Results 1 to 10 of about 3,730,172 (143)

Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children [PDF]

Frontiers in Immunology, 2018
Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek, Anna E. van Beek, Angela Kamp, Simone Kruithof, Ed J. Nieuwenhuys, Diana Wouters, Ilse Jongerius, Theo Rispens, Taco W. Kuijpers, Taco W. Kuijpers, Kyra A. Gelderman   +10 more
doaj   +4 more sources

The interaction between factor H and Von Willebrand factor. [PDF]

PLoS ONE, 2013
Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS).
Shuju Feng, Xiaowen Liang, Miguel A Cruz, Hangoc Vu, Zhou Zhou, Naresh Pemmaraju, Jing-Fei Dong, Michael H Kroll, Vahid Afshar-Kharghan   +8 more
doaj   +4 more sources

The human factor H protein family – an update [PDF]

Frontiers in Immunology
Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes.
Noémi Sándor, Noémi Sándor, Andrea E. Schneider, Alexandra T. Matola, Veronika H. Barbai, Dániel Bencze, Hani Hashim Hammad, Alexandra Papp, Dorottya Kövesdi, Dorottya Kövesdi, Barbara Uzonyi, Barbara Uzonyi, Mihály Józsi, Mihály Józsi   +13 more
doaj   +2 more sources

Complement factor H in molecular regulation of angiogenesis [PDF]

Medical Review
Angiogenesis, the process of formation of new capillaries from existing blood vessels, is required for multiple physiological and pathological processes.
Li Jiang, Wang Kaili, Starodubtseva Maria N., Nadyrov Eldar, Kapron Carolyn M., Hoh Josephine, Liu Ju   +6 more
doaj   +2 more sources

Bactericidal human monoclonal antibody 1B1 shows specificity for meningococcal factor H binding protein variant 2 and displaces human factor H [PDF]

FASEB BioAdvances
Thousands of disease cases and hundreds of deaths occur globally each year due to invasive meningococcal disease. Neisseria meningitidis serogroup B (MenB) is the leading cause of such disease in developed countries.
Daniele Veggi, Chelsy C. Chesterman, Laura Santini, Ying Huang, Nicola Pacchiani, Jeannette Sierra, Lynn Chen, Jason Laliberte, Federica Bianchi, Roberta Cozzi, Elisabetta Frigimelica, Domenico Maione, Oretta Finco, Matthew J. Bottomley   +13 more
doaj   +2 more sources

Cloning, expression and purification of the factor H binding protein and its interaction with factor H

Iranian Journal of Microbiology, 2016
Background and Objective: Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The factor H binding protein (fHBP) is a key virulence factor of Neisseria meningitidis that is able to selectively bind to human factor H, the key ...
Fatemeh Yarian, Mojgan Bandehpour, Negar Seyed, Bahram kazemi   +3 more
doaj   +2 more sources

Autoantibodies Against Factor B and Factor H Without Pathogenic Effects in a Patient with Immune Complex-Mediated Membranoproliferative Glomerulonephritis [PDF]

Biomedicines
Background: Membranoproliferative glomerulonephritis (MPGN) is an umbrella term for chronic disorders affecting the glomeruli. MPGN is often accompanied by the presence of autoantibodies against complement components.
Alexandra T. Matola, Dorottya Csuka, Ágnes Szilágyi, Michael Rudnicki, Zoltán Prohászka, Mihály Józsi, Barbara Uzonyi   +6 more
doaj   +2 more sources

Anti-factor H autoantibody-associated hemolytic uremic syndrome in an Argentine pediatric cohort

Exploration of Immunology, 2023
Aim: To describe the clinical characteristics and frequency of anti-factor H (FH) autoantibody-associated atypical hemolytic uremic syndrome (aHUS) in the first cohort of Argentine patients. Methods: The presence of anti-FH autoantibodies in 70 pediatric
Célia Dos Santos, Jesica Trinidad, Santiago Castera, Laura Alconcher, Paula Alejandra Coccia, Federico Javier Manni, María Fabiana Alberto, Analía Sánchez-Luceros   +7 more
doaj   +1 more source

Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice

Frontiers in Immunology, 2021
C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP.
Ola Kamala, Talat H. Malik, Thomas M. Hallam, Thomas E. Cox, Yi Yang, Falguni Vyas, Saimir Luli, Chloe Connelly, Beth Gibson, Kate Smith-Jackson, Harriet Denton, Isabel Y. Pappworth, Lei Huang, David Kavanagh, Matthew C. Pickering, Kevin J. Marchbank   +15 more
doaj   +1 more source

Hijacking Factor H for Complement Immune Evasion

Frontiers in Immunology, 2021
The complement system is an essential player in innate and adaptive immunity. It consists of three pathways (alternative, classical, and lectin) that initiate either spontaneously (alternative) or in response to danger (all pathways). Complement leads to
Sara R. Moore, Smrithi S. Menon, Claudio Cortes, Viviana P. Ferreira   +3 more
doaj   +1 more source