Results 31 to 40 of about 63,602 (67)

Heme oxygenase-1-derived carbon monoxide stimulates adenosine triphosphate generation in human hepatocyte

, 2005
Heme oxygenases cleave the pro-oxidant heme molecule into carbon monoxide, ferrous iron, and biliverdin, which is subsequently converted to bilirubin.
Schlitt, Hans J., Tsui, Tung-Yu, Fan, ST, Siu, Yeung-Tung, Siu, YT, Fan, Sheung-Tat, Schlitt, HJ, Tsui, TY   +7 more
core   +1 more source

Inductive transcription and protective role of fish heme oxygenase-1 under hypoxic stress

, 2008
Heme oxygenase-1 is the rate-limiting enzyme in the degradation of heme into biliverdin, carbon monoxide and free divalent iron. In this study, we cloned heme oxygenase isoform 1 (CaHO-1) from a hypoxia-tolerant teleost fish Carassius auratus.
Wang, Dan, Zhong, Xue-Ping, Gui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Qiao, Zhi-Xian, Gui, Jian-Fang   +4 more
core   +1 more source

Spectroscopic Studies Reveal That the Heme Regulatory Motifs of Heme Oxygenase‑2 Are Dynamically Disordered and Exhibit Redox- Dependent Interaction with Heme

, 2015
: Heme oxygenase (HO) catalyzes a key step ...
Brian M. Hoffman (1270242), Ritimukta Sarangi (1266243), Angela S. Fleischhacker, Erik R. P. Zuiderweg, Ireena Bagai, Stephen W. Ragsdale, Stephen W. Ragsdale (1264635), Ajay Sharma (48991), Erik R. P. Zuiderweg (1357830), Ireena Bagai (1357824), Brian M. Hoffman, Ritimukta Sarangi, Angela S. Fleischhacker (1357827), Ajay Sharma   +13 more
core   +1 more source

Proposed reaction pathway for the formation of biliverdin IXγ from heme by a heme oxygenase-like mechanism.

, 2014
Proposed reaction pathway for the formation of biliverdin IXγ from heme by a heme oxygenase-like mechanism.
Ana B. G. Veiga (589839), Ivo M. B. Francischetti (114544), Jorge A. Guimarães (589840), John F. Andersen (132069), José M. C. Ribeiro (123592), Xueqing Xu (50545)   +5 more
core   +1 more source

Expression of inducible heme oxygenase in human endometrium

, 2002
Heme oxygenase (HO) was initially described as the regulatory enzyme in the heme degradative pathways. It catalyzes the conversion of heme into carbon monoxide (CO), iron, and biliverdin, which acts as an antioxidant.
Casanas-Roux, Françoise, Van Langendonckt, Anne, Dolmans, Marie-Madeleine, Donnez, Jacques   +3 more
core   +1 more source

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

, 2017
Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)–NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron.
Fumio Kishi, Kishi, Fumio, Izumi Yanatori, Yanatori, Izumi, Richardson, Des R, Shinya Toyokuni, Des R. Richardson, Toyokuni, Shinya   +7 more
core   +1 more source

Guanosine has no effect on heme-oxygenase-2 protein expression in PC12 cells

, 2011
Copyright information:Taken from "Guanosine stimulates neurite outgrowth in PC12 cells via activation of heme oxygenase and cyclic GMP"Purinergic Signalling 2005;1(2):161-172.Published online Jan 2005PMCID:PMC2096532.
Shaun Hindley (82281), Shucui Jiang (82282), Christian Bau (82279), Renata Ciccarelli (82283), Michel P. Rathbone (82287), Francesco Caciagli (82284), Pamela J. Middlemiss (82280), Eva S. Werstiuk (82286), Patrizia DiIorio (82285)   +8 more
core   +1 more source

Highly Selective Novel Heme Oxygenase-1-Targeting Molecules Discovered by DNA-Encoded Library-Machine Learning Model beyond the DEL Chemical Space [PDF]

DNA-encoded library (DEL) technology has proven to be a powerful method for discovering novel inhibitors for diverse targets. Particularly when combined with machine learning (ML), the DEL-ML workflow expands the chemical space and enhances cost ...
Xinyun, Guo, Min, Wang, Yidan, Song, Wenji , Su, Kuang-Lung, Hsueh, Letian, Kuai, Shuai, Han, Yunyun, He, Huan, Liu, Weiren , Cui, Jason , Deng   +10 more
core   +2 more sources

Protein/Protein Interactions in the Mammalian Heme Degradation Pathway \u3ci\u3eHEME OXYGENASE-2, CYTOCHROME P450 REDUCTASE, AND BILIVERDIN REDUCTASE\u3c/i\u3e [PDF]

, 2014
Background: Heme oxygenase, cytochrome P450 reductase, and biliverdin reductase are the key enzymes in heme degradation. Results: Specific electrostatic and hydrophobic interactions form the binding interface between heme oxygenase and cytochrome P450 ...
Zuiderweg, Erik R. P., Bagai, Ireena, Becker, Donald F., Ragsdale, Stephen W., Spencer, Andrea L. M.   +4 more
core  

Model Studies for Heme Oxygenase-Catalyzed Porphyrin Meso Hydroxylation

, 2016
Nonenzymatic model studies based on a porphyrin analogue (2,4-diacetyldeuteroporphyrin) that avoid the steric effect complications of the heme oxygenase active site were carried out to determine the polarity of the ferric hydroperoxide attacking species.
Yaoqiu Zhu (1982086), Richard B. Silverman (685069)   +1 more
core   +1 more source