Results 21 to 30 of about 1,404,145 (255)

Properdin and factor H: Opposing players on the alternative complement pathway "see-saw" [PDF]

, 2013
This article has been made available through the Brunel Open Access Publishing Fund.Properdin and factor H are two key regulatory proteins having opposite functions in the alternative complement pathway.
Kouser, L, Cordula M. Stover, Munirah Abdul-Aziz, Robert B. Sim, Nayak, A, Lubna Kouser, L. Kouser (7639589), Kishore, U, M. Abdul-Aziz (7677725), R. B. Sim (7584038), U. Kishore (7639601), Cordula M. Stover (7117046), Abdul-Aziz, M, Annapurna Nayak, A. Nayak (7334981), Stover, CM, Sim, RB, Uday Kishore   +17 more
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CLONING OF THE 1.4-kb mRNA SPECIES OF HUMAN COMPLEMENT FACTOR H REVEALS A NOVEL MEMBER OF THE SHORT CONSENSUS REPEAT FAMILY RELATED TO THE CARBOXY TERMINAL OF THE CLASSICAL 150-kDa MOLECULE [PDF]

, 1991
Three factor H mRNA species of 4.3 kb, 1.8 kb, and 1.4 kb are constitutively expressed in human liver. Having previously characterized full-length cDNA clones derived from the 4.3-kb and 1.8-kb factor mRNA, we report here the isolation and eucaryotic ...
Estaller, C., Schwaeble, W., Koistinen, V., Dierich, Manfred P., Weiss, Elisabeth H.   +4 more
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Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma

Frontiers in Immunology, 2017
The complement factor H-related (FHR) proteins are hypothesized to fine-tune the regulatory role of complement factor H (FH) in the alternative pathway of the complement system.
Anna E. van Beek, Anna E. van Beek, Richard B. Pouw, Richard B. Pouw, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Pleuni Ooijevaar-de Heer, Martin de Boer, Karin van Leeuwen, Theo Rispens, Diana Wouters, Taco W. Kuijpers, Taco W. Kuijpers   +13 more
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Factor H-related proteins determine complement-activating surfaces. [PDF]

, 2015
Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation.
Tortajada, A., Barbara Uzonyi, Agustin Tortajada, Rodriguez de Cordoba, S., Mihály Józsi, Rodriguez de Cordoba, Santiago, Goicoechea De Jorge, Elena, Mihaly, Jozsi, Tortajada Alonso, Agustín, Santiago Rodríguez de Córdoba, Józsi, Mihály, Elena Goicoechea de Jorge, Goicoechea de, Jorge E., Uzonyi, Barbara   +13 more
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Maternal liver damage induced by cadmium exposure in pregnant mice through hypoxia inducible factor-1α-mediated upregulation in DRP1

环境与职业医学, 2023
BackgroundMitochondrial dynamin-related protein 1 (DRP1) regulates mitochondrial division and plays an important role in maintaining hepatocyte function. However, the role of DRP1 in cadmium exposure-induced maternal liver damage in pregnant mice remains
Limin DAI, Hualong ZHU, Yongwei XIONG, Weibo LIU, Guoxiang ZHOU, Shuang ZHANG, Zhengjia LING, Lulu TAN, Jin ZHANG, Yufeng ZHANG, Yiting FU, Daixin LI, Hua WANG   +12 more
doaj   +1 more source

Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi [PDF]

, 2012
Borrelia burgdorferi evades complement-mediated killing by interacting with complement regulators through distinct complement regulator-acquiring surface proteins (CRASPs).
Teresia Hallström, Peter F. Zipfel, Zipfel, Peter F, Christine Skerka, Hallström, Teresia, Kraiczy, Peter, Skerka, Christine, Claudia Hammerschmidt, Wallich, Reinhard, Hammerschmidt, Claudia, Zipfel, Peter F., Reinhard Wallich, Peter Kraiczy, Stevenson, Brian, Brian Stevenson   +14 more
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CFH and CFHR Copy Number Variations in C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Frontiers in Genetics, 2021
C3 Glomerulopathy (C3G) and Immune Complex-Mediated Membranoproliferative glomerulonephritis (IC-MPGN) are rare diseases characterized by glomerular deposition of C3 caused by dysregulation of the alternative pathway (AP) of complement.
Rossella Piras, Matteo Breno, Elisabetta Valoti, Marta Alberti, Paraskevas Iatropoulos, Caterina Mele, Elena Bresin, Roberta Donadelli, Paola Cuccarolo, Richard J. H. Smith, Ariela Benigni, Giuseppe Remuzzi, Marina Noris   +12 more
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Mechanism of Borrelia immune evasion by FhbA-related proteins.

PLoS Pathogens, 2022
Immune evasion facilitates survival of Borrelia, leading to infections like relapsing fever and Lyme disease. Important mechanism for complement evasion is acquisition of the main host complement inhibitor, factor H (FH). By determining the 2.2 Å crystal
Konstantin Kogan, Karita Haapasalo, Tommi Kotila, Robin Moore, Pekka Lappalainen, Adrian Goldman, Taru Meri   +6 more
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Blood-based protein biomarkers for the diagnosis of acute stroke: A discovery-based SWATH-MS proteomic approach

Frontiers in Neurology, 2022
Background and purposesRecent developments in high-throughput proteomic approach have shown the potential to discover biomarkers for diagnosing acute stroke and to elucidate the pathomechanisms specific to different stroke subtypes. We aimed to determine
Shubham Misra, Praveen Singh, Manabesh Nath, Divya Bhalla, Shantanu Sengupta, Amit Kumar, Awadh K. Pandit, Praveen Aggarwal, Achal K. Srivastava, Dheeraj Mohania, Kameshwar Prasad, Kameshwar Prasad, Deepti Vibha   +12 more
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Evaluating the clinical utility of measuring levels of factor H and the related proteins [PDF]

, 2022
After years of disappointing clinical results, the tide has finally changed and complement targeted-therapies have become a validated and accepted treatment option for several diseases. These accomplishments have revitalized the field and brought renewed
Pouw, Richard B., SciFiMed Consortium, Banerjee, Pratiti, Veuskens, Bert R.J., Pouw, Richard B, Baeumner, Antje J., Baeumner, Antje J, Toonen, Erik J M, de Jorge, Elena Goicoechea, Toonen, Erik J.M., Pauly, Diana, Veuskens, Bert, Poppelaars, Felix, Steiner, Mark-Steven, Steiner, Mark Steven, Józsi, Mihály   +15 more
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