Results 11 to 20 of about 2,205,533 (300)

Reference Intervals of Factor H and Factor H-Related Proteins in Healthy Children [PDF]

Frontiers in Immunology, 2018
Complement is activated as part of the innate immune defense against invading pathogens. Also, it helps to remove apoptotic debris and immune complexes from the circulation.
Anna E. van Beek, Anna E. van Beek, Angela Kamp, Simone Kruithof, Ed J. Nieuwenhuys, Diana Wouters, Ilse Jongerius, Theo Rispens, Taco W. Kuijpers, Taco W. Kuijpers, Kyra A. Gelderman   +10 more
doaj   +6 more sources

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies [PDF]

Frontiers in Immunology, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag   +10 more
doaj   +2 more sources

Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation [PDF]

Frontiers in Immunology, 2022
Components of the extracellular matrix (ECM), when exposed to body fluids may promote local complement activation and inflammation. Pathologic complement activation at the glomerular basement membrane and at the Bruch’s membrane is implicated in renal ...
Alexandra Papp, Krisztián Papp, Barbara Uzonyi, Barbara Uzonyi, Marcell Cserhalmi, Ádám I. Csincsi, Zsóka Szabó, Zsófia Bánlaki, David Ermert, Zoltán Prohászka, Zoltán Prohászka, Anna Erdei, Anna Erdei, Viviana P. Ferreira, Anna M. Blom, Mihály Józsi, Mihály Józsi   +16 more
doaj   +2 more sources

Identification of novel blood-borne soluble binding partners of factor H-related proteins [PDF]

Scientific Reports
The deposition of circulating complement factor H-related (FHR) proteins in tissues around the body has been implicated in a series of complement-mediated diseases.
Jiaqi Tang, Franziska Woerz, Tina Beyer, Karsten Boldt, Sonika Rathi, Shiying Zhao, Lasse Wolfram, Marius Ueffing, Simon J. Clark   +8 more
doaj   +2 more sources

Factor H-related proteins determine complement-activating surfaces [PDF]

Trends in Immunology, 2015
Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation. Because FHRs are evolutionarily and structurally related to complement inhibitor factor H (FH), the initial assumption was that the FHRs are also
Józsi, Mihály, Tortajada, A., Uzonyi, Barbara, Goicoechea de, Jorge E., Rodriguez de Cordoba, S.   +4 more
openaire   +6 more sources

Development and Characterization of Novel ELISAs for the Specific Quantification of the Factor H-Related Proteins 2, 3, 4, and 5 [PDF]

Journal of Innate Immunity
Introduction: The complement system’s alternative pathway relies on factor H (FH) for immune homeostasis. Next to FH, a group of highly similar proteins was described known as the FH-related (FHR) proteins.
Mara van Rossum, Bert R.J. Veuskens, Mieke C. Brouwer, Gerard van Mierlo, Laura Lucientes-Continente, Elena Goicoechea de Jorge, Barbara Uzonyi, Alexandra T. Matola, Mihály Józsi, Günter Müller, Anita M. Meter-Arkema, Felix Poppelaars, Diana Pauly, Richard B. Pouw, Erik J.M. Toonen   +14 more
doaj   +2 more sources

Human factor H-related protein 2 (CFHR2) regulates complement activation. [PDF]

PLoS ONE, 2013
Mutations and deletions within the human CFHR gene cluster on chromosome 1 are associated with diseases, such as dense deposit disease, CFHR nephropathy or age-related macular degeneration. Resulting mutant CFHR proteins can affect complement regulation.
Hannes U Eberhardt, Denise Buhlmann, Peter Hortschansky, Qian Chen, Sascha Böhm, Markus J Kemper, Reinhard Wallich, Andrea Hartmann, Teresia Hallström, Peter F Zipfel, Christine Skerka   +10 more
doaj   +4 more sources

Factor H-related protein 1 in systemic lupus erythematosus [PDF]

Frontiers in Immunology
BackgroundFactor H (FH) is a major soluble inhibitor of the complement system and part of a family comprising five related proteins (FHRs 1–5). Deficiency of FHR1 was described to be linked to an elevated risk of systemic lupus erythematosus (SLE).
Jessica S. Kleer, Jessica S. Kleer, Juliane Klehr, Denise Dubler, Laura Infanti, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg, Marten Trendelenburg   +9 more
doaj   +3 more sources

Factor H related proteins modulate complement activation on kidney cells. [PDF]

Kidney Int, 2022
Complement activation at a particular location is determined by the balance of activating and inhibitory proteins. Factor H is a key regulator of the alternative pathway of complement, and genetic or acquired impairments in Factor H are associated with glomerular injury. The human Factor H-related proteins (FHRs) comprise a family of five proteins that
Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM.   +12 more
europepmc   +4 more sources

Role of factor H-related protein 3 in Pseudomonas aeruginosa bloodstream infections

Frontiers in Immunology
Pseudomonas aeruginosa is a leading cause of nosocomial bloodstream infections. The outcome of these infections depends on the virulence of the microorganism as well as host-related conditions and factors.
Alex González-Alsina, Héctor Martín-Merinero, Margalida Mateu-Borrás, María Verd, Antonio Doménech-Sánchez, Joanna B. Goldberg, Santiago Rodríguez de Córdoba, Sebastián Albertí   +7 more
doaj   +4 more sources