal of Lipid Research, 2011 Oxidized phospholipids (OxPLs) are increasingly recognized as pleiotropic lipid mediators demonstrating a variety of biological activities. In particular, OxPLs induce electrophilic stress response and stimulate expression of NF-E2-related factor 2 (NRF2)
Taras Afonyushkin +3 more
doaj +1 more source
Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]
, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival ...
Biddlestone, John +4 more
core +1 more source
The nuclear factor E2-related factor 2 and age-related macular degeneration
, 2022 After the discovery of anti-vascular endothelial growth factor agents as treatment of wet age-related macular degeneration, the number of studies with the objective to understand the molecular mechanisms involved in the age-re lated macular degeneration ...
Ana Lúcia dos Anjos Ferreira (12684654) +3 more
core +1 more source
Nrf2 plays a critical role in the metabolic response during and after spaceflight
Communications Biology, 2021 Akira Uruno et al. report the volume of epidydimal white adipose tissue and plasma glycerophospholipid and sphingolipid levels in mice increase during spaceflight.
Akira Uruno +21 more
doaj +1 more source
Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor [PDF]
, 2007 Triphlorethol-A, phlorotannin found in Ecklonia cava, induced heme oxygenase-1 (HO-1) expression at mRNA and protein levels, leading to increased HO-1 activity.
Kang, Kyoung Ah +8 more
core +1 more source
The nuclear factor E2-related factor 2 and age-related macular degeneration
, 2023 After the discovery of anti-vascular endothelial growth factor agents as treatment of wet age-related macular degeneration, the number of studies with the objective to understand the molecular mechanisms involved in the age-re lated macular degeneration ...
Ana Lúcia dos Anjos Ferreira (12684654) +3 more
core +1 more source
The Relationship between Nrf2 and HO-1 with the Severity of COVID-19 Disease
Medicina, 2022 Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) have significant roles in the development of a hyperinflammatory state in infectious diseases.
Damir Mihić +8 more
doaj +1 more source
Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2 [PDF]
, 2005 In this study we analysed the outcome of the interaction between HPV-16 L2 and E2 on the transactivation and DNA replication functions of E2. When E2 was expressed on its own, it transactivated a number of E2-responsive promoters but co-expression of L2 ...
Morgan, I.M. +11 more
core +1 more source