Results 31 to 40 of about 64,285 (304)

Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism.

PLoS ONE, 2017
Heme oxygenase from Leptospira interrogans is an important virulence factor. During catalysis, redox equivalents are provided to this enzyme by the plastidic-type ferredoxin-NADP+ reductase also found in L. interrogans.
Anabel Soldano, Sebastián Klinke, Lisandro H Otero, Mario Rivera, Daniela L Catalano-Dupuy, Eduardo A Ceccarelli   +5 more
doaj   +1 more source

Bacillus subtilis HmoB is a heme oxygenase with a novel structure [PDF]

BMB Reports, 2012
Iron availability is limited in the environment and mostbacteria have developed a system to acquire iron from hosthemoproteins. Heme oxygenase plays an important role bydegrading heme group and releasing the essential nutrientiron.
Seonghun Park, Sarah Choi, Jungwoo Choe
doaj   +1 more source

Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (The Ludwigshafen risk and cardiovascular health study)

, 2009
Background Heme oxygenase-1 is an inducible cytoprotective enzyme which handles oxidative stress by generating anti-oxidant bilirubin and vasodilating carbon monoxide.
Hoffmann Michael M, Hoffmann, Michael Marcus, März Winfried, Boehm Bernhard O, Wellnitz Britta, Karl Winkler, Bernhard O Boehm, Bernhard R Winkelmann, März, Winfried, Winkelmann Bernhard R, Winkler Karl, Hoffmann, Michael M., Seelhorst Ursula, Ursula Seelhorst, Seelhorst, Ursula, Britta Wellnitz, Böhm, Bernhard O., Böhm, Bernhard Otto, Michael M Hoffmann, Lüblinghoff Nicola, Lüblinghoff, Nicola, Winkelmann, Bernhard Rudolf, Winfried März, Winkler, Karl, Nicola Lüblinghoff, Winkelmann, Bernhard R., Wellnitz, Britta   +26 more
core   +1 more source

Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter

Haematologica, 2013
Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity of therapeutic factor VIII in experimental hemophilia A.
Yohann Repessé, Ivan Peyron, Jordan D Dimitrov, Suryasarathi Dasgupta, Elika Farrokhi Moshai, Catherine Costa, Annie Borel-Derlon, Benoit Guillet, Roseline D’Oiron, Achille Aouba, Chantal Rothschild, Johannes Oldenburg, Anna Pavlova, Srinivas V Kaveri, Sébastien Lacroix-Desmazes   +14 more
doaj   +1 more source

Heme oxygenase-1 in osteosarcoma

Journal of Cancer Research and Therapeutics, 2020
The present study was planned to analyze serum heme oxygenase-1 levels in osteosarcoma patients.Twenty five histopathologically confirmed cases of osteosarcoma localized without metastasis of all the ages attending the Orthopedic Clinics were included in the study group and twenty five patients having musculoskeletal pain (age and sex matched) served ...
Simmi, Kharb, M, Halder, Z S, Kundu
openaire   +2 more sources

Comprehensive data on a 2D-QSAR model for Heme Oxygenase isoform 1 inhibitors

Data in Brief, 2017
The data have been obtained from the Heme Oxygenase Database (HemeOxDB) and refined according to the 2D-QSAR requirements. These data provide information about a set of more than 380 Heme Oxygenase-1 (HO-1) inhibitors.
Emanuele Amata, Agostino Marrazzo, Maria Dichiara, Maria N. Modica, Loredana Salerno, Orazio Prezzavento, Giovanni Nastasi, Antonio Rescifina, Giuseppe Romeo, Valeria Pittalà   +9 more
doaj   +1 more source

Heme, Heme Oxygenase-1, Statins, and SARS-CoV-2

Antioxidants, 2023
Heme, a metalloporphyrin, or more specifically, a tetrapyrrole containing ferrous iron, is an ancient molecule [...]
David K. Stevenson, Hendrik J. Vreman, Ronald J. Wong   +2 more
doaj   +1 more source

Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection [PDF]

, 2013
Heme oxygenases (HO) catalyze the rate-limiting step of heme degradation. The cytoprotective action of the inducible HO-1 isoform, encoded by the Hmox1 gene, is required for host protection against systemic infections. Here we report that upregulation of
Larsen, Rasmus, Appelberg, Rui, Sandro Silva Gomes, Rasmus Larsen, Miguel Parreira Soares, Soares, Miguel Parreira, Maria Salome Gomes, Silva-Gomes, Sandro, Gomes, Maria Salomé, Rui Appelberg, Sandro Silva-Gomes   +10 more
core   +1 more source

Metformin alleviates spinal cord injury by inhibiting nerve cell ferroptosis through upregulation of heme oxygenase-1 expression

Neural Regeneration Research
[INLINE:1] Previous studies have reported upregulation of heme oxygenase-1 in different central nervous system injury models. Heme oxygenase-1 plays a critical anti-inflammatory role and is essential for regulating cellular redox homeostasis.
Zhihua Wang, Wu Zhou, Zhixiong Zhang, Lulu Zhang, Meihua Li   +4 more
doaj   +1 more source

Curcumin and Heme Oxygenase: Neuroprotection and Beyond [PDF]

International Journal of Molecular Sciences, 2019
Curcumin is a natural polyphenol component of Curcuma longa Linn, which is currently considered one of the most effective nutritional antioxidants for counteracting free radical-related diseases. Several experimental data have highlighted the pleiotropic neuroprotective effects of curcumin, due to its activity in multiple antioxidant and anti ...
Emanuela Mhillaj, Andrea Tarozzi, Letizia Pruccoli, Vincenzo Cuomo, Luigia Trabace, Cesare Mancuso   +5 more
openaire   +3 more sources