Results 131 to 140 of about 120,535 (297)
Phytotherapy Research, EarlyView.This work proposes a mechanism in which ganoderic acid A (GAA), the active monomer of ganoderic acids (GA) from Ganoderma lucidum, binds to the glucocorticoid receptor (GR) to form a GR‐GAA complex, thereby inhibiting DEX‐induced GR activation. This inhibition suppresses oxidative stress (ROS, MDA and 4‐HNE) by upregulating antioxidant proteins (Nrf2 ...
Kecheng Tang +10 more
wiley +1 more source
Protein/Protein Interactions in the Mammalian Heme Degradation Pathway \u3ci\u3eHEME OXYGENASE-2, CYTOCHROME P450 REDUCTASE, AND BILIVERDIN REDUCTASE\u3c/i\u3e [PDF]
, 2014 Background: Heme oxygenase, cytochrome P450 reductase, and biliverdin reductase are the key enzymes in heme degradation. Results: Specific electrostatic and hydrophobic interactions form the binding interface between heme oxygenase and cytochrome P450 ...
Zuiderweg, Erik R. P. +4 more
core
Stimuli‐responsive nanostructured hydrogen sulfide donors for enhanced cancer treatments
Smart Molecules, EarlyView.Three typical kinds of stimuli‐responsive nanostructured hydrogen sulfide (H2S) donors are reviewed. The nanostructures ensure precise delivery of H2S to the lesion site and regulate the release behavior. The H2S‐based gas therapy has been used to synergize with other cancer treatment modalities, achieving enhanced efficacy while reducing side effects.
Yuxuan Lyu +7 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Malathion (MAL) is a widely used organophosphate pesticide associated with hepatotoxicity through oxidative stress and apoptosis. Morin, a naturally occurring flavonoid, exhibits potent antioxidant and anti‐inflammatory properties. This study investigated oxidative stress, inflammatory, and apoptotic alterations induced by acute and subacute ...
Seval Yılmaz +3 more
wiley +1 more source
Model Studies for Heme Oxygenase-Catalyzed Porphyrin Meso Hydroxylation
, 2016 Nonenzymatic model studies based on a porphyrin analogue (2,4-diacetyldeuteroporphyrin) that avoid the steric effect complications of the heme oxygenase active site were carried out to determine the polarity of the ferric hydroperoxide attacking species.
Yaoqiu Zhu (1982086) +1 more
core +1 more source
British Journal of Pharmacology, EarlyView.Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo +4 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Anthracyclines such as doxorubicin (DOXO) remain a cornerstone of cancer therapy but are associated with a high risk of cardiotoxicity and subsequent heart failure (HF). Impairment of NO/soluble guanylyl cyclase (sGC)/cGMP pathway has been reported in anthracycline‐induced cardiomyopathy.
Olga Gawrys +14 more
wiley +1 more source
Genetics and Molecular Biology, 2013 Blue egg coloring is attributed to biliverdin derived from the oxidative degradation of heme through catalysis by heme oxygenase (HO). The pigment is secreted into the eggshell by the shell gland.
ZhePeng Wang, RuiFang Liu, AnRu Wang
doaj
Redox mechanisms of the beneficial effects of heme oxygenase in hypertension
, 2014 Heme oxygenases, namely heme oxygenase-1 and heme oxygenase-2, have important biological functions in vascular homeostasis. Heme oxygenase and its catabolic products, including bilirubin and carbon monoxide, have been implicated in blood pressure ...
Dusting, GJ (15629489) +3 more
core
, 2008 Heme oxygenase-1 is an inducible enzyme that catalyzes heme degradation and has been proposed to play a role in protecting cells against oxidative stress-related injury.
Davis, Roger J. +3 more
core +1 more source