Results 101 to 110 of about 157,133 (211)

The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Biology, 2020
Background: Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production.
Fatma M. Ghoneim, Hani Alrefai, Ayman Z. Elsamanoudy, Salwa M. Abo El-khair, Hanaa A. Khalaf   +4 more
doaj   +1 more source

Curcumin and saroglitazar attenuate diet-induced nonalcoholic steatohepatitis by activating the Nrf2 pathway and suppressing ERK1/2 signaling [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Non-alcoholic fatty liver disease (NAFLD) is a chronic steatohepatitis disorder. If left untreated, it can progress to hepatocellular carcinoma.
Reza Afarin, Negar Dinarvand, Hossein Azizi Dariuni, Ghazal Orak, Bahar Jaberian Asl, Reza Azizi, Azam Khedri   +6 more
doaj   +1 more source

Sulforaphane-Induced Klf9/Prdx6 Axis Acts as a Molecular Switch to Control Redox Signaling and Determines Fate of Cells

Cells, 2019
Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis. We previously observed that
Bhavana Chhunchha, Eri Kubo, Dhirendra P. Singh   +2 more
doaj   +1 more source

Nrf2 Expression in CML and AML Patients’ Peripheral Blood Mononuclear Cells Treated by Vitamin D, Carnosic Acid and Curcumin

Journal of Pure and Applied Microbiology, 2018
The following study demonstrated the influence of 1,25D/CA and 1,25D/CUR combinations on Nrf2 expression in primary leukemic cells derived from newly diagnosed CML and AML patients of hematological department of Karaganda Regional Clinical Hospital ...
A.G. Zhumina, G.P. Pogossyan, K.G. Li, A.A. Konovalova, A.E. Konkabayeva, M.A. Mukasheva, G.M. Tykezhanova, N.M. Duzbayeva, S.S. Shorin, A.B. Yeshmagambetova   +9 more
doaj   +1 more source

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Nature, 2011
Reactive oxygen species (ROS) are mutagenic and may thereby promote cancer. Normally, ROS levels are tightly controlled by an inducible antioxidant program that responds to cellular stressors and is predominantly regulated by the transcription factor ...
G. DeNicola, F. Karreth, Timothy J. Humpton, A. Gopinathan, Cong Wei, K. Frese, Dipti Mangal, Kenneth H. Yu, C. Yeo, Eric S. Calhoun, F. Scrimieri, J. Winter, R. Hruban, C. Iacobuzio-Donahue, S. Kern, I. Blair, D. Tuveson   +16 more
semanticscholar   +1 more source

HP1 induces ferroptosis of renal tubular epithelial cells through NRF2 pathway in diabetic nephropathy

Open Life Sciences, 2023
Zhou Chuanqiang, Wu Min, Liu Gaolun, Zhou Li   +3 more
doaj   +1 more source

Brain Mitochondria as a Therapeutic Target for Carnosic Acid

Journal of Integrative Neuroscience
Carnosic acid (CA), a diterpene obtained mainly from Rosmarinus officinalis and Salvia officinalis, exerts antioxidant, anti-inflammatory, and anti-apoptotic effects in mammalian cells.
Vittoria Infantino, Ilaria Pappalardo, Anna Santarsiero, Swapnil Tripathi, Gyanendra Singh, Marcos Roberto de Oliveira   +5 more
doaj   +1 more source

Whole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer’s Disease

Journal of Inflammation Research, 2021
Elena Milanesi,1,* Maria Dobre,1,* Cătălina Anca Cucos,1 Ana I Rojo,2– 5 José Jiménez-Villegas,2,3 Estibaliz Capetillo-Zarate,5– 7 Carlos Matute,6,7 Gerard Piñol-Ripoll,8 Gina Manda,1 Antonio Cuadrado1– 5 1“Victor Babes” National ...
Milanesi E, Dobre M, Cucos CA, Rojo AI, Jiménez-Villegas J, Capetillo-Zarate E, Matute C, Piñol-Ripoll G, Manda G, Cuadrado A   +9 more
doaj  

Evidence of altered redox homeostasis in trichothiodystrophy

Redox Experimental Medicine
Objective: Trichothiodystrophy (TTD) is a rare hereditary disease whose prominent feature is brittle hair. Additional clinical signs are physical and neurodevelopmental abnormalities and in about half of the cases hypersensitivity to UV radiation ...
Valeria Cordone, Anna Guiotto, Vivian Bucay, Alessandra Pecorelli, Giuseppe Valacchi   +4 more
doaj   +1 more source

Sinomenine Ameliorates IL-1β-Induced Intervertebral Disc Degeneration in Rats Through Suppressing Inflammation and Oxidative Stress via Keap1/Nrf2/NF-κB Signaling Pathways

Journal of Inflammation Research, 2023
Gongbiao Lu,1,2,* Cunxin Zhang,2,* Kang Li,2 Kai Gao,3 Maoqing Fu,2 Chaoliang Lyu,2 Zhengxue Quan1 1Department of Spine Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400042, People’s Republic of China ...
Lu G, Zhang C, Li K, Gao K, Fu M, Lyu C, Quan Z   +6 more
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