Results 41 to 50 of about 2,205,533 (300)

Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency [PDF]

, 2008
Atypical hemolytic uremic syndrome (aHUS) is a severe renal disease that is associated with defective complement regulation caused by multiple factors.
Józsi, Mihály, Licht, C., Richter, H., Strobel, S., Zipfel, S. L.   +4 more
core   +1 more source

Complement factor H related proteins (CFHRs)

Molecular Immunology, 2013
Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2, CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central complement component C3b. Mutations, genetic deletions, duplications or rearrangements in the individual CFHR genes are associated with a number of diseases including atypical hemolytic uremic ...
Skerka, Christine, Chen, Qian, Fremeaux-Bacchi, Veronique, Roumenina, Lubka T.   +3 more
openaire   +2 more sources

Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]

, 2012
Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core   +1 more source

Maternal liver damage induced by cadmium exposure in pregnant mice through hypoxia inducible factor-1α-mediated upregulation in DRP1

环境与职业医学, 2023
BackgroundMitochondrial dynamin-related protein 1 (DRP1) regulates mitochondrial division and plays an important role in maintaining hepatocyte function. However, the role of DRP1 in cadmium exposure-induced maternal liver damage in pregnant mice remains
Limin DAI, Hualong ZHU, Yongwei XIONG, Weibo LIU, Guoxiang ZHOU, Shuang ZHANG, Zhengjia LING, Lulu TAN, Jin ZHANG, Yufeng ZHANG, Yiting FU, Daixin LI, Hua WANG   +12 more
doaj   +1 more source

Impaired interferon-γ responses, increased interleukin-17 expression, and a tumor necrosis factor–α transcriptional program in invasive aspergillosis [PDF]

, 2009
This article is available open access through the publisher’s website. Copyright @ 2009 Oxford University Press.Background - Invasive aspergillosis (IA) is the most common cause of death associated with fungal infection in the developed world ...
Armstrong-James, DP, Bignell, E, Haynes, K, Rogers, NJ, Rogers, TRF, Stark, J, Teo, I, Turnbull, SA   +7 more
core   +1 more source

FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation [PDF]

, 2017
Factor H (FH)-related protein 1 (FHR-1) is one of the five human factor H-related proteins, which share sequence and structural homology with the alternative pathway complement inhibitor FH.
Bánlaki, Zsófia, Cserhalmi, Marcell, Csincsi, Ádám, Józsi, Mihály, Kárpáti, Éva, Prohászka, Zoltán, Szabó, Z., Uzonyi, Barbara   +7 more
core   +1 more source

CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Frontiers in Genetics, 2021
C3 Glomerulopathy (C3G) and Immune Complex-Mediated Membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases characterized by glomerular deposition of C3 caused by dysregulation of the alternative pathway (AP) of complement.
Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J. H. Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +12 more
doaj   +1 more source

Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. [PDF]

, 2013
The sub-retinal pigment epithelial deposits (sRPEds) that are a hallmark of age-related macular degeneration (AMD) contain both C3b and mM levels of zinc.
Gor, J, Lengyel, I, Nan, R, Pao, PJ, Perkins, SJ, Rodriguez, E, Tetchner, S   +6 more
core   +1 more source

Mechanism of Borrelia immune evasion by FhbA-related proteins.

PLoS Pathogens, 2022
Immune evasion facilitates survival of Borrelia, leading to infections like relapsing fever and Lyme disease. Important mechanism for complement evasion is acquisition of the main host complement inhibitor, factor H (FH). By determining the 2.2 Å crystal
Konstantin Kogan, Karita Haapasalo, Tommi Kotila, Robin Moore, Pekka Lappalainen, Adrian Goldman, Taru Meri   +6 more
doaj   +1 more source

Blood-based protein biomarkers for the diagnosis of acute stroke: A discovery-based SWATH-MS proteomic approach

Frontiers in Neurology, 2022
Background and purposesRecent developments in high-throughput proteomic approach have shown the potential to discover biomarkers for diagnosing acute stroke and to elucidate the pathomechanisms specific to different stroke subtypes. We aimed to determine
Shubham Misra, Praveen Singh, Manabesh Nath, Divya Bhalla, Shantanu Sengupta, Amit Kumar, Awadh K. Pandit, Praveen Aggarwal, Achal K. Srivastava, Dheeraj Mohania, Kameshwar Prasad, Kameshwar Prasad, Deepti Vibha   +12 more
doaj   +1 more source