Results 71 to 80 of about 120,535 (297)

Naringin Decreases TNF-α and HMGB1 Release from LPS-Stimulated Macrophages and Improves Survival in a CLP-Induced Sepsis Mice. [PDF]

PLoS ONE, 2016
Naringin, a flavanone glycoside extracted from various plants, has a wide range of pharmacological effects. In the present study, we investigated naringin's mechanism of action and its inhibitory effect on lipopolysaccharide-induced tumor necrosis factor-
Minchan Gil, Yun Kyu Kim, Sang Bum Hong, Kyung Jin Lee   +3 more
doaj   +1 more source

Evidence for Heme Oxygenase Activity in a Heme Peroxidase

, 2016
The heme peroxidase and heme oxygenase enzymes share a common heme prosthetic group but catalyze fundamentally different reactions, the first being H2O2-dependent oxidation of substrate using an oxidized Compound I intermediate, and the second O2 ...
Clive L. Metcalfe (2163964), Andrea Gumiero (2163955), Jaswir Basran (1280517), Emma Lloyd Raven (1280520), Sandeep Handa (1280511), Zoi Pipirou (2369983), Graham Eaton (1280529), Sharad Mistry (2369980), Peter C. E. Moody (2163961), Sandip K. Badyal (2163952)   +9 more
core   +1 more source

HEME OXYGENASE: ENZYME WITH FUNCTIONAL DIVERSITY [PDF]

Journal of Stress Physiology & Biochemistry, 2011
In recent years role of Heme oxygenase (HO) has been considered in nearly all living system including plants, animals and other organisms. The common role of heme oxygenase is the degradation of heme, although there is a diversity of additional role of ...
Shekhawat G. S., Dixit S., Verma K., Nasybullina E.I., Kosmachevskaya O.V., Topunov A.F.   +5 more
doaj  

Developmental Biology of Heme Oxygenase

Clinics in Perinatology, 1990
The regulation of heme oxygenase activity in the developing neonate is essential to the control of bilirubin production as well as intracellular heme and hemoprotein metabolism. The coordinated activity of the microsomal enzymes, heme oxygenase and NADPH-cytochrome c (P450) reductase, and the cytosolic enzyme biliverdin reductase is responsible for the
P A, Rodgers, D K, Stevenson
openaire   +2 more sources

Control of intracellular heme levels: Heme transporters and heme oxygenases

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
Heme serves as a co-factor in proteins involved in fundamental biological processes including oxidative metabolism, oxygen storage and transport, signal transduction and drug metabolism. In addition, heme is important for systemic iron homeostasis in mammals.
Khan, Anwar A., Quigley, John G.
openaire   +2 more sources

The ferrous verdoheme-heme oxygenase complex is six-coordinate and low-spin

, 2005
A biosynthetic and enzymatic method was developed for the preparation of 13C-labeled verdoheme, which permits the 13C NMR spectroscopic characterization of this elusive intermediate in the heme oxidation path catalyzed by the enzyme heme oxygenase.
Damaso, Christopher O., Wilks, Angela, Bunce, Richard A., Rivera, Mario, Barybin, Mikhail V.   +4 more
core   +1 more source

Extraintestinal Reprogramming of Colon‐Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut–Joint Axis

Arthritis &Rheumatology, EarlyView.
Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson, Connor Eck, Sucai Liu, Anna Helena Jonsson, Kristine A. Kuhn   +4 more
wiley   +1 more source

Curcumin and Heme Oxygenase: Neuroprotection and Beyond [PDF]

International Journal of Molecular Sciences, 2019
Curcumin is a natural polyphenol component of Curcuma longa Linn, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of curcumin, due to its activity in multiple antioxidant and anti ...
Emanuela Mhillaj, Andrea Tarozzi, Letizia Pruccoli, Vincenzo Cuomo, Luigia Trabace, Cesare Mancuso   +5 more
openaire   +3 more sources

Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response

, 2008
Heme oxygenase catalyzes the first and rate-controlling step in heme catabolism. One of the two forms of heme oxygenase (heme oxygenase-1) has been shown to be increased by heme, metals, and in some systems, by certain environmental stresses. However, it
Pepe, Joyce A., Lambrecht, Richard W., Cable, Edward Earl, Bonkovsky, Herbert L., Gildemeister, Otto S.   +4 more
core   +1 more source

An all‐in‐one fucosylated gold nanocluster probe enables NIR‐II imaging and multi‐mechanistic therapy of acute kidney injury

BMEMat, EarlyView.
This study developed a fucoside‐targeted gold nanocluster probe that enables early NIR‐II imaging and multi‐mechanistic therapy for acute kidney injury, effectively mitigating oxidative stress, modulating inflammatory responses, and inhibiting ferroptosis to improve renal outcomes. Abstract Acute kidney injury (AKI) remains a life‐threatening condition
Ping Zhang, Boning Tan, Suqing Feng, Beibei Gu, Ting Feng, Haiguang Zhu, Jianping Xie, Xun Yuan   +7 more
wiley   +1 more source