Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies [PDF]
Frontiers in Immunology, 2021 Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Markus A. Loeven +10 more
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Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation [PDF]
Frontiers in Immunology, 2022 Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp +16 more
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Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children [PDF]
Frontiers in Immunology, 2018 Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek +10 more
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Identification of novel blood-borne soluble binding partners of factor H-related proteins [PDF]
Scientific ReportsThe deposition of circulating complement factor H-related (FHR) proteins in tissues around the body has been implicated in a series of complement-mediated diseases.
Jiaqi Tang +8 more
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Development and Characterization of Novel ELISAs for the Specific Quantification of the Factor H-Related Proteins 2, 3, 4, and 5 [PDF]
Journal of Innate ImmunityIntroduction: The complement system’s alternative pathway relies on factor H (FH) for immune homeostasis. Next to FH, a group of highly similar proteins was described known as the FH-related (FHR) proteins.
Mara van Rossum +14 more
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C3 Glomerulonephritis associated with Anti-complement Factor H Autoantibodies in an Adolescent Male: A Case Report [PDF]
Childhood Kidney Diseases, 2021 C3 glomerulonephritis (C3GN), a rare condition associated with dysregulation of the alternative pathway of the complement system, is histopathologically characterized by isolated or dominant C3 deposition in the renal glomeruli.
HyeSun Hyun +4 more
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Levels of soluble complement regulators predict severity of COVID-19 symptoms
Frontiers in Immunology, 2022 The SARS-CoV-2 virus continues to cause significant morbidity and mortality worldwide from COVID-19. One of the major challenges of patient management is the broad range of symptoms observed.
Anna L. Tierney +182 more
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Frontiers in Immunology, 2021 Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars +11 more
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Nefrología (English Edition), 2022 The complement system is a first line of defence against infectious, tumoral or autoimmune processes, and it is constitutively regulated to avoid excessive or unspecific activation. Factor H (FH), a most relevant complement regulator, controls complement
Irene Gómez Delgado +1 more
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Nefrología, 2022 Resumen: El sistema del Complemento protege al organismo frente a procesos infecciosos, tumorales y autoinmunes, y requiere una regulación muy estricta para evitar una activación excesiva o inespecífica.
Irene Gómez Delgado +1 more
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