Results 41 to 50 of about 64,285 (304)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Strontium Ranelate Elevates Expression of Heme Oxygenase-1 and Decreases Alveolar Bone Loss in Rats

eJournal of Oral Maxillofacial Research, 2018
Objectives: The purpose of this study was to determine the effects of strontium ranelate on ligature-induced periodontitis in rats and assess the putative involvement of heme oxygenase-1 (HO-1) pathway in these effects.
Ricardo Basto Souza, Francisco Isaac Fernandes Gomes, Karuza Maria Alves Pereira, Paula Goes Pinheiro Dutra, Rodrigo Maranguape Silva da Cunha, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra   +6 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease [PDF]

Journal of Integrative Neuroscience, 2020
We show that down-regulation of circular ribonucleic acid 0001588 with small interfering-circular ribonucleic acid 0001588 mimics promoted caspase-3 and caspase-9 activity levels, increased lactate dehydrogenase activity levels, and reduced cell growth ...
Rongyan Zhu, Xiuyan Qi, Cuiping Liu, Dongxin Wang, Li Li, Xiaofeng Liu, Yongge Hou, Xiaohui Su, Huiqian Lin
doaj   +1 more source

Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress

, 2017
The phenomenon that heme oxygenase-1 (HO-1) protects cell from injury yet its enzymatic product, iron, may facilitate generation of free radical has been long puzzling. Here we establish a functional connection between ferritin heavy chain (FHC) and HO-1.
Cheng, Hui-Teng;Yen, Chung-Jen;Chang, Chen-Chih;Huang, Kuo-Tong;Chen, Kuo-Hsuan;Zhang, Rui-Yang;Lee, Ping-Yi;Miaw, Shi-Chuen;Huang, Jenq-Wen;Chiang, Chih-Kang;Wu, Kwan-Dun;Hung, Kuan-Yu, 鄭暉騰;黃國棟;嚴崇仁;張慶忠;姜至剛;吳寬墩;洪冠予;黃政文;繆希椿   +1 more
core   +1 more source

Heme Oxygenase Protects against Placental Vascular Inflammation and Abortion by the Alarmin Heme in Mice. [PDF]

, 2020
Both infectious as non-infectious inflammation can cause placental dysfunction and pregnancy complications. During the first trimester of human gestation, when palatogenesis takes place, intrauterine hematoma and hemorrhage are common phenomena, causing ...
Christiaan M. Suttorp, Suttorp, Christiaan M, van Rheden, Rene E. M., Suttorp, Christiaan M., Kuijpers-Jagtman, Anne Marie; id_orcid, Helmich, M.P.A.C., van Dijk, Natasja W. M., René E. M. van Rheden, Helmich, Maria P. A. C., Wagener, F.A.D.T.G., Rheden, R.E.M. van, Dijk, N.W.M. van, Wagener, Frank A D T G, Anne Marie Kuijpers-Jagtman, Frank A. D. T. G. Wagener, Wagener, Frank A. D. T. G., Helmich, Maria P A C, Kuijpers-Jagtman, Anne Marie, Maria P. A. C. Helmich, van Rheden, René E M, van Dijk, Natasja W M, Suttorp, C.M., Kuijpers-Jagtman, A.M., Natasja W. M. van Dijk   +23 more
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Hemin as a protective agent in an in vitro model of hypoxia/reoxygenation-induced injury

SAGE Open Medicine
Objective: Ischemia-reperfusion injury exacerbates myocardial damage and affects the prognosis of patients with ST-elevation myocardial infarction. This study investigates the potential cytoprotective effects of hemin in an in vitro cardiomyocyte model ...
Zuoyan Wang, Wei Liu
doaj   +1 more source

Heme-Oxygenase and Kidney Transplantation: A Potential for Target Therapy?

Biomolecules, 2020
Kidney transplantation is a well-established therapy for patients with end-stage renal disease. While a significant improvement of short-term results has been achieved in the short-term, similar results were not reported in the long-term. Heme-oxygenase (
Daniela Corona, Burcin Ekser, Rossella Gioco, Massimo Caruso, Chiara Schipa, Pierfrancesco Veroux, Alessia Giaquinta, Antonio Granata, Massimiliano Veroux   +8 more
doaj   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source