Results 41 to 50 of about 1,408,273 (290)

Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity [PDF]

, 2009
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates.
Schott, Melanie, Sonja Grosskinsky, Markus M. Simon, Grosskinsky, Sonja, Cutler, Sally J., Schott, M., Simon, M., Kraiczy, P., Zipfel, Peter F., Grosskinsky, S., Peter Kraiczy, Sally J Cutler, Peter F Zipfel, Peter F. Zipfel, Brenner, Christiane, Wallich, R., Kraiczy, Peter, Brenner, C., Christiane Brenner, Simon, Markus M., Markus M Simon, Wallich, Reinhard, Sally J. Cutler, Reinhard Wallich, Cutler, S., Zipfel, P., Melanie Schott   +26 more
core   +1 more source

Regulation of regulators: Role of the complement factor H-related proteins

Seminars in Immunology, 2019
The complement system, while being an essential and very efficient effector component of innate immunity, may cause damage to the host and result in various inflammatory, autoimmune and infectious diseases or cancer, when it is improperly activated or regulated.
Cserhalmi, Marcell, Papp, A., Brandus, B., Uzonyi, Barbara, Józsi, Mihály   +4 more
openaire   +4 more sources

Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease [PDF]

Scientific Reports, 2021
AbstractAtherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellular necrosis, and complement activation, resulting in inflammation and thrombosis.
Irmscher, S., Zipfel, S., Halder, L., Ivanov, L., Gonzalez-Delgado, A., Waldeyer, C., Seiffert, M., Brunner, F., von der Heide, M., Loeschmann, I., Wulf, S., Czamara, D. ; https://orcid.org/0000-0001-7381-904X, Papac-Milicevic, N., Strauss, O., Lorkowski, S., Reichenspurner, H., Holers V, M., Banda, N., Zeller, T., Binder, E. ; https://orcid.org/0000-0001-7088-6618, Binder, C., Wiech, T., Zipfel, P., Skerka, C.   +23 more
openaire   +4 more sources

Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells [PDF]

, 1992
Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Schwaner, I., Frank, R., Gausepohl, H., Seifert, Roland, Schultz, Günter, Klinz, F. J.   +5 more
core   +1 more source

Evaluating the clinical utility of measuring levels of factor H and the related proteins [PDF]

, 2022
After years of disappointing clinical results, the tide has finally changed and complement targeted-therapies have become a validated and accepted treatment option for several diseases. These accomplishments have revitalized the field and brought renewed
Pouw, Richard B., SciFiMed Consortium, Banerjee, Pratiti, Veuskens, Bert R.J., Pouw, Richard B, Baeumner, Antje J., Baeumner, Antje J, Toonen, Erik J M, de Jorge, Elena Goicoechea, Toonen, Erik J.M., Pauly, Diana, Veuskens, Bert, Poppelaars, Felix, Steiner, Mark-Steven, Steiner, Mark Steven, Józsi, Mihály   +15 more
core   +1 more source

Factor H family proteins and human diseases [PDF]

, 2008
Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a protein family that includes CFHL1 and five factor H-related (CFHR) proteins.
Peter F. Zipfel, Józsi, Mihály, Zipfel, P. F., Mihály Józsi   +3 more
core   +1 more source

Recurrence of Complement Factor H-Related Protein 5 Nephropathy in a Renal Transplant [PDF]

American Journal of Transplantation, 2011
Complement factor H-related protein 5 (CFHR5) nephropathy is a familial renal disease endemic in Cyprus. It is characterized by persistent microscopic hematuria, synpharyngitic macroscopic hematuria and progressive renal impairment. Isolated glomerular accumulation of complement component 3 (C3) is typical with variable degrees of glomerular ...
Vernon, KA, Gale, DP, de Jorge, E Goicoechea, McLean, AG, Galliford, J, Pierides, A, Maxwell, PH, Taube, D, Pickering, MC, Cook, HT   +9 more
openaire   +2 more sources

Beyond factor H:The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations [PDF]

, 2021
Age-related macular degeneration (AMD) is a leading cause of vision loss; there is strong genetic susceptibility at the complement factor H (CFH) locus. This locus encodes a series of complement regulators: factor H (FH), a splice variant factor-H-like 1
Clark, Simon J, Clark, Simon J; id_orcid, Tierney, Anna, Griffiths, John R, Cipriani, Valentina, Moore, Anthony T, Sergouniotis, Panagiotis, Unwin, Richard D; id_orcid, Yates, John RW, Sergouniotis, Panagiotis I, Bishop, Paul N, Yates, John R W, Unwin, Richard D, Zuber, Verena, Sergouniotis, Panagiotis I; id_orcid   +14 more
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The Borrelia afzelii outer membrane protein BAPKO_0422 binds human Factor-H and is predicted to form a membrane-spanning beta-barrel [PDF]

, 2015
The deep evolutionary history of the Spirochetes places their branch point early in the evolution of the diderms, before the divergence of the present day Proteobacteria.
Brown, G., Bingham, Richard, Bingham, R.J., Stejskal, Lenka, Laity, Peter R., Dyer, A., Laity, P.R., Stejskal, L., Dyer, Adam, Brown, Gemma   +9 more
core   +1 more source

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

Frontiers in Immunology
Factor H-related proteins (FHRs) are found in mice, but their equivalence to human FHRs remains uncertain. This study identifies three FHRs in mouse plasma (FHR-B, FHR-C, and FHR-E) and focuses on characterizing FHR-B.
Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero   +6 more
doaj   +1 more source