Results 121 to 130 of about 115,890 (298)
JCI Insight, 2020 Diabetes is a risk factor for myocardial infarction, and outcomes after myocardial infarction are worse among diabetics compared with nondiabetics. Diabetes is associated with impaired Heme clearance.
Rajesh Gupta +11 more
doaj +1 more source
Heme Oxygenase-1 Deficiency [PDF]
Indian Pediatrics, 2021 Renji, Soumya +2 more
openaire +3 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen +9 more
wiley +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
The clinical relevance of heme detoxification by the macrophage heme oxygenase system
Frontiers in ImmunologyHeme degradation by the heme oxygenase (HMOX) family of enzymes is critical for maintaining homeostasis and limiting heme-induced tissue damage. Macrophages express HMOX1 and 2 and are critical sites of heme degradation in healthy and diseased states ...
Scott Yeudall +4 more
doaj +1 more source
Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
, 2008 Shigeru Maeda1, Ichiro Nakatsuka1, Yukiko Hayashi1, Hitoshi Higuchi1, Masahiko Shimada2, Takuya Miyawaki11Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan; 2Orofacial Pain Management, Department of Oral Restitution ...
Hitoshi Higuchi +5 more
core
Biochemical properties and bioactivities of carbon monoxide-releasing molecules (CO-RMs). [PDF]
, 2006 Carbon monoxide (CO), synonymous of the "silent killer", is rapidly emerging as an important and versatile mediator of physiological processes. The study of CO has been hampered by the lack of a means to simulate its release biologically.
Sawle, P.J., Sawle, Philip John
core
Down-regulation of heme oxygenase-1 by SVCV infection
, 2012 Heme oxygenase (HO-1) is a cytoprotective enzyme that plays a critical role in defending the body against oxidant-induced injury during inflammatory processes.
Shi, Zhengli +6 more
core +1 more source
Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges
Neuroprotection, EarlyView.Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi +5 more
wiley +1 more source
Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling
Phytotherapy Research, EarlyView.Proposed mechanism by which Luteolin (LU) promotes diabetic foot ulcer healing. LU attenuates hyperglycemia‐induced oxidative stress and lipid peroxidation, improves endothelial cell viability, and suppresses ferroptosis through Nrf2‐dependent antioxidant signaling, thereby accelerating angiogenesis and wound repair. ABSTRACT Diabetic foot ulcers (DFUs)
Muhammed Yusuf +2 more
wiley +1 more source