Results 61 to 70 of about 64,285 (304)
How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. [PDF]
PLoS ONE, 2015 Earlier observations indicate that free heme is selectively toxic to cells lacking heme oxygenase-1 (HO-1) but how this enzyme prevents heme toxicity remains unexplained.
Lilibeth Lanceta +3 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.In this study, we primarily simulated pathological myocardial remodeling induced by transverse aortic constriction surgery and found significant cardiac hypertrophy and fibrosis, characterized by deteriorated cardiac function. Oxidative stress response is considered as a pivotal pathological process, which contributes to inflammation and apoptosis of ...
Yijia Wang +12 more
wiley +1 more source
Biomedical and Biotechnology Research Journal, 2019 Background: Human immunodeficiency virus (HIV) infection is an important infection seen worldwide. HIV-infected patients usually have impaired immune function and get infected with other concurrent infections.
Won Sriwijitalai, Viroj Wiwanitkit
doaj +1 more source
Naringin Decreases TNF-α and HMGB1 Release from LPS-Stimulated Macrophages and Improves Survival in a CLP-Induced Sepsis Mice. [PDF]
PLoS ONE, 2016 Naringin, a flavanone glycoside extracted from various plants, has a wide range of pharmacological effects. In the present study, we investigated naringin's mechanism of action and its inhibitory effect on lipopolysaccharide-induced tumor necrosis factor-
Minchan Gil +3 more
doaj +1 more source
Heme-heme oxygenase-2 reduces the atherosclerosis by preventing inflammation
Current Research in Pharmacology and Drug Discovery, 2023 Objective: Heme oxygenase (HO) has been shown to have important antioxidant and anti-inflammatory properties, resulting in a vascular antitherogenic effect. This study was undertaken to evaluate the role of HO-2 in atherosclerosis.
Zhenzhen Wang +9 more
doaj +1 more source
, 2011 Background. The protective role of heme oxygenase-1 (HO-1) against liver ischemia-reperfusion (I/R) injury in models of hypoxic and remote preconditioning has been proved.
LAI, I-RUE;CHANG, KING-JEN;CHEN, CHAU-FONG +1 more
core +1 more source
Animal Research and One Health, EarlyView.Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang +10 more
wiley +1 more source
Developmental Biology of Heme Oxygenase
Clinics in Perinatology, 1990 The regulation of heme oxygenase activity in the developing neonate is essential to the control of bilirubin production as well as intracellular heme and hemoprotein metabolism. The coordinated activity of the microsomal enzymes, heme oxygenase and NADPH-cytochrome c (P450) reductase, and the cytosolic enzyme biliverdin reductase is responsible for the
P A, Rodgers, D K, Stevenson
openaire +2 more sources
Creation of novel pharmacological tools in heme oxygenase research [PDF]
, 2012 Aims: While great strides have been made in the elucidation of the physiological and pharmacological roles of heme oxygenases (HO) in experimental animals and humans, there is still an enormous potential for further research discoveries and their ...
Vukomanovic, Dragic +11 more
core
, 2010 Human heme oxygenase-1 (HO-1) carries out heme catabolism supported by electrons supplied from the NADPH through NADPH P450 reductase (POR, CPR). Previously we have shown that mutations in human POR cause a rare form of congenital adrenal hyperplasia. In
Primus E. Mullis +5 more
core +1 more source