Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces [PDF]
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
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Glomerular Complement Factor H–Related Protein 5 is Associated with Histologic Injury in Immunoglobulin A Nephropathy [PDF]
Kidney International Reports, 2021 Introduction: Immunoglobulin A nephrology (IgAN), characterized by co-deposition of IgA and complement components, is an activation of complement system involved disease.
Wei-yi Guo +6 more
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Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease [PDF]
Scientific Reports, 2021 Atherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellular necrosis ...
Sarah Irmscher +23 more
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Factor H-related protein 1 in systemic lupus erythematosus [PDF]
Frontiers in ImmunologyBackgroundFactor H (FH) is a major soluble inhibitor of the complement system and part of a family comprising five related proteins (FHRs 1–5). Deficiency of FHR1 was described to be linked to an elevated risk of systemic lupus erythematosus (SLE).
Jessica S. Kleer +9 more
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The Murine Factor H-Related Protein FHR-B Promotes Complement Activation [PDF]
Frontiers in Immunology, 2017 Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi +6 more
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Human factor H-related protein 2 (CFHR2) regulates complement activation. [PDF]
PLoS ONE, 2013 Mutations and deletions within the human CFHR gene cluster on chromosome 1 are associated with diseases, such as dense deposit disease, CFHR nephropathy or age-related macular degeneration. Resulting mutant CFHR proteins can affect complement regulation.
Hannes U Eberhardt +10 more
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Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. [PDF]
PLoS ONE, 2016 Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been reported to regulate complement by blocking C5 convertase activity and interfering with C5b surface association. CFHR1 also competes with complement factor H (CFH) for
Jonathan P Hannan +4 more
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Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration [PDF]
Nature Communications, 2020 A locus on chromosome 1 encompassing the CFHR genes is highly associated with AMD risk. Here, Cipriani and colleagues investigate the role of CFHR4, encoding FHR-4, and demonstrate a relationship between AMD risk, circulating FHR-4 levels and genetic ...
Valentina Cipriani +16 more
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Role of factor H-related protein 3 in Pseudomonas aeruginosa bloodstream infections [PDF]
Frontiers in ImmunologyPseudomonas aeruginosa is a leading cause of nosocomial bloodstream infections. The outcome of these infections depends on the virulence of the microorganism as well as host-related conditions and factors.
Alex González-Alsina +7 more
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Factor H-related protein 1 promotes complement-mediated opsonization of Pseudomonas aeruginosa [PDF]
Frontiers in Cellular and Infection MicrobiologyPseudomonas aeruginosa is an important human opportunistic pathogen responsible for a wide range of infections. The complement system is the main early host defense mechanism to control these infections. P.
Alex González-Alsina +7 more
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