Results 31 to 40 of about 1,814,273 (138)

Dual Role of Factor H-Related Protein 1 in IgA Nephropathy Kidney Injury. [PDF]

Kidney Int Rep
IgA nephropathy (IgAN) is characterized by glomerular IgA deposition, inducing complement activation and inflammation. Previous investigations have highlighted the association of factor H (FH)-related protein 1 (FHR-1) with IgAN. Given the dual functionality of FHR-1, encompassing its "canonical function" in complement activation and "noncanonical ...
Kang Y, Li X, Yuan X, Shi S, Lv J, Zhu L, Zhang H.   +6 more
europepmc   +3 more sources

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation

Frontiers in Immunology, 2022
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Zoltán Prohászka, Anna Erdei, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi, Mihály Józsi   +16 more
doaj   +1 more source

Factor H‐related protein 1: a complement regulatory protein and guardian of necrotic‐type surfaces [PDF]

British Journal of Pharmacology, 2020
Factor H‐related protein 1 (FHR‐1) is a member of the factor H protein family, which is involved in regulating innate immune complement reactions. Genetic modification of the encoding gene, CFHR1 on human chromosome 1, is involved in diseases such as age‐related macular degeneration, C3 glomerulopathy and atypical haemolytic uraemic syndrome ...
Skerka, Christine, Pradel, Gabriele, Halder, Luke D., Zipfel, Peter F., Zipfel, Svante L. H., Strauß, Olaf   +5 more
openaire   +3 more sources

High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B

Frontiers in Immunology, 2018
Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a poor ...
Richard B. Pouw, Richard B. Pouw, Irene Gómez Delgado, Alberto López Lera, Santiago Rodríguez de Córdoba, Diana Wouters, Taco W. Kuijpers, Taco W. Kuijpers, Pilar Sánchez-Corral   +8 more
doaj   +1 more source

Regulation of regulators: Role of the complement factor H-related proteins

Seminars in Immunology, 2019
The complement system, while being an essential and very efficient effector component of innate immunity, may cause damage to the host and result in various inflammatory, autoimmune and infectious diseases or cancer, when it is improperly activated or regulated.
Cserhalmi, Marcell, Papp, A., Brandus, B., Uzonyi, Barbara, Józsi, Mihály   +4 more
openaire   +4 more sources

Dimerization of complement factor H-related proteins modulates complement activation in vivo [PDF]

Proceedings of the National Academy of Sciences, 2013
The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related ( CFHR ) locus.
Goicoechea de Jorge, E, Caesar, J, Malik, T, Patel, M, Colledge, M, Johnson, S, Hakobyan, S, Morgan, B, Harris, C, Pickering, M, Lea, S   +10 more
openaire   +4 more sources

Catastrophic antiphospholipid syndrome accompanied by complement regulatory gene mutation

The Turkish Journal of Pediatrics, 2023
Background. Antiphospholipid syndrome (APS), particularly the catastrophic antiphospholipid syndrome (CAPS), is one of the rare causes of thrombotic microangiopathy (TMA).
Serim Pul, Betül Sözeri, Cemile Pehlivanoğlu, Deniz Filinte, Özde Nisa Türkkan, Mehtap Sak, Neslihan Çiçek, Serçin Güven, Ece Demirci Bodur, İbrahim Gökçe, Harika Alpay   +10 more
doaj   +1 more source

Hypoglycemia-induced changes in complement pathways in type 2 diabetes

Atherosclerosis Plus, 2021
Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothesized
Abu Saleh Md Moin, Manjula Nandakumar, Ilhame Diboun, Ahmed Al-Qaissi, Thozhukat Sathyapalan, Stephen L. Atkin, Alexandra E. Butler   +6 more
doaj   +1 more source

A new perspective on AMD pathogenesis: a sequential Factor H-centered view of complement dysregulation

Frontiers in Immunology
Age-related macular degeneration (AMD) is a chronic, progressive, retinal disease that primarily affects older individuals and is one of the leading causes of blindness worldwide.
Christine Skerka, Björn Cochlovius, Judith P. Hüllebrand, Deepti Goel, Purnima Sood, Nikhil Pal, Arindam Chakravarti, Daniel R. Muth, Daniel R. Muth, Daniel R. Muth, Daniel R. Muth, Oliver Zeitz, Peter F. Zipfel   +12 more
doaj   +1 more source

Complement Factor H and Related Proteins as Markers of Cardiovascular Risk in Pediatric Chronic Kidney Disease

Biomedicines, 2022
Cardiovascular disease (CVD) is the main cause of mortality among chronic kidney disease (CKD) patients, both in adults and in children. Hypertension is one of the risk factors of CVD.
Wei-Ting Liao, Wei-Ling Chen, You-Lin Tain, Chien-Ning Hsu   +3 more
doaj   +1 more source