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Heme Oxygenase-Like Metalloenzymes. [PDF]
Annu Rev BiochemHeme oxygenase (HO)-like metalloenzymes are an emerging protein superfamily diverse in reaction outcome and mechanism. Found primarily in bacterial biosynthetic pathways, members conserve a flexible protein scaffold shared with the heme catabolic enzyme, HO, and a set of metal-binding residues.
Pope SR +6 more
europepmc +4 more sources
Heme and immunity: The heme oxygenase dichotomy. [PDF]
J Inorg BiochemHeme, an iron containing organic ring, is required for a diverse range of biological processes across all forms of life. Although this nutrient is essential, its pro-inflammatory and cytotoxic properties can lead to cellular damage. Heme oxygenase 1 (HO-1) is an endoplasmic reticulum (ER)-anchored enzyme that degrades heme, releasing equimolar amounts ...
Perry M, Hamza I.
europepmc +3 more sources
Journal of Microbiology, Immunology and Infection, 2021 Increased heme levels, anemia, and desaturation occur during infection. We aimed to compare the levels of heme, heme oxygenase-1 (HO-1), ferritin, and bilirubin in coronavirus disease 2019 (COVID-19) patients at different saturation levels. Heme and HO-1
Wen-Lin Su +2 more
exaly +3 more sources
Evidence for Heme Oxygenase Activity in a Heme Peroxidase
Biochemistry, 2009 The heme peroxidase and heme oxygenase enzymes share a common heme prosthetic group but catalyze fundamentally different reactions, the first being H(2)O(2)-dependent oxidation of substrate using an oxidized Compound I intermediate, and the second O(2)-dependent degradation of heme.
Badyal, SK +9 more
openaire +5 more sources
Heme Catabolism and Heme Oxygenase in Neurodegenerative Disease
Antioxidants & Redox Signaling, 2004 Heme oxygenase, the rate-limiting step in heme catabolism, appears to play an important role in a number of neurodegenerative disorders, such as Alzheimer disease. Interestingly, the spatial distribution of heme oxygenase-1 expression in diseased brain is essentially identical to that of the pathological expression of tau, suggesting a key role for ...
Takeda, Atsushi +7 more
openaire +4 more sources
Immunolocalization of heme oxygenase-1 in periodontal diseases
Indian Journal of Dental Research, 2014 Context: Chronic periodontitis is an inflammatory condition of supporting tissues initiated by organisms in dental plaque. The reactive oxygen species and free radicals mediate connective tissue destruction in periodontitis.
G Gayathri +3 more
doaj +2 more sources
Immune-Related Functions of Heme Oxygenase-1
Antioxidants, 2023 Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]
Elias A. Lianos, Maria G. Detsika
doaj +2 more sources
Heme oxygenase 1 overexpression increases iron fluxes in Caco-2 cells [PDF]
Biological Research, 2006 Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe.
MARÍA JOSE MENDIBURO +3 more
doaj +1 more source
Editorial: The heme oxygenase system in immunity [PDF]
Frontiers in ImmunologyDiego L. Costa +2 more
doaj +2 more sources
Pathological significance of heme oxygenase-1 as a potential tumor promoter in heme-induced colorectal carcinogenesis [PDF]
, 2023 The significance of the heme-metabolizing enzyme heme oxygenase-1 (HMOX1) in the pathogenesis of colorectal cancer (CRC) has not been fully explored. HMOX1 cytoprotection is imperative to limit oxidative stress.
Rachitha Singhabahu +8 more
core +1 more source