Results 21 to 30 of about 26,183,286 (282)

Factor H-related protein 1 in systemic lupus erythematosus [PDF]

Frontiers in Immunology
BackgroundFactor H (FH) is a major soluble inhibitor of the complement system and part of a family comprising five related proteins (FHRs 1–5). Deficiency of FHR1 was described to be linked to an elevated risk of systemic lupus erythematosus (SLE).
Jessica S. Kleer, Jessica S. Kleer, Juliane Klehr, Denise Dubler, Laura Infanti, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg, Marten Trendelenburg   +9 more
doaj   +3 more sources

Polymorphism and deficiency of human factor H-related proteins p39 and p37

Immunogenetics, 1992
We described previously cDNA clones representing a novel factor H-related 1.4 kilobase mRNA. This mRNA species codes for a doublet of serum proteins of M(r) 39 000 and 37 000 (p39/p37).
W. Schwaeble, Roberta Misasi, D. Schonitzer, M. Molgg, Wolfgangm Prodinger, Vesa Koistinen, Martin M�lgg, ManfredP. Dierich, MISASI, Roberta, Dieter Sch�nitzer, Manfredp Dierich, WolfgangM. Prodinger, Wilhelm Schweble, Elisabeth Feifel   +13 more
core   +4 more sources

Role of factor H-related protein 3 in Pseudomonas aeruginosa bloodstream infections

Frontiers in Immunology
Pseudomonas aeruginosa is a leading cause of nosocomial bloodstream infections. The outcome of these infections depends on the virulence of the microorganism as well as host-related conditions and factors.
Alex González-Alsina, Héctor Martín-Merinero, Margalida Mateu-Borrás, María Verd, Antonio Doménech-Sánchez, Joanna B. Goldberg, Santiago Rodríguez de Córdoba, Sebastián Albertí   +7 more
doaj   +5 more sources

Factor H-related protein 1 promotes complement-mediated opsonization of Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology
Pseudomonas aeruginosa is an important human opportunistic pathogen responsible for a wide range of infections. The complement system is the main early host defense mechanism to control these infections. P.
Alex González-Alsina, Héctor Martín-Merinero, Margalida Mateu-Borrás, María Verd, Antonio Doménech-Sánchez, Joanna B. Goldberg, Santiago Rodríguez de Córdoba, Sebastián Albertí   +7 more
doaj   +4 more sources

Defining the Glycosaminoglycan Interactions of Complement Factor H–Related Protein 5 [PDF]

The Journal of Immunology, 2021
Abstract Complement activation is an important mediator of kidney injury in glomerulonephritis. Complement factor H (FH) and FH-related protein 5 (FHR-5) influence complement activation in C3 glomerulopathy and IgA nephropathy by differentially regulating glomerular complement.
Frederick Gyapon-Quast, Elena Goicoechea de Jorge, Talat Malik, Nian Wu, Jin Yu, Wengang Chai, Ten Feizi, Yan Liu, Matthew C Pickering   +8 more
openaire   +4 more sources

The Factor H protein family: The switchers of the complement alternative pathway [PDF]

, 2022
CRUE-CSIC (Acuerdos Transformativos 2022)The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including ...
Márquez Tirado, Bárbara, Lucientes Continente, Laura, Márquez-Tirado, Bárbara, Goicoechea de Jorge, Elena, Bárbara Márquez‐Tirado, Lucientes-Continente, Laura, Laura Lucientes‐Continente, Elena Goicoechea de Jorge   +7 more
core   +1 more source

Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces [PDF]

Frontiers in Immunology, 2021
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remove the complement regulator FH from surfaces that strongly fix opsonic C3b molecules—a process known as “
Arthur Dopler, Selina Stibitzky, Rachel Hevey, Marco Mannes, Mara Guariento, Britta Höchsmann, Britta Höchsmann, Hubert Schrezenmeier, Hubert Schrezenmeier, Daniel Ricklin, Christoph Q. Schmidt   +10 more
openaire   +3 more sources

Contribución de variantes funcionales y cuantitativas del Factor H y las proteínas FHRs (Factor H-Related proteins) del Complemento en patología renal

Nefrología, 2022
Resumen: El sistema del Complemento protege al organismo frente a procesos infecciosos, tumorales y autoinmunes, y requiere una regulación muy estricta para evitar una activación excesiva o inespecífica.
Irene Gómez Delgado, Pilar Sánchez-Corral   +1 more
doaj   +1 more source

Decoding the Factor H-Related Proteins: Gatekeepers of Complement Dysregulation in AMD. [PDF]

Eur J Immunol
ABSTRACT Age‐related macular degeneration (AMD) is the third most common form of blindness in the Western world, with a predicted 288 million individuals affected worldwide by the year 2040. Both genetic and biochemical evidence point toward complement overactivation, through a diminished regulatory capacity, at the back of the eye ...
Tang J, Zgoda N, Clark SJ.
europepmc   +2 more sources

Beyond factor H:The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations [PDF]

, 2021
Age-related macular degeneration (AMD) is a leading cause of vision loss; there is strong genetic susceptibility at the complement factor H (CFH) locus. This locus encodes a series of complement regulators: factor H (FH), a splice variant factor-H-like 1
Clark, Simon J, Clark, Simon J; id_orcid, Tierney, Anna, Griffiths, John R, Cipriani, Valentina, Moore, Anthony T, Sergouniotis, Panagiotis, Unwin, Richard D; id_orcid, Yates, John RW, Sergouniotis, Panagiotis I, Bishop, Paul N, Yates, John R W, Unwin, Richard D, Zuber, Verena, Sergouniotis, Panagiotis I; id_orcid, Panagiotis I. Sergouniotis, John R.W. Yates, John R. Griffiths, Paul N. Bishop, Anthony T. Moore, Richard D. Unwin, Valentina Cipriani, Verena Zuber, Simon J. Clark, Anna Tierney   +24 more
core   +1 more source