Results 41 to 50 of about 26,183,286 (282)

CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Frontiers in Genetics, 2021
C3 Glomerulopathy (C3G) and Immune Complex-Mediated Membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases characterized by glomerular deposition of C3 caused by dysregulation of the alternative pathway (AP) of complement.
Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J. H. Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +12 more
doaj   +1 more source

Factor H family proteins and human diseases [PDF]

, 2008
Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins.
Peter F. Zipfel, Józsi, Mihály, Zipfel, P. F., Mihály Józsi   +3 more
core   +1 more source

Mechanism of Borrelia immune evasion by FhbA-related proteins.

PLoS Pathogens, 2022
Immune evasion facilitates survival of Borrelia, leading to infections like relapsing fever and Lyme disease. Important mechanism for complement evasion is acquisition of the main host complement inhibitor, factor H (FH). By determining the 2.2 Å crystal
Konstantin Kogan, Karita Haapasalo, Tommi Kotila, Robin Moore, Pekka Lappalainen, Adrian Goldman, Taru Meri   +6 more
doaj   +1 more source

Factor H‐related protein 1: a complement regulatory protein and guardian of necrotic‐type surfaces [PDF]

British Journal of Pharmacology, 2020
Factor H‐related protein 1 (FHR‐1) is a member of the factor H protein family, which is involved in regulating innate immune complement reactions. Genetic modification of the encoding gene, CFHR1 on human chromosome 1, is involved in diseases such as age‐related macular degeneration, C3 glomerulopathy and atypical haemolytic uraemic syndrome ...
Skerka, Christine, Pradel, Gabriele, Halder, Luke D., Zipfel, Peter F., Zipfel, Svante L. H., Strauß, Olaf   +5 more
openaire   +3 more sources

Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease [PDF]

Scientific Reports, 2021
AbstractAtherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellular necrosis, and complement activation, resulting in inflammation and thrombosis.
Irmscher, S., Zipfel, S., Halder, L., Ivanov, L., Gonzalez-Delgado, A., Waldeyer, C., Seiffert, M., Brunner, F., von der Heide, M., Loeschmann, I., Wulf, S., Czamara, D. ; https://orcid.org/0000-0001-7381-904X, Papac-Milicevic, N., Strauss, O., Lorkowski, S., Reichenspurner, H., Holers V, M., Banda, N., Zeller, T., Binder, E. ; https://orcid.org/0000-0001-7088-6618, Binder, C., Wiech, T., Zipfel, P., Skerka, C.   +23 more
openaire   +4 more sources

Blood-based protein biomarkers for the diagnosis of acute stroke: A discovery-based SWATH-MS proteomic approach

Frontiers in Neurology, 2022
Background and purposesRecent developments in high-throughput proteomic approach have shown the potential to discover biomarkers for diagnosing acute stroke and to elucidate the pathomechanisms specific to different stroke subtypes. We aimed to determine
Shubham Misra, Praveen Singh, Manabesh Nath, Divya Bhalla, Shantanu Sengupta, Amit Kumar, Awadh K. Pandit, Praveen Aggarwal, Achal K. Srivastava, Dheeraj Mohania, Kameshwar Prasad, Kameshwar Prasad, Deepti Vibha   +12 more
doaj   +1 more source

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie, Sonja Grosskinsky, Markus M. Simon, Grosskinsky, Sonja, Cutler, Sally J., Schott, M., Simon, M., Kraiczy, P., Zipfel, Peter F., Grosskinsky, S., Peter Kraiczy, Sally J Cutler, Peter F Zipfel, Peter F. Zipfel, Brenner, Christiane, Wallich, R., Kraiczy, Peter, Brenner, C., Christiane Brenner, Simon, Markus M., Markus M Simon, Wallich, Reinhard, Sally J. Cutler, Reinhard Wallich, Cutler, S., Zipfel, P., Melanie Schott, Schott Melanie, Kraiczy Peter, Grosskinsky Sonja, Simon Markus M., Cutler Sally J., Zipfel Peter F., Brenner Christiane, Wallich Reinhard   +34 more
core   +2 more sources

Regulation of regulators: Role of the complement factor H-related proteins

Seminars in Immunology, 2019
The complement system, while being an essential and very efficient effector component of innate immunity, may cause damage to the host and result in various inflammatory, autoimmune and infectious diseases or cancer, when it is improperly activated or regulated.
Cserhalmi, Marcell, Papp, A., Brandus, B., Uzonyi, Barbara, Józsi, Mihály   +4 more
openaire   +4 more sources

Human complement factor H. Two factor H proteins are derived from alternatively spliced transcripts [PDF]

, 1991
The human complement factor H is an important component in the control of the alternative pathway of complement activation. We have previously shown that at least three factor H homologous mRNA species of 4.3 kb, 1.8 kb and 1.4 kb in length are ...
Cornelia Estaller, Estaller, Cornelia, Schwaeble, Wilhelm, Manfred Dierich, Dierich, Manfred P., Weiss, Elisabeth H., Wilhelm Schwaeble, Elisabeth H. Weiss   +7 more
core   +1 more source

Complement factor H family proteins in their non-canonical role as modulators of cellular functions [PDF]

, 2019
Complement factor H is a major regulator of the alternative pathway of the complement system. The factor H-related proteins are less characterized, but recent data indicate that they rather promote complement activation.
Noémi Sándor, Éva Kárpáti, Kárpáti, Éva, Józsi, Mihály, Sándor, Noémi, Schneider, Andrea E., Mihály Józsi, Andrea E. Schneider   +7 more
core   +1 more source