Results 61 to 70 of about 197,106 (353)
Opposing effects of Nrf2 and Nrf2‐activating compounds on the NLRP3 inflammasome independent of Nrf2‐mediated gene expression [PDF]
European Journal of Immunology, 2017 The transcription factor Nrf2 regulates the expression of genes required for protection from xenobiotic and oxidative stress. Under normal conditions Nrf2 is constantly degraded upon ubiquitination, mediated by the Nrf2 inhibitor Keap1. Inflammasomes represent stress‐induced protein complexes.
Garstkiewicz, Martha +7 more
openaire +4 more sources
NRF2 signaling in cytoprotection and metabolism
British Journal of Pharmacology, 2023 The KEAP1-NRF2 system plays a central role in cytoprotection and defense mechanisms against oxidative stress. Because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and because NRF2 is a transcriptional factor regulating genes involved in the sulfur-mediated redox reactions, the KEAP1-NRF2 system has been regarded as a ...
Shohei Murakami +4 more
openaire +2 more sources
Nrf2-downstream genes with ARE in their promoter are up-regulated by RIC.
, 2021 Nrf2-downstream genes with ARE in their promoter are up-regulated by RIC.
Si Yuan Dai (11751839) +9 more
core +1 more source
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
Frontiers in Cell and Developmental Biology, 2022 Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two.
Wen Gao +7 more
semanticscholar +1 more source
Polymorphisms of Nrf2, an Antioxidative Gene, are Associated with Blood Pressure in Japanese [PDF]
, 2014 2014-02Nuclear factor-erythroid 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor that regulates the expression of antioxidant genes by activating Nrf2-antioxidant response element (ARE) pathway.
SHIMOYAMA, YASUHIKO +3 more
core +1 more source
Drug Design, Development and Therapy, 2023 Tao Yang,1– 4 Haiqiong Liu,1,3,4 Chaobo Yang,1,3,4 Huaqiang Mo,1,3,4 Xianbao Wang,1,3,4 Xudong Song,1,3,4 Luping Jiang,2 Ping Deng,2 Ran Chen,2 Pengcui Wu,2 Aihua Chen,1,3,4 Jing Yan1,3,4 1Department of Cardiology, Heart Center, Zhujiang Hospital ...
Yang T +11 more
doaj
Research Progress of Nrf2 and Ferroptosis in Tumor Drug Resistance
Chinese Journal of Lung Cancer, 2023 Lung cancer is one of the most common cancers in the world, and its treatment strategy is mainly surgery combined with radiotherapy and chemotherapy. However, long-term chemotherapy will result in drug resistance, which is also one of the difficulties in
Shuning HU +5 more
doaj +1 more source
A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90
Disease Models & Mechanisms, 2022 Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interactions
Vy Ngo +5 more
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Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke
Antioxidants, 2022 Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain, which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc.
Lei Wang +7 more
semanticscholar +1 more source
Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
Redox Biology, 2022 The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely ...
Sheng-Nan Liu, J. Pi, Qiang Zhang
semanticscholar +1 more source