, 2017 Mammals incorporate a major proportion of absorbed iron as heme, which is catabolized by the heme oxygenase 1 (HO1)–NADPH-cytochrome P450 reductase (CPR) complex into biliverdin, carbon monoxide, and ferrous iron.
Fumio Kishi +7 more
core +1 more source
The heme oxygenase(s)-phytochrome system of Pseudomonas aeruginosa [PDF]
, 2004 For many pathogenic bacteria like Pseudomonas aeruginosa heme is an essential source of iron. After uptake, the heme molecule is degraded by heme oxygenases to yield iron, carbon monoxide, and biliverdin.
Wegele, Rosalina +4 more
core +1 more source
Inductive transcription and protective role of fish heme oxygenase-1 under hypoxic stress
, 2008 Heme oxygenase-1 is the rate-limiting enzyme in the degradation of heme into biliverdin, carbon monoxide and free divalent iron. In this study, we cloned heme oxygenase isoform 1 (CaHO-1) from a hypoxia-tolerant teleost fish Carassius auratus.
Wang, Dan +4 more
core +1 more source
Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
, 2008 Shigeru Maeda1, Ichiro Nakatsuka1, Yukiko Hayashi1, Hitoshi Higuchi1, Masahiko Shimada2, Takuya Miyawaki11Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan; 2Orofacial Pain Management, Department of Oral Restitution ...
Hitoshi Higuchi +5 more
core
Biochemical properties and bioactivities of carbon monoxide-releasing molecules (CO-RMs). [PDF]
, 2006 Carbon monoxide (CO), synonymous of the "silent killer", is rapidly emerging as an important and versatile mediator of physiological processes. The study of CO has been hampered by the lack of a means to simulate its release biologically.
Sawle, P.J., Sawle, Philip John
core
Down-regulation of heme oxygenase-1 by SVCV infection
, 2012 Heme oxygenase (HO-1) is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes.
Shi, Zhengli +6 more
core +1 more source
Immunolocalization of heme oxygenase-1 in periodontal diseases
, 2014 Context: Chronic periodontitis is an inflammatory condition of supporting tissues initiated by organisms in dental plaque. The reactive oxygen species and free radicals mediate connective tissue destruction in periodontitis.
Leena Dennis Joseph +3 more
core +1 more source
Maximum likelihood tree and schematic diagrams of heme oxygenase proteins.
, 2018 Maximum likelihood (ML) tree based on an alignment of 510 heme oxygenase amino acid sequences from 1,678 taxa. Red algal heme oxygenases had three isotypes of heme oxygenase; HMOX1, HMOX2, and pbsA.
Kyeong Mi Kim (5184491) +4 more
core +1 more source
Fumarate hydratase (FH); heme oxygenase decycling 1 (HMOX1; HO-1) [PDF]
Science-Business eXchange, 2011 openaire +1 more source
Highly Selective Novel Heme Oxygenase-1-Targeting Molecules Discovered by DNA-Encoded Library-Machine Learning Model beyond the DEL Chemical Space [PDF]
DNA-encoded library (DEL) technology has proven to be a powerful method for discovering novel inhibitors for diverse targets. Particularly when combined with machine learning (ML), the DEL-ML workflow expands the chemical space and enhances cost ...
Xinyun, Guo +10 more
core +2 more sources