Results 31 to 40 of about 29,728,056 (205)

Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection [PDF]

, 2013
Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of
Larsen, Rasmus, Appelberg, Rui, Sandro Silva Gomes, Rasmus Larsen, Miguel Parreira Soares, Soares, Miguel Parreira, Maria Salome Gomes, Silva-Gomes, Sandro, Gomes, Maria Salomé, Rui Appelberg, Sandro Silva-Gomes   +10 more
core   +1 more source

Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

Neural Regeneration Research
[INLINE:1] Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury models. Heme oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox homeostasis.
Zhihua Wang, Wu Zhou, Zhixiong Zhang, Lulu Zhang, Meihua Li   +4 more
doaj   +1 more source

Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter

Haematologica, 2013
Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity of therapeutic factor VIII in experimental hemophilia A.
Yohann Repessé, Ivan Peyron, Jordan D Dimitrov, Suryasarathi Dasgupta, Elika Farrokhi Moshai, Catherine Costa, Annie Borel-Derlon, Benoit Guillet, Roseline D’Oiron, Achille Aouba, Chantal Rothschild, Johannes Oldenburg, Anna Pavlova, Srinivas V Kaveri, Sébastien Lacroix-Desmazes   +14 more
doaj   +1 more source

The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease [PDF]

Journal of Integrative Neuroscience, 2020
We show that down-regulation of circular ribonucleic acid 0001588 with small interfering-circular ribonucleic acid 0001588 mimics promoted caspase-3 and caspase-9 activity levels, increased lactate dehydrogenase activity levels, and reduced cell growth ...
Rongyan Zhu, Xiuyan Qi, Cuiping Liu, Dongxin Wang, Li Li, Xiaofeng Liu, Yongge Hou, Xiaohui Su, Huiqian Lin
doaj   +1 more source

Heme oxygenase-1 & 2 and their potential contribution in heme induced colorectal carcinogenesis

, 2022
Background: Literature suggests Heme oxygenase (HO) system to be a double-edged sword which can promote both cytoprotection as well as carcinogenicity.
Cheng, Tracie, Lam, Alfred King-Yin, Gopalan, Vinod, Islam, Farhadul, Macfarlane, Lilian, Hewage, Dinu, Aktar, Sharmin, Nanayakkara, Sachith, Gamage, Sujani MK, Lu, Cu Tai, Dissabandara, Lakal   +10 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The effects of Bilirubin and Bilirubin-di-taurate on ischemia reperfusion injruy in a rat model of kidney transplantation [PDF]

, 2011
Background: Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in the conversion of heme into biliverdin, carbon monoxide (CO) and free iron. Biliverdin is then subsequently reduced to bilirubin by the enzyme bilverdin reductase.
Thomas, Michael
core   +1 more source

Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae

Angewandte Chemie, EarlyView.
The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray, Sohan Hazra, Ryan W. Mull, Erinn M. O'Neill, Bo Li   +4 more
wiley   +2 more sources

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

eJournal of Oral Maxillofacial Research, 2018
Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.
Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra   +6 more
doaj   +1 more source

Regulation of haem oxygenase-1 nitrosative stress in cardiac cells. [PDF]

, 2005
The reactive nitrogen species (RNS) nitric oxide (NO), nitroxyl anion (NO") and nitrosonium cation (NO+), modulate a myriad of biological processes. The microsomal haem oxygenases (HO-1, HO-2 and HO-3) oxidatively catabolise haem to bilirubin, carbon ...
Naughton, P.
core