Results 81 to 90 of about 120,535 (297)
Combined fluorometric analysis of biliverdin and bilirubin by the recombinant protein HUG
MethodsXBiliverdin is a secondary metabolite of heme catabolism. It is formed by the reaction catalyzed by heme oxygenase, which converts the heme group contained in proteins such as hemoglobin, myoglobin, cytochromes, and catalase into biliverdin, iron (II) and
Federica Tramer +5 more
doaj +1 more source
Haematologica, 2011 Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano +10 more
doaj +1 more source
The Ferrous Verdoheme−Heme Oxygenase Complex is Six-Coordinate and Low-Spin
, 2016 A biosynthetic and enzymatic method was developed for the preparation of 13C-labeled verdoheme, which permits the 13C NMR spectroscopic characterization of this elusive intermediate in the heme oxidation path catalyzed by the enzyme heme oxygenase.
Christopher O. Damaso (2659240) +4 more
core +1 more source
Pharmacological and Clinical Significance of Heme Oxygenase-1
, 2021 This Special Issue collates and updates the current knowledge of the pharmacology and clinical applications concerning the enzyme heme oxygenase (HO) [...
Nader G. Abraham +3 more
core +1 more source
Biological Reviews, EarlyView.ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley +1 more source
Characterization and Expression Analysis of Heme Oxygenase Genes from
Bioinformatics and Biology Insights, 2019 Heme oxygenases (HOs) have a major role in phytochrome chromophore biosynthesis, and chromophores in turn have anti-oxidant properties. Plant heme oxygenases are divided into the HO1 sub-family comprising HO1, HO3, and HO4, and the HO2 sub-family, which ...
Takalani Mulaudzi-Masuku +5 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.First direct observation of a quasi‐reversible superoxo (FeIII─O2˙ˉ)/peroxo (FeIII─O22ˉ) redox couple in a heme model complex, featuring a biologically relevant low‐spin ferric end‐on peroxo species stabilized by second‐sphere hydrogen bonding. These findings highlight the key role of second‐sphere interactions in modulating O2 activation pathways ...
Adelais Trapali +6 more
wiley +1 more source
Barrier Immunity, EarlyView.Negative feedback resulting from continuous TGFβRI expression in FLVCR1‐deficient CD4 T cells. Unlike in normal CD4 T cells, TGF‐βRI is not degraded upon activation in FLVCR1‐deficient CD4 T cells. Sustained receptor expression results in increased TGF‐β, leading to dysregulated iron homeostasis, impaired cell proliferation, and enhanced cell death ...
Amber L. Siglin +3 more
wiley +1 more source
, 2008 Heme oxygenase, the rate controlling enzyme for heme catabolism, is inducible by a variety of treatments, some of which induce by a heme-dependent mechanism and others by a heme-independent mechanism.
Greene, Yvonne J. +4 more
core +1 more source
Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis
ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen +7 more
wiley +1 more source