Results 41 to 50 of about 1,814,273 (138)

Identification of CFHR4 associated with poor prognosis of hepatocellular carcinoma

Frontiers in Oncology, 2022
BackgroundHepatocellular carcinoma (HCC) is one of the most leading causes of cancer death worldwide. The 5-year survival rate of HCC patients remains low due to the lack of early-stage symptoms.
Qinglin Ding, Hanluo Li, Zhigao Xu, Kanghong Hu, Qifa Ye   +4 more
doaj   +1 more source

Complement factor H–related hybrid protein deregulates complement in dense deposit disease [PDF]

Journal of Clinical Investigation, 2013
The renal disorder C3 glomerulopathy with dense deposit disease (C3G-DDD) pattern results from complement dysfunction and primarily affects children and young adults. There is no effective treatment, and patients often progress to end-stage renal failure.
Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF   +11 more
openaire   +3 more sources

Mechanisms by which Factor H protects Trypanosoma cruzi from the alternative pathway of complement

Frontiers in Immunology
Chagas disease, a chronic disabling disease caused by the protozoan Trypanosoma cruzi, has no standardized treatment or preventative vaccine. The infective trypomastigote form of T.
Smrithi S. Menon, Galia Ramirez-Toloza, Keith L. Wycoff, Sean Ehinger, Jutamas Shaughnessy, Sanjay Ram, Viviana P. Ferreira   +6 more
doaj   +1 more source

FACI Is a Novel CREB-H–Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced ObesitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: CREB-H is a key liver-enriched transcription factor governing lipid metabolism. Additional targets of CREB-H remain to be identified and characterized.
Yun Cheng, Xiao-Zhuo Kang, Tao Cheng, Zi-Wei Ye, George L. Tipoe, Cheng-Han Yu, Chi-Ming Wong, Baohua Liu, Chi-Ping Chan, Dong-Yan Jin   +9 more
doaj   +1 more source

Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD. [PDF]

Eur J Immunol
ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world, with a predicted 288 million individuals affected worldwide by the year 2040. Both genetic and biochemical evidence point toward complement overactivation, through a diminished regulatory capacity, at the back of the eye ...
Tang J, Zgoda N, Clark SJ.
europepmc   +2 more sources

FHR-5 Serum Levels and CFHR5 Genetic Variations in Patients With Immune Complex-Mediated Membranoproliferative Glomerulonephritis and C3-Glomerulopathy

Frontiers in Immunology, 2021
BackgroundFactor H-related protein 5 (FHR-5) is a member of the complement Factor H protein family. Due to the homology to Factor H, the main complement regulator of the alternative pathway, it may also be implicated in the pathomechanism of kidney ...
Nóra Garam, Marcell Cserhalmi, Zoltán Prohászka, Zoltán Prohászka, Ágnes Szilágyi, Nóra Veszeli, Nóra Veszeli, Edina Szabó, Barbara Uzonyi, Attila Iliás, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder-Plassmann, Dóra Bajcsi, Jürgen Brunner, Alexandra Dumfarth, Daniel Cejka, Stefan Flaschberger, Hana Flögelova, Ágnes Haris, Ágnes Hartmann, Andreas Heilos, Thomas Mueller, Krisztina Rusai, Klaus Arbeiter, Johannes Hofer, Johannes Hofer, Johannes Hofer, Dániel Jakab, Mária Sinkó, Erika Szigeti, Csaba Bereczki, Viktor Janko, Kata Kelen, György S. Reusz, Attila J. Szabó, Nóra Klenk, Krisztina Kóbor, Nika Kojc, Maarten Knechtelsdorfer, Mario Laganovic, Adrian Catalin Lungu, Anamarija Meglic, Rina Rus, Tanja Kersnik Levart, Ernesta Macioniene, Marius Miglinas, Anna Pawłowska, Tomasz Stompór, Ludmila Podracka, Michael Rudnicki, Gert Mayer, Romana Rysava, Jana Reiterova, Marijan Saraga, Marijan Saraga, Tomáš Seeman, Jakub Zieg, Eva Sládková, Natasa Stajic, Tamás Szabó, Andrei Capitanescu, Simona Stancu, Miroslav Tisljar, Kresimir Galesic, András Tislér, Inga Vainumäe, Martin Windpessl, Tomas Zaoral, Galia Zlatanova, Mihály Józsi, Mihály Józsi, Dorottya Csuka, Dorottya Csuka   +74 more
doaj   +1 more source

Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. [PDF]

PLoS Genetics, 2007
Atypical hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. Disease-associated mutations have been described in the genes encoding the complement regulators complement factor H, membrane cofactor protein, factor B, and ...
Peter F Zipfel, Matthew Edey, Stefan Heinen, Mihály Józsi, Heiko Richter, Joachim Misselwitz, Bernd Hoppe, Danny Routledge, Lisa Strain, Anne E Hughes, Judith A Goodship, Christoph Licht, Timothy H J Goodship, Christine Skerka   +13 more
doaj   +1 more source

Complement-Independent Modulation of Influenza A Virus Infection by Factor H

Frontiers in Immunology, 2020
The complement system is an ancient innate immune defense mechanism that can recognize molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface ...
Valarmathy Murugaiah, Praveen M. Varghese, Praveen M. Varghese, Soad M. Saleh, Anthony G. Tsolaki, Salman H. Alrokayan, Haseeb A. Khan, Kate S. Collison, Robert B. Sim, Béatrice Nal, Futwan A. Al-Mohanna, Uday Kishore   +11 more
doaj   +1 more source

The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.

PLoS Pathogens, 2008
The Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum.
Katrin Haupt, Michael Reuter, Jean van den Elsen, Julia Burman, Steffi Hälbich, Julia Richter, Christine Skerka, Peter F Zipfel   +7 more
doaj   +1 more source

Lipoxin A4-induced heme oxygenase-1 protects cardiomyocytes against hypoxia/reoxygenation injury via p38 MAPK activation and Nrf2/ARE complex. [PDF]

PLoS ONE, 2013
To investigate whether lipoxin A4 (LXA4) increases expression of heme oxygenase-1(HO-1) in cardiomyocytes, whether LXA4-induced HO-1 protects cardiomyocytes against hypoxia/reoxygenation (H/R) injury, and what are the mechanisms involved in the LXA4 ...
Xiao-Qing Chen, Sheng-Hua Wu, Yu Zhou, Yan-Rong Tang   +3 more
doaj   +1 more source