Results 101 to 110 of about 115,890 (298)

Heme oxygenase-1 & 2 and their potential contribution in heme induced colorectal carcinogenesis

, 2022
Background: Literature suggests Heme oxygenase (HO) system to be a double-edged sword which can promote both cytoprotection as well as carcinogenicity.
Cheng, Tracie, Lam, Alfred King-Yin, Gopalan, Vinod, Islam, Farhadul, Macfarlane, Lilian, Hewage, Dinu, Aktar, Sharmin, Nanayakkara, Sachith, Gamage, Sujani MK, Lu, Cu Tai, Dissabandara, Lakal   +10 more
core   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

Heme oxygenase-1, heme oxygenase-2 and biliverdin reductase in peripheral ganglia from rat, expression and plasticity

, 1999
The expression of inducible and constitutive heme oxygenase and biliverdin reductase was studied in normal and cultured peripheral ganglia from adult rats, using immunocytochemistry and in situ hybridization.
E. Elmér, M. Kanje, S. Magnusson, Magnusson, S, Ekstrom, J, P. Alm, J. Ekström, L. Ny, Elmer, Eskil, Kanje, Martin, Alm, Per, Ny, L   +11 more
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Neuroprotective effect of normal and modified mesenchymal stem cell‐derived exosomes by mitigating Alzheimer's‐related oxidative and inflammatory damage via Nrf2/HO‐1 in SH‐SY5Y cells

Ibrain, EarlyView.
Exosome therapy shows promise in Alzheimer's disease. This study compared normal and modified exosomes from AD brain extract‐treated MSCs in STZ‐induced SH‐SY5Y cells. Exosomes improved neuronal viability, reduced oxidative stress and inflammation, and activated Nrf2/HO‐1 signaling.
Rishika Dhapola, Prajjwal Sharma, Sneha Kumari, Balachandar Vellingiri, Dibbanti HariKrishnaReddy   +4 more
wiley   +1 more source

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position −7007 of the FPN1 promoter

Haematologica, 2010
Background Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported ...
Samuele Marro, Deborah Chiabrando, Erika Messana, Jens Stolte, Emilia Turco, Emanuela Tolosano, Martina U. Muckenthaler   +6 more
doaj   +1 more source

Evidence for Heme Oxygenase Activity in a Heme Peroxidase

, 2016
The heme peroxidase and heme oxygenase enzymes share a common heme prosthetic group but catalyze fundamentally different reactions, the first being H2O2-dependent oxidation of substrate using an oxidized Compound I intermediate, and the second O2 ...
Clive L. Metcalfe (2163964), Andrea Gumiero (2163955), Jaswir Basran (1280517), Emma Lloyd Raven (1280520), Sandeep Handa (1280511), Zoi Pipirou (2369983), Graham Eaton (1280529), Sharad Mistry (2369980), Peter C. E. Moody (2163961), Sandip K. Badyal (2163952)   +9 more
core   +1 more source

Clinical Relevance of BACH1 Expression in Non–Small Cell Lung Cancer

International Journal of Cancer, EarlyView.
ABSTRACT BTB and CNC homolog 1 (BACH1) is a redox‐sensitive transcription factor implicated in tumor progression, metabolic reprogramming, and therapy resistance in several cancers. However, its prognostic significance and role in therapy resistance in non–small cell lung cancer (NSCLC) remain unclear.
Jing Liu, Marc A. Schneider, Julia Held, Sabine Wrenger, Wenzhang Si, Michael Allgaeuer, Florian Eichhorn, Sabina Janciauskiene   +7 more
wiley   +1 more source

Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells

Interdisciplinary Medicine, EarlyView.
Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen, Jiayi Wang, Jimin Yu, Yiran Zhou, Lihai Liu, Jing Liu, Liang Wang   +6 more
wiley   +1 more source

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez, Sefa Küçükler, Selim Çomaklı, Hasan Şimşek, Özge Kandemir, Fatih Mehmet Kandemir, Şaban Maraşlı   +6 more
wiley   +1 more source