Results 31 to 40 of about 115,890 (298)
Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury
Antioxidants, 2021 Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of ...
Maria G. Detsika, Elias A. Lianos
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Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions
Brazilian Journal of Medical and Biological Research, 1999 Carbon monoxide (CO) is a pollutant commonly recognized for its toxicological attributes, including CNS and cardiovascular effects. But CO is also formed endogenously in mammalian tissues. Endogenously formed CO normally arises from heme degradation in a
R.A. Johnson, F. Kozma, E. Colombari
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Heme-oxygenases during erythropoiesis in K562 and human bone marrow cells. [PDF]
PLoS ONE, 2011 In mammalian cells, heme can be degraded by heme-oxygenases (HO). Heme-oxygenase 1 (HO-1) is known to be the heme inducible isoform, whereas heme-oxygenase 2 (HO-2) is the constitutive enzyme.
Liliane R Alves +10 more
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Nuclear Factor-κB-Independent Anti-Inflammatory Action of Salicylate in Human Endothelial Cells [PDF]
, 2006 In contrast to aspirin, salicylate, its active metabolite, possesses profound anti-inflammatory properties without blocking cyclooxygenase. Inhibition of the transcription factor nuclear factor-κB (NF-κB) has been discussed to play a role in the anti ...
Blumenthal, Signe B. +4 more
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Haematologica, 2015 Heme oxygenase-1 is critical for iron recycling during red blood cell turnover, whereas its impact on steady-state erythropoiesis and red blood cell lifespan is not known. We show here that in 8- to 14-week old mice, heme oxygenase-1 deficiency adversely
Stuart T. Fraser +13 more
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Innate Immunity, 2019 Our previous study indicated an important protective role of transient receptor potential melastatin 2 (TRPM2) in controlling bacterial clearance in macrophages during polymicrobial sepsis by regulating heme oxygenase-1.
XiaoWei Qian, Hao Cheng, XinZhong Chen
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Activation of locus coeruleus heme oxygenase-carbon monoxide pathway promoted an anxiolytic-like effect in rats [PDF]
Brazilian Journal of Medical and Biological Research, 2016 The heme oxygenase-carbon monoxide pathway has been shown to play an important role in many physiological processes and is capable of altering nociception modulation in the nervous system by stimulating soluble guanylate cyclase (sGC).
P.G. Carvalho-Costa +2 more
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Heme Oxygenase1 Level in Normotensive Pregnancy and Preeclampsia with Severe Features
Indonesian Journal of Obstetrics and Gynecology, 2016 Objective: To understand the relationship of heme oxygenase-1 (HO-1) level between normotensive pregnancy and preeclampsia with severe features. Method: The cross sectional study was conducted in the Department of Obstetrics and Gynecology, Faculty
Christian Homenta +2 more
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Heme oxygenase in pregnancy and preeclampsia [PDF]
Current Opinion in Nephrology and Hypertension, 2013 Emerging evidence supports an important role for the heme oxygenase system in the maintenance of a healthy pregnancy. This review attempts to collect these wide-ranging data and summarize the recent progress in the field.New studies looking at heme oxygenase depletion in a variety of animal models have demonstrated that the heme oxygenase system is an ...
Eric M, George, Joey P, Granger
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Haematologica, 2015 Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during ...
Ceri Evans +6 more
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