Results 1 to 10 of about 73,522 (298)
Crystal structure of rat heme oxygenase-1 in complex with heme [PDF]
FEBS Letters, 2000 Heme oxygenase catalyzes the oxidative cleavage of protoheme to biliverdin, the first step of heme metabolism utilizing O2 and NADPH. We determined the crystal structures of rat heme oxygenase‐1 (HO‐1)–heme and selenomethionyl HO‐1–heme complexes. Heme is sandwiched between two helices with the δ‐meso edge of the heme being exposed to the surface ...
Masakazu Sugishima +2 more
exaly +4 more sources
Immunolocalization of heme oxygenase-1 in periodontal diseases
Indian Journal of Dental Research, 2014 Context: Chronic periodontitis is an inflammatory condition of supporting tissues initiated by organisms in dental plaque. The reactive oxygen species and free radicals mediate connective tissue destruction in periodontitis.
G Gayathri +3 more
doaj +4 more sources
Journal of Microbiology, Immunology and Infection, 2021 Increased heme levels, anemia, and desaturation occur during infection. We aimed to compare the levels of heme, heme oxygenase-1 (HO-1), ferritin, and bilirubin in coronavirus disease 2019 (COVID-19) patients at different saturation levels. Heme and HO-1
Wen-Lin Su +2 more
exaly +4 more sources
Heme oxygenase-1 and malaria pathogenesis [PDF]
Frontiers in ImmunologyMalaria is a life-threatening parasitic disease and remains a major cause of morbidity and mortality worldwide. The clinical course of malaria ranges from uncomplicated infection to severe disease, driven by extensive hemolysis, inflammation, and ...
Theophilus Wakai +4 more
doaj +2 more sources
Heme, Heme Oxygenase-1, Statins, and SARS-CoV-2
Antioxidants, 2023 Heme, a metalloporphyrin, or more specifically, a tetrapyrrole containing ferrous iron, is an ancient molecule [...]
David K. Stevenson +2 more
doaj +3 more sources
How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. [PDF]
PLoS ONE, 2015 Earlier observations indicate that free heme is selectively toxic to cells lacking heme oxygenase-1 (HO-1) but how this enzyme prevents heme toxicity remains unexplained.
Lilibeth Lanceta +3 more
doaj +2 more sources
Immune-Related Functions of Heme Oxygenase-1
Antioxidants, 2023 Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]
Elias A. Lianos, Maria G. Detsika
doaj +2 more sources
Heme oxygenase-1, oxidation, inflammation and atherosclerosis [PDF]
Frontiers in Pharmacology, 2012 Atherosclerosis is an inflammatory process of the vascular wall characterized by the infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low density lipoproteins and induction of oxidative stress play a major role in ...
Jesus A Araujo, Min eZhang, Fen eYin
doaj +3 more sources
HEME OXYGENASE-1 AND FATTY LIVER DISEASE. [PDF]
Euromediterranean Biomedical Journal, 2016 Fatty liver diseases are a spectrum of liver pathologies characterized by abnormal hepatocellular accumulations of lipids. This condition may occur in both adults and children, particularly those who are obese or have insulin resistance or following ...
Daniela Nicolosi
doaj +3 more sources
Heme oxygenase 1 overexpression increases iron fluxes in Caco-2 cells [PDF]
Biological Research, 2006 Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe.
MARÍA JOSE MENDIBURO +3 more
doaj +1 more source