Results 11 to 20 of about 64,285 (304)

Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1. [PDF]

PLoS ONE, 2013
The single nucleotide polymorphism rs2071746 and a (GT)n microsatellite within the human gene encoding heme oxygenase-1 (HMOX1) are associated with incidence or outcome in a variety of diseases.
Marcel Kramer, Christoph Sponholz, Monique Slaba, Bianka Wissuwa, Ralf A Claus, Uwe Menzel, Klaus Huse, Matthias Platzer, Michael Bauer   +8 more
doaj   +1 more source

Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

Haematologica, 2012
Heme-oxygenase 1 is an endoplasmic reticulum-anchored enzyme that breaks down heme into iron, carbon monoxide and biliverdin. Heme is a hydrophobic co-factor in many proteins, including hemoglobin.
Yehonatan Gottlieb, Marianna Truman, Lyora A. Cohen, Yael Leichtmann-Bardoogo, Esther G. Meyron-Holtz   +4 more
doaj   +1 more source

Early Serum Heme Oxygenase-1, Soluble Vascular Endothelial Growth Factor Receptor-1, and B-Cell Lymphoma/Leukemia-2 Levels and Unfavorable Obstetric Outcomes

Gynecology Obstetrics & Reproductive Medicine, 2022
OBJECTIVE: To examine early pregnancy levels of serum heme oxygenase-1, soluble vascular endothelial growth factor receptor-1, B-cell lymphoma/leukemia-2 in relation to unfavorable pregnancy outcomes, including preeclampsia, fetal growth restriction ...
Havva Sutcu, G. Fusun Varol, Cihan Inan, Isil Uzun, N.Cenk Sayin   +4 more
doaj   +1 more source

HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children. [PDF]

, 2012
Heme oxygenase 1 (HO-1) is an essential enzyme induced by heme and multiple stimuli associated with critical illness. In humans, polymorphisms in the HMOX1 gene promoter may influence the magnitude of HO-1 expression.
Madi Njie (177625), Walther, Brigitte, Cunnington, A., De Caul, A, Sebastian Weis, Ebonyi, A., Deininger Susanne, Aka Peter, Deininger, S., Peter Aka, Takem, Ebako N, Predazzi, Irene M, Conway David J., Predazzi, IM, Cunnington, Aubrey, Walther, Michael, Conway, DJ, Aubrey Cunnington, Njie, M., Predazzi, I. M., Weis Sebastian, Augustine Ebonyi (177659), Sarah Rowland-Jones, Walther Michael, Amambua-Ngwa, A., Sarah Rowland-Jones (74678), Scott M. Williams (177668), Robert Walton, Susanne Deininger (173844), Sirugo, G, Cunnington Aubrey, Njie, Madi, Williams Scott M., Sirugo, Giorgio, Weis, S, Augustine Ebonyi, Walton Robert, Aka, P, Aka, P., Rowland-Jones Sarah, Williams, Scott M, Williams, S. M., Ebonyi, A, Alfred Amambua-Ngwa (122336), Weis, Sebastian, De Caul, Adam, Williams, SM, Sebastian Weis (161447), Amambua-Ngwa Alfred, Takem Ebako N., Deininger, Susanne, Adam De Caul (177612), Giorgio Sirugo, Ebako N. Takem (177656), Amambua-Ngwa, A, Walton, Robert T., Ebonyi, Augustine, Alfred Amambua-Ngwa, Madi Njie, Michael Walther, Rowland-Jones, S., Giorgio Sirugo (62489), Aka, Peter, Walton, R, Njie, M, De Caul Adam, Njie Madi, Rowland-Jones, Sarah, Takem, EN, Predazzi Irene M., Takem, E. N., Robert Walton (177664), Amambua-Ngwa, Alfred, Conway, D. J., Adam De Caul, Walther, B., Weis, S., Deininger, S, Susanne Deininger, Aubrey Cunnington (177640), Conway, David J, Peter Aka (177618), Sirugo, G., Ebako N Takem, David J Conway, David J. Conway (34880), de Caul, A., Irene M. Predazzi (177634), Brigitte Walther (130764), Walther, M, Walther, M., Walther Brigitte, Walton, Robert, Cunnington, A, Scott M Williams, Irene M Predazzi, Sirugo Giorgio, Walther, B, Rowland-Jones, S, Brigitte Walther, Michael Walther (130767), Ebonyi Augustine   +101 more
core   +1 more source

Subarachnoid Hemorrhage Increases Level of Heme Oxygenase-1 and Biliverdin Reductase in the Choroid Plexus

Frontiers in Cellular Neuroscience, 2020
Subarachnoid hemorrhage is a specific, life-threatening form of hemorrhagic stroke linked to high morbidity and mortality. It has been found that the choroid plexus of the brain ventricles forming the blood-cerebrospinal fluid barrier plays an important ...
Peter Solár, Peter Solár, Peter Solár, Václav Brázda, Václav Brázda, Shahaf Levin, Alemeh Zamani, Radim Jančálek, Radim Jančálek, Petr Dubový, Marek Joukal   +10 more
doaj   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Heme oxygenase in pregnancy and preeclampsia [PDF]

Current Opinion in Nephrology and Hypertension, 2013
Emerging evidence supports an important role for the heme oxygenase system in the maintenance of a healthy pregnancy. This review attempts to collect these wide-ranging data and summarize the recent progress in the field.New studies looking at heme oxygenase depletion in a variety of animal models have demonstrated that the heme oxygenase system is an ...
Eric M, George, Joey P, Granger
openaire   +2 more sources

Heme Oxygenase and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Overproduction of reactive oxygen species under pathophysiological conditions, including dyslipidemia, hypertension, diabetes, and smoking, is integral in the development of cardiovascular diseases (CVD). The reactive oxygen species released from all types of vascular cells regulate various signaling pathways that mediate not only vascular inflammation
openaire   +2 more sources

Nuclear Factor-κB-Independent Anti-Inflammatory Action of Salicylate in Human Endothelial Cells [PDF]

, 2006
In contrast to aspirin, salicylate, its active metabolite, possesses profound anti-inflammatory properties without blocking cyclooxygenase. Inhibition of the transcription factor nuclear factor-κB (NF-κB) has been discussed to play a role in the anti ...
Blumenthal, Signe B., Vollmar, Angelika M., Kiemer, Alexandra K., Zahler, Stefan, Fürst, Robert   +4 more
core   +1 more source

Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury

Antioxidants, 2021
Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of ...
Maria G. Detsika, Elias A. Lianos
doaj   +1 more source