Results 31 to 40 of about 1,169,724 (211)

FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation [PDF]

, 2017
Factor H (FH)-related protein 1 (FHR-1) is one of the five human factor H-related proteins, which share sequence and structural homology with the alternative pathway complement inhibitor FH.
Bánlaki, Zsófia, Cserhalmi, Marcell, Csincsi, Ádám, Józsi, Mihály, Kárpáti, Éva, Prohászka, Zoltán, Szabó, Z., Uzonyi, Barbara   +7 more
core   +1 more source

NF-κB-dependent increase in tissue factor expression is responsible for hypoxic podocyte injury [PDF]

, 2015
BACKGROUND: Fibrin deposition within glomeruli is commonly seen in kidney biopsy specimens, suggesting enhanced coagulant activity. Tissue factor (TF) is a coagulation factor which is also related to various biological effects, and TF is upregulated by ...
Kawai, Misato, Kinjo, Takahiko, Mathieson, Peter W, Murakami, Reiichi, Nakamura, Masayuki, Nakamura, Norio, Narita, Ikuyo, Nishizaki, Kimitaka, Okumura, Ken, Saleem, Moin A, Shimada, Michiko, Tanno, Tomohiro, Tomita, Hirofumi, Yamabe, Hideaki   +13 more
core   +2 more sources

Factor H-related protein 1 in systemic lupus erythematosus

Frontiers in Immunology
BackgroundFactor H (FH) is a major soluble inhibitor of the complement system and part of a family comprising five related proteins (FHRs 1–5). Deficiency of FHR1 was described to be linked to an elevated risk of systemic lupus erythematosus (SLE).
Jessica S. Kleer, Jessica S. Kleer, Juliane Klehr, Denise Dubler, Laura Infanti, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg, Marten Trendelenburg   +9 more
doaj   +1 more source

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R, Fu, Yingjie, Huang, Lei, Li, Yong, Ma, Qingyi, Song, Minwoo A, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +8 more
core   +2 more sources

A new perspective on AMD pathogenesis: a sequential Factor H-centered view of complement dysregulation

Frontiers in Immunology
Age-related macular degeneration (AMD) is a chronic, progressive, retinal disease that primarily affects older individuals and is one of the leading causes of blindness worldwide.
Christine Skerka, Björn Cochlovius, Judith P. Hüllebrand, Deepti Goel, Purnima Sood, Nikhil Pal, Arindam Chakravarti, Daniel R. Muth, Daniel R. Muth, Daniel R. Muth, Daniel R. Muth, Oliver Zeitz, Peter F. Zipfel   +12 more
doaj   +1 more source

Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration

Nature Communications, 2020
A locus on chromosome 1 encompassing the CFHR genes is highly associated with AMD risk. Here, Cipriani and colleagues investigate the role of CFHR4, encoding FHR-4, and demonstrate a relationship between AMD risk, circulating FHR-4 levels and genetic ...
Valentina Cipriani, Laura Lorés-Motta, Fan He, Dina Fathalla, Viranga Tilakaratna, Selina McHarg, Nadhim Bayatti, İlhan E. Acar, Carel B. Hoyng, Sascha Fauser, Anthony T. Moore, John R. W. Yates, Eiko K. de Jong, B. Paul Morgan, Anneke I. den Hollander, Paul N. Bishop, Simon J. Clark   +16 more
doaj   +1 more source

Identification of CFHR4 associated with poor prognosis of hepatocellular carcinoma

Frontiers in Oncology, 2022
BackgroundHepatocellular carcinoma (HCC) is one of the most leading causes of cancer death worldwide. The 5-year survival rate of HCC patients remains low due to the lack of early-stage symptoms.
Qinglin Ding, Hanluo Li, Zhigao Xu, Kanghong Hu, Qifa Ye   +4 more
doaj   +1 more source

Complement Factor H and Related Proteins as Markers of Cardiovascular Risk in Pediatric Chronic Kidney Disease

Biomedicines, 2022
Cardiovascular disease (CVD) is the main cause of mortality among chronic kidney disease (CKD) patients, both in adults and in children. Hypertension is one of the risk factors of CVD.
Wei-Ting Liao, Wei-Ling Chen, You-Lin Tain, Chien-Ning Hsu   +3 more
doaj   +1 more source

Induction of heme oxygenase-1 by hemin protects lung against orthotopic autologous liver transplantation-induced acute lung injury in rats [PDF]

, 2016
BACKGROUND: Post-liver transplantation acute lung injury (ALI) severely affects patients’ survival, whereas the mechanism is unclear and effective therapy is lacking.
Jun Cai, Na Guo, Wanling Gao, Weifeng Yao, Xinjin Chi, Yi Jin, Ziqing Hei   +6 more
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source