Results 1 to 10 of about 63,602 (67)

Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (The Ludwigshafen risk and cardiovascular health study) [PDF]

, 2009
Background Heme oxygenase-1 is an inducible cytoprotective enzyme which handles oxidative stress by generating anti-oxidant bilirubin and vasodilating carbon monoxide.
Hoffmann Michael M, Hoffmann, Michael Marcus, März Winfried, Boehm Bernhard O, Wellnitz Britta, Karl Winkler, Bernhard O Boehm, Bernhard R Winkelmann, März, Winfried, Winkelmann Bernhard R, Winkler Karl, Hoffmann, Michael M., Seelhorst Ursula, Ursula Seelhorst, Seelhorst, Ursula, Britta Wellnitz, Böhm, Bernhard O., Böhm, Bernhard Otto, Michael M Hoffmann, Lüblinghoff Nicola, Lüblinghoff, Nicola, Winkelmann, Bernhard Rudolf, Winfried März, Winkler, Karl, Nicola Lüblinghoff, Winkelmann, Bernhard R., Wellnitz, Britta   +26 more
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Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis [PDF]

, 2023
The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress.
Rachitha Singhabahu, Sujani M. Kodagoda Gamage, Gopalan, Vinod, Kodagoda Gamage, SM, Singhabahu, Rachitha, Singhabahu, R, Vinod Gopalan, Gopalan, V, Kodagoda Gamage, Sujani M; id_orcid   +8 more
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HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children. [PDF]

, 2012
Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression.
Madi Njie (177625), Walther, Brigitte, Cunnington, A., De Caul, A, Sebastian Weis, Ebonyi, A., Deininger Susanne, Aka Peter, Deininger, S., Peter Aka, Takem, Ebako N, Predazzi, Irene M, Conway David J., Predazzi, IM, Cunnington, Aubrey, Walther, Michael, Conway, DJ, Aubrey Cunnington, Njie, M., Predazzi, I. M., Weis Sebastian, Augustine Ebonyi (177659), Sarah Rowland-Jones, Walther Michael, Amambua-Ngwa, A., Sarah Rowland-Jones (74678), Scott M. Williams (177668), Robert Walton, Susanne Deininger (173844), Sirugo, G, Cunnington Aubrey, Njie, Madi, Williams Scott M., Sirugo, Giorgio, Weis, S, Augustine Ebonyi, Walton Robert, Aka, P, Aka, P., Rowland-Jones Sarah, Williams, Scott M, Williams, S. M., Ebonyi, A, Alfred Amambua-Ngwa (122336), Weis, Sebastian, De Caul, Adam, Williams, SM, Sebastian Weis (161447), Amambua-Ngwa Alfred, Takem Ebako N., Deininger, Susanne, Adam De Caul (177612), Giorgio Sirugo, Ebako N. Takem (177656), Amambua-Ngwa, A, Walton, Robert T., Ebonyi, Augustine, Alfred Amambua-Ngwa, Madi Njie, Michael Walther, Rowland-Jones, S., Giorgio Sirugo (62489), Aka, Peter, Walton, R, Njie, M, De Caul Adam, Njie Madi, Rowland-Jones, Sarah, Takem, EN, Predazzi Irene M., Takem, E. N., Robert Walton (177664), Amambua-Ngwa, Alfred, Conway, D. J., Adam De Caul, Walther, B., Weis, S., Deininger, S, Susanne Deininger, Aubrey Cunnington (177640), Conway, David J, Peter Aka (177618), Sirugo, G., Ebako N Takem, David J Conway, David J. Conway (34880), de Caul, A., Irene M. Predazzi (177634), Brigitte Walther (130764), Walther, M, Walther, M., Walther Brigitte, Walton, Robert, Cunnington, A, Scott M Williams, Irene M Predazzi, Sirugo Giorgio, Walther, B, Rowland-Jones, S, Brigitte Walther, Michael Walther (130767), Ebonyi Augustine   +101 more
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Immune-Related Functions of Heme Oxygenase-1

, 2023
Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...
Maria G. Detsika, Elias A. Lianos
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Nuclear Factor-κB-Independent Anti-Inflammatory Action of Salicylate in Human Endothelial Cells [PDF]

, 2006
In contrast to aspirin, salicylate, its active metabolite, possesses profound anti-inflammatory properties without blocking cyclooxygenase. Inhibition of the transcription factor nuclear factor-κB (NF-κB) has been discussed to play a role in the anti ...
Blumenthal, Signe B., Vollmar, Angelika M., Kiemer, Alexandra K., Zahler, Stefan, Fürst, Robert   +4 more
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Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children. [PDF]

, 2010
BACKGROUND: Cerebral malaria (CM) represents a severe outcome of the Plasmodium falciparum infection. Recent genetic studies have correlated human genes with severe malaria susceptibility, but there is little data on genetic variants that increase the ...
Sambo, Maria Rosário, Carla Benchimol, Marques, Maria Isabel, Nuno Sepúlveda, Carlos Penha-Gonçalves, Maria Rosário Sambo, Maria Isabel Marques, Stefan Mustafa, Sepúlveda, Nuno, Sepúlveda Nuno, Gonçalves Lígia, Trovoada, Maria Jesus, Mustafa Stefan, Rute Velosa, Marques Maria Isabel, Velosa, Rute, António Coutinho, Benchimol, Carla, Vatúsia Quinhentos, Sambo Maria Rosário, Quinhentos Vatúsia, Oswald Wagner, Taane G Clark, Benchimol Carla, Penha-Gonçalves Carlos, Penha-Gonçalves, Carlos, Gonçalves, Lígia, Mustafa, Stefan, Coutinho, António, Maria Jesus Trovoada, Coutinho António, Clark Taane G., Lígia Gonçalves, Trovoada Maria Jesus, Quinhentos, Vatúsia, Wagner, Oswald, Wagner Oswald, Taane G. Clark, Clark, Taane G, Velosa Rute, Clark, Taane G.   +40 more
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Creation of novel pharmacological tools in heme oxygenase research [PDF]

, 2012
Aims: While great strides have been made in the elucidation of the physiological and pharmacological roles of heme oxygenases (HO) in experimental animals and humans, there is still an enormous potential for further research discoveries and their ...
Vukomanovic, Dragic, Hum, Maaike, Rahman, Mona N., McLaughlin, Brian E., Dercho , Ryan, Brien, James F., Vlahakis, Jason Z., Jia, Zongchao, Kinobe, Robert T., Szarek, Walter A., Roman, Gheorghe, Nakatsu, Kanji   +11 more
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Heme oxygenase substrates acutely lower blood pressure in hypertensive rats

, 1996
Heme oxygenase catalyzes the metabolism of heme to biliverdine, free iron, and carbon monoxide. The current study was designed to determine if treatment with the heme oxygenase substrates heme-L-arginate or heme-L-lysinate, to stimulate formation of ...
M. Lavesa, M. J. Scholer, R. A. Johnson, K. DeSeyn, A. Nasjletti   +4 more
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Evidence for Heme Oxygenase Activity in a Heme Peroxidase

, 2016
The heme peroxidase and heme oxygenase enzymes share a common heme prosthetic group but catalyze fundamentally different reactions, the first being H2O2-dependent oxidation of substrate using an oxidized Compound I intermediate, and the second O2 ...
Clive L. Metcalfe (2163964), Andrea Gumiero (2163955), Jaswir Basran (1280517), Emma Lloyd Raven (1280520), Sandeep Handa (1280511), Zoi Pipirou (2369983), Graham Eaton (1280529), Sharad Mistry (2369980), Peter C. E. Moody (2163961), Sandip K. Badyal (2163952)   +9 more
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Regulation of haem oxygenase-1 nitrosative stress in cardiac cells. [PDF]

, 2005
The reactive nitrogen species (RNS) nitric oxide (NO), nitroxyl anion (NO") and nitrosonium cation (NO+), modulate a myriad of biological processes. The microsomal haem oxygenases (HO-1, HO-2 and HO-3) oxidatively catabolise haem to bilirubin, carbon ...
Naughton, P.
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