Results 51 to 60 of about 2,205,533 (300)

Facilitation of penicillin haptenation to serum proteins. [PDF]

, 1993
Traditionally, penicillin binding to serum proteins was believed to be a passive chemical process; however, it appears to be facilitated by serum factors.
Adkinson, N. Franklin, Jr., DiPiro, Joseph T., Hamilton, Robert G.   +2 more
core   +3 more sources

Factor H‐related protein 1: a complement regulatory protein and guardian of necrotic‐type surfaces [PDF]

British Journal of Pharmacology, 2020
Factor H‐related protein 1 (FHR‐1) is a member of the factor H protein family, which is involved in regulating innate immune complement reactions. Genetic modification of the encoding gene, CFHR1 on human chromosome 1, is involved in diseases such as age‐related macular degeneration, C3 glomerulopathy and atypical haemolytic uraemic syndrome ...
Skerka, Christine, Pradel, Gabriele, Halder, Luke D., Zipfel, Peter F., Zipfel, Svante L. H., Strauß, Olaf   +5 more
openaire   +3 more sources

A Proteomic Study of Memory After Imprinting in the Domestic Chick. [PDF]

, 2015
The intermediate and medial mesopallium (IMM) of the domestic chick forebrain has previously been shown to be a memory system for visual imprinting. Learning-related changes occur in certain plasma membrane and mitochondrial proteins in the IMM.
Margvelani, Giorgi, McCabe, Brian J, Meparishvili, Maia, Nozadze, Maia, Solomonia, Revaz O   +4 more
core   +2 more sources

Complement factor H–related hybrid protein deregulates complement in dense deposit disease [PDF]

Journal of Clinical Investigation, 2013
The renal disorder C3 glomerulopathy with dense deposit disease (C3G-DDD) pattern results from complement dysfunction and primarily affects children and young adults. There is no effective treatment, and patients often progress to end-stage renal failure.
Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF   +11 more
openaire   +3 more sources

Parkinson's disease plasma biomarkers: An automated literature analysis followed by experimental validation [PDF]

, 2013
Diagnosis of Parkinson's disease (PD) is currently assessed by the clinical evaluation of extrapyramidal signs. The identification of specific biomarkers would be advisable, however most studies stop at the discovery phase, with no biomarkers reaching ...
Alberio, Alberio, Alberio, Albrecht, Argüelles, Cannon, Costa-Mallen, Dario Bonino, Dufek, Edo Bottacchi, Enrico M. Bucci, Finehout, Frasier, Galicia, Gerlach, Goldknopf, Griss, Hu, Ioannidis, Jacob, Jacobs, Jankovic, Marco Di Giovanni, Massimo Natale, Mauro Fasano, McDonald, Morgan, Natale, Nicoletti, R Development Core Team, Riek-Burchardt, Rosenberg, Sheta, Shulman, Sokolova, Surinova, Tansey, Tiziana Alberio   +37 more
core   +1 more source

Mitochondrial and chloroplast stress responses are modulated in distinct touch and chemical inhibition phases [PDF]

, 2016
Previous studies have identified a range of transcription factors that modulate retrograde regulation of mitochondrial and chloroplast functions in Arabidopsis (Arabidopsis thaliana).
De Clercq, Inge, Ivanova, Aneta, Law, Simon R, Millar, A Harvey, Van Aken, Olivier, Van Breusegem, Frank, Whelan, James   +6 more
core   +2 more sources

Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease [PDF]

Scientific Reports, 2021
AbstractAtherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellular necrosis, and complement activation, resulting in inflammation and thrombosis.
Irmscher, S., Zipfel, S., Halder, L., Ivanov, L., Gonzalez-Delgado, A., Waldeyer, C., Seiffert, M., Brunner, F., von der Heide, M., Loeschmann, I., Wulf, S., Czamara, D., Papac-Milicevic, N., Strauss, O., Lorkowski, S., Reichenspurner, H., Holers V, M., Banda, N., Zeller, T., Binder, E., Binder, C., Wiech, T., Zipfel, P., Skerka, C.   +23 more
openaire   +4 more sources

Dexmedetomidine post-treatment attenuates cardiac ischaemia/reperfusion injury by inhibiting apoptosis through HIF-1α signalling. [PDF]

, 2020
Hypoxia-inducible factor 1α (HIF-1α) plays a critical role in the apoptotic process during cardiac ischaemia/reperfusion (I/R) injury. This study aimed to investigate whether post-treatment with dexmedetomidine (DEX) could protect against I/R-induced ...
Chen, Wei-Rong, Ji, Fu-Hai, Liu, Hong, Liu, Hua-Yue, Meng, Xiao-Wen, Peng, Ke, Xia, Fan, Xia, Zheng-Yuan, Zhang, Juan   +8 more
core  

Factor H–Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy

Journal of the American Society of Nephrology, 2022
Significance Statement Mutations in factor H–related protein 1 (FHR-1) that result in duplication of its dimerization domain associate with the chronic renal disease C3 glomerulopathy (C3G), which is characterized by complement dysregulation. The molecular basis for this association is only partially understood.
Márquez-Tirado, Bárbara, Gutiérrez-Tenorio, Josué, Tortajada, Agustín, Lucientes Continente, Laura, Caravaca-Fontán, Fernando, Malik, Talat H., Roldán Montero, Raquel, Elías, Sandra, Saiz Gonzalez, Ana, Fernández-Juarez, Gema, Sánchez-Corral, Pilar, Pickering, Matthew C., Praga, Manuel, Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena   +14 more
openaire   +4 more sources

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces [PDF]

Frontiers in Immunology, 2021
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remove the complement regulator FH from surfaces that strongly fix opsonic C3b molecules—a process known as “
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Britta Höchsmann, Hubert Schrezenmeier, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt   +10 more
openaire   +3 more sources