Results 31 to 40 of about 94,120 (279)
Innate Immunity, 2019 Our previous study indicated an important protective role of transient receptor potential melastatin 2 (TRPM2) in controlling bacterial clearance in macrophages during polymicrobial sepsis by regulating heme oxygenase-1.
XiaoWei Qian, Hao Cheng, XinZhong Chen
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BMC Complementary and Alternative Medicine, 2011 Background Both resveratrol and vitamin C (ascorbic acid) are frequently used in complementary and alternative medicine. However, little is known about the underlying mechanisms for potential health benefits of resveratrol and its interactions with ...
Hori Osamu +9 more
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A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. [PDF]
, 2015 Aging is characterized by a progressive deterioration in physiological functions and metabolic processes. The loss of cells during aging in vital tissues and organs is related to several factors including oxidative stress and inflammation.
Borsani, Elisa +7 more
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Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. [PDF]
PLoS ONE, 2011 In mammalian cells, heme can be degraded by heme-oxygenases (HO). Heme-oxygenase 1 (HO-1) is known to be the heme inducible isoform, whereas heme-oxygenase 2 (HO-2) is the constitutive enzyme.
Liliane R Alves +10 more
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Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury
Antioxidants, 2021 Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of ...
Maria G. Detsika, Elias A. Lianos
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Effects of nanoparticles on murine macrophages [PDF]
, 2010 Metallic nanoparticles are more and more widely used in an increasing number of applications. Consequently, they are more and more present in the environment, and the risk that they may represent for human health must be evaluated.
A van Dorsselaer +11 more
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Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions
Brazilian Journal of Medical and Biological Research, 1999 Carbon monoxide (CO) is a pollutant commonly recognized for its toxicological attributes, including CNS and cardiovascular effects. But CO is also formed endogenously in mammalian tissues. Endogenously formed CO normally arises from heme degradation in a
R.A. Johnson, F. Kozma, E. Colombari
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Metalloporphyrins inactivate caspase-3 and -8 [PDF]
, 2005 Activation of caspases represents one of the earliest biochemical indicators for apoptotic cell death. Therefore, measurement of caspase activity is a widely used and generally accepted method to determine apoptosis in a wide range of in vivo and in ...
Blumenthal, Signe B. +8 more
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The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury. [PDF]
, 2010 The pregnane X receptor (PXR) is a nuclear receptor transcription factor regulating drug-metabolizing enzymes and transporters that facilitate xenobiotic and endobiotic detoxification.
Damjanov, Ivan +2 more
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Human AKI and Heme Oxygenase-1 [PDF]
Journal of the American Society of Nephrology, 2012 Findings derived from animal models of AKI gain clinical credence and appeal when translational studies corroborate their occurrence in human AKI. In the current issue of JASN , Zager et al.
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