Results 151 to 160 of about 64,501 (277)

The Ferrous Verdoheme−Heme Oxygenase Complex is Six-Coordinate and Low-Spin

, 2016
A biosynthetic and enzymatic method was developed for the preparation of 13C-labeled verdoheme, which permits the 13C NMR spectroscopic characterization of this elusive intermediate in the heme oxidation path catalyzed by the enzyme heme oxygenase.
Christopher O. Damaso (2659240), Mario Rivera (1314483), Richard A. Bunce (630478), Mikhail V. Barybin (1483429), Angela Wilks (1923148)   +4 more
core   +1 more source

A rare case of heme oxygenase deficiency: A case report and literature review

Clinical Case Reports
Key Clinical Message Heme oxygenase deficiency, a rare condition disrupting heme metabolism, has only nine reported cases. We present a 3‐year‐old boy with dysmorphic facies, asplenia, and normal bilirubin levels despite ongoing hemolysis.
Sai Santhosha Mrudula Alla, Pahel Agarwal, Dhruv J. Shah, Waseem Abrar Shajahan, Rakshna Ramsundar, Deekshitha Alla, Madhavi Ravulapalli, Satya Bora, Sanjay Pillai, Ruth G. Bayeh, Uday Kumar Repalle, Fnu Suhani   +11 more
doaj   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Post-Infarction Rescue of Myocardial Function Using Hemin

Acute myocardial infarction is a major contributor to heart failure but has yet to be fully addressed through current therapeutic interventions. In experimental models of myocardial infarction, pre-emptive heme oxygenase-1 induction directly reduces ...
Eadie, Ashley
core  

Highly Selective Novel Heme Oxygenase-1-Targeting Molecules Discovered by DNA-Encoded Library-Machine Learning Model beyond the DEL Chemical Space

DNA-encoded library (DEL) technology has proven to be a powerful method for discovering novel inhibitors for diverse targets. Particularly when combined with machine learning (ML), the DEL-ML workflow expands the chemical space and enhances cost ...
Xinyun, Guo, Min, Wang, Yidan, Song, Wenji , Su, Kuang-Lung, Hsueh, Letian, Kuai, Shuai, Han, Yunyun, He, Huan, Liu, Weiren , Cui, Jason , Deng   +10 more
core   +1 more source

Comparison of HMOX1 expression and enzyme activity in blue-shelled chickens and brown-shelled chickens

Genetics and Molecular Biology, 2013
Blue egg coloring is attributed to biliverdin derived from the oxidative degradation of heme through catalysis by heme oxygenase (HO). The pigment is secreted into the eggshell by the shell gland.
ZhePeng Wang, RuiFang Liu, AnRu Wang
doaj  

Interindividual variability in static apnoea performance is partly explained by genetic factors

Experimental Physiology, EarlyView.
Abstract A large interindividual variability exists in maximal apnoea duration and the physiological adjustments that occur during apnoea. Although a few genes have been found to be associated with some of the cardiovascular responses during apnoea, the extent to which genetic and environmental factors contribute to individual differences in apnoea ...
Anastasios Makris, Alexandros Sotiridis, Nickos Geladas, Kalliopi Gkouskou, Vassilis Klissouras, Maria D. Koskolou   +5 more
wiley   +1 more source

(Poly)phenols: Mechanisms of action and efficacy of contemporary supplements for exercise recovery and performance

Experimental Physiology, EarlyView.
Abstract (Poly)phenols are a diverse group of bioactive chemical compounds present in a wide range of plant‐ and animal‐based foods. Several thousands of (poly)phenols exist; many have potent biological effects, most notably antioxidant, anti‐inflammatory and vasodilatory.
Glyn Howatson, Tom Clifford
wiley   +1 more source

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source