Kidney International Reports, 2021 Introduction: Immunoglobulin A nephrology (IgAN), characterized by co-deposition of IgA and complement components, is an activation of complement system involved disease.
Wei-yi Guo +6 more
doaj +1 more source
Factor H-Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation. [PDF]
, 2015 The physiological roles of the factor H (FH)-related proteins are controversial and poorly understood. Based on genetic studies, FH-related protein 5 (CFHR5) is implicated in glomerular diseases, such as atypical hemolytic uremic syndrome, dense deposit
Bánlaki, Zsófia +5 more
core +4 more sources
Novel circulating protein biomarkers for thyroid cancer determined through data-independent acquisition mass spectrometry [PDF]
PeerJ, 2020 Background Distinguishing between different types of thyroid cancers (TC) remains challenging in clinical laboratories. As different tumor types require different clinical interventions, it is necessary to establish new methods for accurate diagnosis of ...
Dandan Li +4 more
doaj +2 more sources
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein [PDF]
, 2012 Human complement factor H-related protein (CFHR) 4 belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains.
Hebecker, Mario, Józsi, Mihály
core +1 more source
Regulation of the Complement System by Pentraxins
Frontiers in Immunology, 2019 The functions of pentraxins, like C-reactive protein (CRP), serum amyloid protein P (SAP) and pentraxin-3 (PTX3), are to coordinate spatially and temporally targeted clearance of injured tissue components, to protect against infections and to regulate ...
Karita Haapasalo +3 more
doaj +1 more source
Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease
Scientific Reports, 2021 Atherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellular necrosis ...
Sarah Irmscher +23 more
doaj +1 more source
Zinc-induced self-association of complement C3b and Factor H: implications for inflammation and age-related macular degeneration. [PDF]
, 2013 The sub-retinal pigment epithelial deposits (sRPEds) that are a hallmark of age-related macular degeneration (AMD) contain both C3b and mM levels of zinc.
Gor, J +6 more
core +1 more source
The Murine Factor H-Related Protein FHR-B Promotes Complement Activation
Frontiers in Immunology, 2017 Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp +16 more
doaj +1 more source
Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]
, 2012 Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Hammerschmidt, Claudia +6 more
core +3 more sources