Results 11 to 20 of about 115,890 (298)
Heme oxygenase-like dimetal oxidases and oxygenases. [PDF]
Biochem Soc TransAbstract The first heme oxygenase-like dimetal oxidase/oxygenase (HDO) was functionally validated through coordinated spectroscopic and rapid kinetic studies of the fatty acid decarboxylase UndA. The enzyme superfamily has since been recognized to orchestrate a variety of substrate transformations for natural product biosynthesis.
Skirboll SS, Ledinina AE, Makris TM.
europepmc +3 more sources
Heme Oxygenase-Like Metalloenzymes. [PDF]
Annu Rev BiochemHeme oxygenase (HO)-like metalloenzymes are an emerging protein superfamily diverse in reaction outcome and mechanism. Found primarily in bacterial biosynthetic pathways, members conserve a flexible protein scaffold shared with the heme catabolic enzyme, HO, and a set of metal-binding residues.
Pope SR +6 more
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Heme and immunity: The heme oxygenase dichotomy. [PDF]
J Inorg BiochemHeme, an iron containing organic ring, is required for a diverse range of biological processes across all forms of life. Although this nutrient is essential, its pro-inflammatory and cytotoxic properties can lead to cellular damage. Heme oxygenase 1 (HO-1) is an endoplasmic reticulum (ER)-anchored enzyme that degrades heme, releasing equimolar amounts ...
Perry M, Hamza I.
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Evidence for Heme Oxygenase Activity in a Heme Peroxidase
Biochemistry, 2009 The heme peroxidase and heme oxygenase enzymes share a common heme prosthetic group but catalyze fundamentally different reactions, the first being H(2)O(2)-dependent oxidation of substrate using an oxidized Compound I intermediate, and the second O(2)-dependent degradation of heme.
Badyal, SK +9 more
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Journal of Microbiology, Immunology and Infection, 2021 Increased heme levels, anemia, and desaturation occur during infection. We aimed to compare the levels of heme, heme oxygenase-1 (HO-1), ferritin, and bilirubin in coronavirus disease 2019 (COVID-19) patients at different saturation levels. Heme and HO-1
Wen-Lin Su +2 more
exaly +3 more sources
Immunolocalization of heme oxygenase-1 in periodontal diseases
Indian Journal of Dental Research, 2014 Context: Chronic periodontitis is an inflammatory condition of supporting tissues initiated by organisms in dental plaque. The reactive oxygen species and free radicals mediate connective tissue destruction in periodontitis.
G Gayathri +3 more
doaj +2 more sources
Heme oxygenase-1 and malaria pathogenesis [PDF]
Frontiers in ImmunologyMalaria is a life-threatening parasitic disease and remains a major cause of morbidity and mortality worldwide. The clinical course of malaria ranges from uncomplicated infection to severe disease, driven by extensive hemolysis, inflammation, and ...
Theophilus Wakai +4 more
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Immune-Related Functions of Heme Oxygenase-1
Antioxidants, 2023 Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]
Elias A. Lianos, Maria G. Detsika
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Heme oxygenase 1 overexpression increases iron fluxes in Caco-2 cells [PDF]
Biological Research, 2006 Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe.
MARÍA JOSE MENDIBURO +3 more
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Editorial: The heme oxygenase system in immunity [PDF]
Frontiers in ImmunologyDiego L. Costa +2 more
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