Results 61 to 70 of about 157,133 (211)

Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
The present study aimed to investigate whether dexmedetomidine (Dex) exerts cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury (MIRI) was induced in Sprague-Dawley rats in Langendorff preparation.
Zhuoran Wang, Mengran Yao, Leyu Jiang, Lingyan Wang, Yuqiao Yang, Quan Wang, Xi-jing Qian, Yu Zhao, Jinqiao Qian   +8 more
semanticscholar   +1 more source

Nrf2 and the Nrf2-Interacting Network in Respiratory Inflammation and Diseases [PDF]

, 2020
Atmospheric pollutants and cigarette smoke influence the human respiratory system and induce airway inflammation, injury, and pathogenesis. Activation of the NF-E2-related factor 2 (Nrf2) transcription factor and downstream antioxidant response element (ARE)-mediated transcriptions play a central role in protecting respiratory cells against reactive ...
Carlson, Jennifer, Price, Lindsey, Deng, Huai   +2 more
openaire   +1 more source

Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer

Experimental and Molecular Medicine
Oxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy production. Cells adapt to varying oxygen levels through intricate response systems. Hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, orchestrate the
Taegeun Bae, S. Hallis, Mi-Kyoung Kwak
semanticscholar   +1 more source

Nrf2/Keap1/ARE signaling: Towards specific regulation

Life Science, 2021
The Nrf2 transcription factor governs the expression of hundreds genes involved in cell defense against oxidative stress, the hallmark of numerous diseases such as neurodegenerative, cardiovascular, some viral pathologies, diabetes and others.
A. V. Ulasov, A. A. Rosenkranz, G. Georgiev, A. S. Sobolev   +3 more
semanticscholar   +1 more source

OROPHARYNGEAL ADMINISTRATION OF POLYSTYRENE MICROPLASTICS INDUCES PROFIBROTIC AND OXIDATIVE CHANGES IN MURINE LUNG TISSUE

Проблеми екології та медицини
Aim: This study investigated the early pulmonary effects of intratracheally administered polystyrene microplastics (PS-MPs) in mice. Recognizing the emerging health concern of atmospheric microplastic inhalation, the research focused on identifying ...
Ye.V. Rybalchenko, A.V. Kabaliei, V.V. Palchyk, V.I. Shynkevych, I.P. Kaidashev   +4 more
doaj   +1 more source

Ethanol Impairs NRF2/Antioxidant and Growth Signaling in the Intact Placenta In Vivo and in Human Trophoblasts

Biomolecules, 2019
NRF2 is a redox-sensitive transcription factor that depending on the duration or magnitude of the stress, either translocates to the nucleus (beneficial) or is degraded in the cytosol (harmful). However, the role of NRF2-based mechanism(s) under ethanol (
Sambantham Shanmugam, Dhyanesh Patel, John M. Wolpert, Caezaan Keshvani, Xiaobo Liu, Susan E. Bergeson, Srivatsan Kidambi, Lenin Mahimainathan, George I. Henderson, Madhusudhanan Narasimhan   +9 more
doaj   +1 more source

Acacetin alleviates neuroinflammation and oxidative stress injury via the Nrf2/HO-1 pathway in a mouse model of spinal cord injury

Translational Neuroscience, 2022
Spinal cord injury (SCI) is a severe central nervous system disease, which may cause serious locomotor deficit. Acacetin is a flavone that possesses antioxidant and anti-inflammatory effects in different human diseases. The main purpose of this study was
Zhang Xin, Xu Lijun, Chen Xiang, Zhou Xianjie, Cao Lanhua   +4 more
doaj   +1 more source

Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway

Frontiers in Physiology, 2022
Ambient air temperature is a key factor affecting human health. Long-term exposure to a cold environment can cause various diseases, while the impact on the intestine, the organ which has the largest contact area with the external environment, cannot be ...
Jingru Guo, Huijie Hu, Zhuo Chen, Jing Xu, Junshu Nie, Jingjing Lu, Li Ma, Hong Ji, Jianbin Yuan, Bin Xu   +9 more
doaj   +1 more source

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress*

Journal of Biological Chemistry, 2009
A major mechanism in the cellular defense against oxidative or electrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which controls the expression of genes whose protein products are involved in the detoxication ...
Truyen Nguyen, P. Nioi, C. B. Pickett
semanticscholar   +1 more source

Nrf2: not “lost in translation”

Aging, 2016
Multiple myeloma (MM) is a clonal plasma cell malignancy which is frequently diagnosed in patients over 65 years of age. Because of an aging population, the incidence of MM has increased nearly 1 percent annually since 1975 and it is anticipated that the number of cases will nearly double by 2034 [1].
Hawley, Robert G., Riz, Irene
openaire   +2 more sources