Results 21 to 30 of about 29,728,056 (205)
Innate Immunity, 2019 Our previous study indicated an important protective role of transient receptor potential melastatin 2 (TRPM2) in controlling bacterial clearance in macrophages during polymicrobial sepsis by regulating heme oxygenase-1.
XiaoWei Qian, Hao Cheng, XinZhong Chen
doaj +1 more source
BMC Complementary and Alternative Medicine, 2011 Background Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary and alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of resveratrol and its interactions with ...
Hori Osamu +9 more
doaj +1 more source
Haematologica, 2015 Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during ...
Ceri Evans +6 more
doaj +1 more source
Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. [PDF]
PLoS ONE, 2011 In mammalian cells, heme can be degraded by heme-oxygenases (HO). Heme-oxygenase 1 (HO-1) is known to be the heme inducible isoform, whereas heme-oxygenase 2 (HO-2) is the constitutive enzyme.
Liliane R Alves +10 more
doaj +1 more source
Altered heme catabolism by heme oxygenase-1 caused by mutations in human NADPH cytochrome P450 reductase [PDF]
, 2010 Human heme oxygenase-1 (HO-1) carries out heme catabolism supported by electrons supplied from the NADPH through NADPH P450 reductase (POR, CPR). Previously we have shown that mutations in human POR cause a rare form of congenital adrenal hyperplasia. In
Primus E. Mullis +5 more
core +1 more source
Heme oxygenase-1 deletion affects stress erythropoiesis. [PDF]
PLoS ONE, 2011 BACKGROUND:Homeostatic erythropoiesis leads to the formation of mature red blood cells under non-stress conditions, and the production of new erythrocytes occurs as the need arises.
Yu-An Cao +5 more
doaj +1 more source
Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury
Antioxidants, 2021 Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of ...
Maria G. Detsika, Elias A. Lianos
doaj +1 more source
Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions
Brazilian Journal of Medical and Biological Research, 1999 Carbon monoxide (CO) is a pollutant commonly recognized for its toxicological attributes, including CNS and cardiovascular effects. But CO is also formed endogenously in mammalian tissues. Endogenously formed CO normally arises from heme degradation in a
R.A. Johnson, F. Kozma, E. Colombari
doaj +1 more source
HEME OXYGENASE-1 AND FATTY LIVER DISEASE. [PDF]
Euromediterranean Biomedical Journal, 2016 Fatty liver diseases are a spectrum of liver pathologies characterized by abnormal hepatocellular accumulations of lipids. This condition may occur in both adults and children, particularly those who are obese or have insulin resistance or following ...
Daniela Nicolosi
doaj +1 more source
Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors
Data in Brief, 2017 The data have been obtained from the Heme Oxygenase Database (HemeOxDB) and refined according to the 2D-QSAR requirements. These data provide information about a set of more than 380 Heme Oxygenase-1 (HO-1) inhibitors.
Emanuele Amata +9 more
doaj +1 more source