Results 21 to 30 of about 1,408,273 (290)
Factor H-related protein 1 in systemic lupus erythematosus [PDF]
Frontiers in ImmunologyBackgroundFactor H (FH) is a major soluble inhibitor of the complement system and part of a family comprising five related proteins (FHRs 1–5). Deficiency of FHR1 was described to be linked to an elevated risk of systemic lupus erythematosus (SLE).
Jessica S. Kleer +9 more
doaj +3 more sources
Human factor H-related protein 2 (CFHR2) regulates complement activation. [PDF]
PLoS ONE, 2013 Mutations and deletions within the human CFHR gene cluster on chromosome 1 are associated with diseases, such as dense deposit disease, CFHR nephropathy or age-related macular degeneration. Resulting mutant CFHR proteins can affect complement regulation.
Hannes U Eberhardt +10 more
doaj +4 more sources
Role of factor H-related protein 3 in Pseudomonas aeruginosa bloodstream infections
Frontiers in ImmunologyPseudomonas aeruginosa is a leading cause of nosocomial bloodstream infections. The outcome of these infections depends on the virulence of the microorganism as well as host-related conditions and factors.
Alex González-Alsina +7 more
doaj +5 more sources
Factor H-related protein 1 promotes complement-mediated opsonization of Pseudomonas aeruginosa
Frontiers in Cellular and Infection MicrobiologyPseudomonas aeruginosa is an important human opportunistic pathogen responsible for a wide range of infections. The complement system is the main early host defense mechanism to control these infections. P.
Alex González-Alsina +7 more
doaj +4 more sources
Defining the Glycosaminoglycan Interactions of Complement Factor H–Related Protein 5 [PDF]
The Journal of Immunology, 2021 Abstract Complement activation is an important mediator of kidney injury in glomerulonephritis. Complement factor H (FH) and FH-related protein 5 (FHR-5) influence complement activation in C3 glomerulopathy and IgA nephropathy by differentially regulating glomerular complement.
Frederick Gyapon-Quast +8 more
openaire +4 more sources
Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces [PDF]
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remove the complement regulator FH from surfaces that strongly fix opsonic C3b molecules—a process known as “
Arthur Dopler +10 more
openaire +3 more sources
Biomedicines, 2022 Cardiovascular disease (CVD) is the main cause of mortality among chronic kidney disease (CKD) patients, both in adults and in children. Hypertension is one of the risk factors of CVD.
Wei-Ting Liao +3 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare disease that manifests with microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure, and is associated with dysregulation of the alternative complement pathway.
Rossella Piras +11 more
doaj +1 more source
Hypoglycemia-induced changes in complement pathways in type 2 diabetes
Atherosclerosis Plus, 2021 Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothesized
Abu Saleh Md Moin +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Atypical hemolytic–uremic syndrome (aHUS) is a severe thrombotic microangiopathy in which kidney involvement is common. aHUS can be due to either genetic or acquired abnormalities, with most abnormalities affecting the alternative complement pathway ...
Emma Diletta Stea +11 more
doaj +1 more source