Results 21 to 30 of about 1,814,273 (138)

Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children [PDF]

Frontiers in Immunology, 2018
Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation. Impaired complement function due to aberrant plasma levels of complement proteins may be indicative for complement-mediated diseases or can be involved in susceptibility for ...
Anna E. van Beek, Anna E. van Beek, Angela Kamp, Simone Kruithof, Ed J. Nieuwenhuys, Diana Wouters, Ilse Jongerius, Theo Rispens, Taco W. Kuijpers, Taco W. Kuijpers, Kyra A. Gelderman   +10 more
openaire   +4 more sources

Modulation of the Alternative Pathway of Complement by Murine Factor H–Related Proteins [PDF]

The Journal of Immunology, 2018
Abstract Factor H (FH) is a key alternative pathway regulator that controls complement activation both in the fluid phase and on specific cell surfaces, thus allowing the innate immune response to discriminate between self and foreign pathogens.
Alexandra H Antonioli, Janice White, Frances Crawford, Brandon Renner, Kevin J Marchbank, Jonathan P Hannan, Joshua M Thurman, Philippa Marrack, V Michael Holers   +8 more
openaire   +5 more sources

Case Report: Severe Complement-Mediated Thrombotic Microangiopathy in IgG4-Related Disease Secondary to Anti-Factor H IgG4 Autoantibodies

Frontiers in Immunology, 2021
ObjectiveTo first describe and estimate the potential pathogenic role of Ig4 autoantibodies in complement-mediated thrombotic microangiopathy (TMA) in a patient with IgG4-related disease (IgG4-RD).MethodsThis study is a case report presenting a ...
Gautier Breville, Gautier Breville, Ido Zamberg, Ido Zamberg, Salima Sadallah, Caroline Stephan, Belen Ponte, Jörg D. Seebach   +7 more
doaj   +1 more source

Factor H related proteins modulate complement activation on kidney cells

Kidney International, 2022
Complement activation at a particular location is determined by the balance of activating and inhibitory proteins. Factor H is a key regulator of the alternative pathway of complement, and genetic or acquired impairments in Factor H are associated with glomerular injury. The human Factor H-related proteins (FHRs) comprise a family of five proteins that
Renner, B., Laskowski, J., Poppelaars, F., Ferreira, V.P., Blaine, J., Antonioli, A.H., Hannan, J.P., Kovacs, J.M., Kooten, C. van, You, Z.Y., Pickering, M.C., Holers, V.M., Thurman, J.M.   +12 more
openaire   +3 more sources

Factor H-related proteins determine complement-activating surfaces [PDF]

Trends in Immunology, 2015
Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation. Because FHRs are evolutionarily and structurally related to complement inhibitor factor H (FH), the initial assumption was that the FHRs are also
Józsi, Mihály, Tortajada, A., Uzonyi, Barbara, Goicoechea de, Jorge E., Rodriguez de Cordoba, S.   +4 more
openaire   +4 more sources

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies

Frontiers in Immunology, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag   +10 more
doaj   +1 more source

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Frontiers in Immunology, 2021
Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider, Mihály Józsi, Mihály Józsi   +7 more
doaj   +1 more source

Complement factor H related proteins (CFHRs)

Molecular Immunology, 2013
Factor H related proteins comprise a group of five plasma proteins: CFHR1, CFHR2, CFHR3, CFHR4 and CFHR5, and each member of this group binds to the central complement component C3b. Mutations, genetic deletions, duplications or rearrangements in the individual CFHR genes are associated with a number of diseases including atypical hemolytic uremic ...
Skerka, Christine, Chen, Qian, Fremeaux-Bacchi, Veronique, Roumenina, Lubka T.   +3 more
openaire   +2 more sources

Regulation of the Complement System by Pentraxins

Frontiers in Immunology, 2019
The functions of pentraxins, like C-reactive protein (CRP), serum amyloid protein P (SAP) and pentraxin-3 (PTX3), are to coordinate spatially and temporally targeted clearance of injured tissue components, to protect against infections and to regulate ...
Karita Haapasalo, Seppo Meri, Seppo Meri, Seppo Meri   +3 more
doaj   +1 more source

Novel circulating protein biomarkers for thyroid cancer determined through data-independent acquisition mass spectrometry [PDF]

PeerJ, 2020
Background Distinguishing between different types of thyroid cancers (TC) remains challenging in clinical laboratories. As different tumor types require different clinical interventions, it is necessary to establish new methods for accurate diagnosis of ...
Dandan Li, Jie Wu, Zhongjuan Liu, Ling Qiu, Yimin Zhang   +4 more
doaj   +2 more sources