Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress
, 2017 The phenomenon that heme oxygenase-1 (HO-1) protects cell from injury yet its enzymatic product, iron, may facilitate generation of free radical has been long puzzling. Here we establish a functional connection between ferritin heavy chain (FHC) and HO-1.
Cheng, Hui-Teng;Yen, Chung-Jen;Chang, Chen-Chih;Huang, Kuo-Tong;Chen, Kuo-Hsuan;Zhang, Rui-Yang;Lee, Ping-Yi;Miaw, Shi-Chuen;Huang, Jenq-Wen;Chiang, Chih-Kang;Wu, Kwan-Dun;Hung, Kuan-Yu +1 more
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The oxidative degradation of heme in the carbon monoxide/heme oxygenase (CO/HO) pathway.
, 2012 The oxidative degradation of heme in the carbon monoxide/heme oxygenase (CO/HO) pathway.
Mona N. Rahman (187137) +6 more
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Role of sphingosine-1-phosphate receptor 1 and downstream heme oxygenase-1 induction in alternative macrophage activation induced by apoptotic cells [PDF]
, 2010 Macrophages show a remarkable functional plasticity, which enables them to change their phenotype in response to environmental signals. They are key players during infection by initiating inflammation through the release of proinflammatory mediators ...
Weis, Nicole
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The effects of Bilirubin and Bilirubin-di-taurate on ischemia reperfusion injruy in a rat model of kidney transplantation [PDF]
, 2011 Background: Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the conversion of heme into biliverdin, carbon monoxide (CO) and free iron. Biliverdin is then subsequently reduced to bilirubin by the enzyme bilverdin reductase.
Thomas, Michael
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Chinese Journal of Contemporary Neurology and Neurosurgery, 2011 Objective To investigate the relationship among the expressions of heme⁃oxygenase⁃1 (HO ⁃ 1), glial fibrillary acidic protein (GFAP) and cyclinD1 in the perihematomal tissues in human intracerebral hemorrhage (ICH) and brain renovation following ICH ...
Wenzhao WANG +5 more
doaj
Heme catabolism and heme oxygenase in neurodegenerative disease
, 2004 Heme oxygenase, the rate-limiting step in heme catabolism, appears to play an important role in a number of neurodegenerative disorders, such as Alzheimer disease.
Takeda, Atsushi +7 more
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Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice. [PDF]
, 2020 Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complications. During the first trimester of human gestation, when palatogenesis takes place, intrauterine hematoma and hemorrhage are common phenomena, causing ...
Christiaan M. Suttorp +23 more
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Heme oxygenase, steering dioxygen activation toward heme hydroxylation
, 2005 The activation of dioxygen by heme oxygenase proceeds via formation of an obligatory ferric hydroperoxide intermediate (FeIII-OOH), as is the case in the activation of dioxygen by monooxygenase enzymes. This review summarizes current understanding of the
Zeng, Yuhong, Rivera, Mario
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The ferrous verdoheme-heme oxygenase complex is six-coordinate and low-spin
, 2005 A biosynthetic and enzymatic method was developed for the preparation of 13C-labeled verdoheme, which permits the 13C NMR spectroscopic characterization of this elusive intermediate in the heme oxidation path catalyzed by the enzyme heme oxygenase.
Damaso, Christopher O. +4 more
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, 2008 Heme oxygenase catalyzes the first and rate-controlling step in heme catabolism. One of the two forms of heme oxygenase (heme oxygenase-1) has been shown to be increased by heme, metals, and in some systems, by certain environmental stresses. However, it
Pepe, Joyce A. +4 more
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