Results 101 to 110 of about 197,106 (353)
The Nrf2-HO-1 system and inflammaging
Frontiers in ImmunologyNrf2 is a master transcriptional regulator of a number of genes involved in the adaptive response to oxidative stress. Among the genes upregulated by Nrf2, heme oxygenase-1 (HO-1) has received significant attention, given that the products of HO-1 ...
S. O'Rourke, L. Shanley, A. Dunne
semanticscholar +1 more source
Nrf2and Cardiovascular Defense [PDF]
Oxidative Medicine and Cellular Longevity, 2013 The cardiovascular system is susceptible to a group of diseases that are responsible for a larger proportion of morbidity and mortality than any other disease. Many cardiovascular diseases are associated with a failure of defenses against oxidative stress-induced cellular damage and/or death, leading to organ dysfunction.
openaire +2 more sources
Hypoxia preconditioning promotes endurance exercise capacity of mice by activating skeletal muscle Nrf2 [PDF]
, 2019 Elite endurance athletes are used to train under hypoxic/high altitude conditions, which can elicit certain stress responses in skeletal muscle and helps to improve their physical performance.
Yang, Simin +7 more
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Cellular Modulators of the NRF2/KEAP1 Signaling Pathway in Prostate Cancer
Frontiers in Bioscience-Landmark, 2023 Prostate cancer is the second most common malignancy in men worldwide. Prostate cancer can be treated by surgery, radiotherapy and hormone therapy. The latter, in the form of androgen-deprivation therapy is needed to reduce prostate cancer progression at
Giovanni Tossetta +3 more
doaj +1 more source
Keap-Nrf2-ARE single pathway [45].
, 2019 Activated Nrf2 entered the cell nucleus after dissociating from Keap1 suppressing protein, and combined with Maf protein in the nucleus to form a heterodimer and then combined with ARE DNA sequence, therefore, initiated gene transcription controlled by ...
Yaping Liu (165967) +6 more
core +1 more source
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation [PDF]
, 2012 Abnormal cellular accumulation of the dicarbonyl metabolite MG (methylglyoxal) occurs on exposure to high glucose concentrations, inflammation, cell aging and senescence.
Rabbani, Naila +10 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Translational Neuroscience, 2021 This study aimed to explore the role of miR-380-5p in cerebral ischemia/reperfusion (CIR) injury-induced neuronal cell death and the potential signaling pathway involved.
Wang Yibiao, Xu Min
doaj +1 more source
The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2.
Cell Reports, 2023 The redox regulator NRF2 becomes activated upon oxidative and electrophilic stress and orchestrates a response program associated with redox regulation, metabolism, tumor therapy resistance, and immune suppression.
J. Kreß +9 more
semanticscholar +1 more source