Results 51 to 60 of about 64,285 (304)
AgriFood: Journal of Agricultural Products for Food, EarlyView.The preparation for Tunisian pomegranate anthocyanin extract. The molecular mechanisms underlying the antioxidant effects of these compounds were investigated using network pharmacology and molecular docking. Antioxidant activity was evaluated through DPPH, ABTS, and FRAP assays, whereas the effects on oxidative stress and inflammation were examined in
Jing Zhang +6 more
wiley +1 more source
Porcine kidney xenotransplantation: From primate models to clinical reality
Animal Models and Experimental Medicine, EarlyView.In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo +3 more
wiley +1 more source
Neural Regeneration ResearchInterfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury. Fibroblast growth factor 21 can inhibit ferroptosis and promote neurofunctional recovery, while heme oxygenase-1 is a regulator of iron and reactive ...
Qi Gu +10 more
doaj +1 more source
Systemic hemin therapy attenuates blood–brain barrier disruption after intracerebral hemorrhage
Neurobiology of Disease, 2014 Injury to the blood–brain barrier (BBB) is a key feature of intracerebral hemorrhage (ICH) and may contribute to perihematomal cell injury. Pretreatment with the heme oxygenase (HO)-1 inducer hemin improves barrier function and neurological outcome in ...
Xiangping Lu +2 more
doaj +1 more source
Cytoprotective role of heme oxygenase-1 upregulation in progressive renal disease [PDF]
Einstein (São Paulo), 2009 Objective: This study evaluated the ability of heme oxygenase-1 to prevent or reverse renal fibrosis. Methods: Sprague-dawley male rats were submitted to unilateral ureteral obstruction and divided into groups: non-treated and hemin.
Matheus Corrêa Costa +9 more
doaj
Malaria and susceptibility to other infections [PDF]
Malaria is widely perceived as immunosuppressive. Despite extensive phenomenological description, the underlying mechanisms remain poorly described. The aim of this thesis was to identify possible mechanisms by which malaria modifies host defence, and
Cunnington, Aubrey Justin
core +1 more source
, 2023 Iron is an essential nutrient for many pathogenic bacteria, and the most abundant source of the metal in the host is heme. Heme is often degraded by a heme oxygenase, and the first such enzyme (HO-1) was discovered in mammals.
Lyles, Kristin V
core +1 more source
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source
Iranian Journal of Allergy, Asthma and Immunology, 2013 Up-regulation of CD4+CD25+CD127low/- regulatory T cells (Tregs) is a new target in the treatment of asthma. Human bone marrow mesenchymal stem cells can up-regulate CD4+CD25+CD127low/- regulatory T cells in vitro, meanwhile, heme oxygenase-1 (HO-1 ...
Jian-guo Li +6 more
doaj
Frontiers in Neurology, 2018 Intracerebral hemorrhage (ICH) is a fatal acute cerebrovascular disease, with a high morbidity and mortality. Following ICH, erythrocytes release heme and several of its metabolites, thereby contributing to brain edema and secondary brain damage.
Qian-Qian Li +4 more
doaj +1 more source