Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4 [PDF]
Frontiers in Immunology, 2018 Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are hypothesized to act as antagonists of the important complement regulator factor H (FH), fine-tuning complement regulation on human
Richard B. Pouw +8 more
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Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration [PDF]
Journal of NeuroinflammationAge-related macular degeneration (AMD), a multifactorial type of retinal degeneration represents the most common cause for blindness in elderly. Polymorphisms in complement factor-H increase, while absence of factor-H-related protein-1 (FHR1) decreases ...
Andjela Sekulic +12 more
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Glomerular Complement Factor H–Related Protein 5 (FHR5) Is Highly Prevalent in C3 Glomerulopathy and Associated With Renal Impairment [PDF]
Kidney International Reports, 2019 Introduction: Therapeutic agents that target complement are increasingly available for glomerular diseases. However, the mechanisms linking glomerular complement deposition with inflammation and damage are incompletely understood.
Nicholas R. Medjeral-Thomas +6 more
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Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
Nature Communications, 2023 Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction.
Maria Jesus Iglesias +42 more
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Complement Factor H-Related Protein 3 Serum Levels Are Low Compared to Factor H and Mainly Determined by Gene Copy Number Variation in CFHR3. [PDF]
PLoS ONE, 2016 The major human complement regulator in blood, complement factor H (FH), has several closely related proteins, called FH-related (FHR) proteins. As all FHRs lack relevant complement regulatory activity, their physiological role is not well understood ...
Richard B Pouw +7 more
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Defining the Glycosaminoglycan Interactions of Complement Factor H-Related Protein 5. [PDF]
J Immunol, 2021 Abstract Complement activation is an important mediator of kidney injury in glomerulonephritis. Complement factor H (FH) and FH-related protein 5 (FHR-5) influence complement activation in C3 glomerulopathy and IgA nephropathy by differentially regulating glomerular complement.
Gyapon-Quast F +8 more
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Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy. [PDF]
J Am Soc Nephrol, 2022 Significance Statement Mutations in factor H–related protein 1 (FHR-1) that result in duplication of its dimerization domain associate with the chronic renal disease C3 glomerulopathy (C3G), which is characterized by complement dysregulation. The molecular basis for this association is only partially understood.
Márquez-Tirado B +15 more
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The Impact of Complement Factor H-Related Protein Gene Deletions on Kidney Transplantation. [PDF]
Scand J ImmunolABSTRACT We recently reported that a homozygous deletion in the complement factor H-related ( CFHR) locus predisposed kidney transplant patients to rejection. As donors carried intact genes, the susceptibility may have resulted from alloimmune reaction to FHR proteins.
Markkinen S +6 more
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins
Frontiers in Immunology, 2021 Inflammation is a common denominator of diseases. The complement system, an intrinsic part of the innate immune system, is a key driver of inflammation in numerous disorders.
Felix Poppelaars +11 more
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Recurrence of complement factor H-related protein 5 nephropathy in a renal transplant. [PDF]
Am J Transplant, 2011 Complement factor H-related protein 5 (CFHR5) nephropathy is a familial renal disease endemic in Cyprus. It is characterized by persistent microscopic hematuria, synpharyngitic macroscopic hematuria and progressive renal impairment. Isolated glomerular accumulation of complement component 3 (C3) is typical with variable degrees of glomerular ...
Vernon KA +9 more
europepmc +4 more sources