Results 41 to 50 of about 73,522 (298)

Heme Oxygenase-1 in Tumors: Is It a False Friend? [PDF]

Antioxidants & Redox Signaling, 2007
Heme oxygenase-1 (HO-1) catalyzes the oxidation of heme to biologically active products: carbon monoxide (CO), biliverdin, and ferrous iron. It participates in maintaining cellular homeostasis and plays an important protective role in the tissues by reducing oxidative injury, attenuating the inflammatory response, inhibiting cell apoptosis, and ...
Józkowicz, Alicja, Waś, Halina, Dulak, Józef   +2 more
openaire   +3 more sources

Heme oxygenase-1 & 2 and their potential contribution in heme induced colorectal carcinogenesis

, 2022
Background: Literature suggests Heme oxygenase (HO) system to be a double-edged sword which can promote both cytoprotection as well as carcinogenicity.
Cheng, Tracie, Lam, Alfred King-Yin, Gopalan, Vinod, Islam, Farhadul, Macfarlane, Lilian, Hewage, Dinu, Aktar, Sharmin, Nanayakkara, Sachith, Gamage, Sujani MK, Lu, Cu Tai, Dissabandara, Lakal   +10 more
core   +1 more source

Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors

Data in Brief, 2017
The data have been obtained from the Heme Oxygenase Database (HemeOxDB) and refined according to the 2D-QSAR requirements. These data provide information about a set of more than 380 Heme Oxygenase-1 (HO-1) inhibitors.
Emanuele Amata, Agostino Marrazzo, Maria Dichiara, Maria N. Modica, Loredana Salerno, Orazio Prezzavento, Giovanni Nastasi, Antonio Rescifina, Giuseppe Romeo, Valeria Pittalà   +9 more
doaj   +1 more source

Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

Neural Regeneration Research
[INLINE:1] Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury models. Heme oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox homeostasis.
Zhihua Wang, Wu Zhou, Zhixiong Zhang, Lulu Zhang, Meihua Li   +4 more
doaj   +1 more source

Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter

Haematologica, 2013
Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity of therapeutic factor VIII in experimental hemophilia A.
Yohann Repessé, Ivan Peyron, Jordan D Dimitrov, Suryasarathi Dasgupta, Elika Farrokhi Moshai, Catherine Costa, Annie Borel-Derlon, Benoit Guillet, Roseline D’Oiron, Achille Aouba, Chantal Rothschild, Johannes Oldenburg, Anna Pavlova, Srinivas V Kaveri, Sébastien Lacroix-Desmazes   +14 more
doaj   +1 more source

The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease [PDF]

Journal of Integrative Neuroscience, 2020
We show that down-regulation of circular ribonucleic acid 0001588 with small interfering-circular ribonucleic acid 0001588 mimics promoted caspase-3 and caspase-9 activity levels, increased lactate dehydrogenase activity levels, and reduced cell growth ...
Rongyan Zhu, Xiuyan Qi, Cuiping Liu, Dongxin Wang, Li Li, Xiaofeng Liu, Yongge Hou, Xiaohui Su, Huiqian Lin
doaj   +1 more source

Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress

, 2017
The phenomenon that heme oxygenase-1 (HO-1) protects cell from injury yet its enzymatic product, iron, may facilitate generation of free radical has been long puzzling. Here we establish a functional connection between ferritin heavy chain (FHC) and HO-1.
Cheng, Hui-Teng;Yen, Chung-Jen;Chang, Chen-Chih;Huang, Kuo-Tong;Chen, Kuo-Hsuan;Zhang, Rui-Yang;Lee, Ping-Yi;Miaw, Shi-Chuen;Huang, Jenq-Wen;Chiang, Chih-Kang;Wu, Kwan-Dun;Hung, Kuan-Yu, 鄭暉騰;黃國棟;嚴崇仁;張慶忠;姜至剛;吳寬墩;洪冠予;黃政文;繆希椿   +1 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

eJournal of Oral Maxillofacial Research, 2018
Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.
Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra   +6 more
doaj   +1 more source

Heme Oxygenase-1 Deficiency [PDF]

Indian Pediatrics, 2021
Renji, Soumya, Shah, Nitin, Madkaikar, Manisha   +2 more
openaire   +3 more sources