Results 11 to 20 of about 3,730,271 (242)
Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Frontiers in Immunology, 2021 Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars +11 more
doaj +1 more source
OncoImmunology, 2020 Macrophages are a major immune cell type in the tumor microenvironment, where they display a tumor-supporting phenotype. Factor H (FH) is a complement inhibitor that also plays a role in several cellular functions.
Karolina I. Smolag +8 more
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Human Vaccines & Immunotherapeutics, 2020 Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.
Peter T. Beernink
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Factor H Autoantibodies and Complement-Mediated Diseases
Frontiers in Immunology, 2020 Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180–420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces.
Yuzhou Zhang +10 more
doaj +1 more source
Factor H and Neisserial pathogenesis [PDF]
Vaccine, 2008 Both Neisseria gonorrhoeae and N. meningitidis bind to factor H which enhances their ability to evade complement-dependent killing. While porin is the ligand for human fH on gonococci, meningococci use a lipoprotein called factor H binding protein (fHbp) to bind to factor H and enhance their ability to evade complement-dependent killing.
Jo Anne, Welsch, Sanjay, Ram
openaire +2 more sources
The Electronic Journal of Combinatorics, 2006 An $H$-factor of a graph $G$ is a spanning subgraph of $G$ whose connected components are isomorphic to $H$. Given a properly edge-colored graph $G$, a rainbow $H$-subgraph of $G$ is an $H$-subgraph of $G$ whose edges have distinct colors. A rainbow $H$-factor is an $H$-factor whose components are rainbow $H$-subgraphs.
openaire +2 more sources
The effect of human factor H on immunogenicity of meningococcal native outer membrane vesicle vaccines with over-expressed factor H binding protein. [PDF]
PLoS Pathogens, 2012 The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH.
Peter T Beernink +5 more
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Anti-factor H antibody and its role in atypical hemolytic uremic syndrome
Frontiers in Immunology, 2022 Atypical hemolytic uremic syndrome (aHUS) an important form of a thrombotic microangiopathy (TMA) that can frequently lead to acute kidney injury (AKI). An important subset of aHUS is the anti-factor H associated aHUS.
Rupesh Raina +8 more
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C3 Glomerulonephritis associated with Anti-complement Factor H Autoantibodies in an Adolescent Male: A Case Report [PDF]
Childhood Kidney Diseases, 2021 C3 glomerulonephritis (C3GN), a rare condition associated with dysregulation of the alternative pathway of the complement system, is histopathologically characterized by isolated or dominant C3 deposition in the renal glomeruli.
HyeSun Hyun +4 more
doaj +1 more source