Results 11 to 20 of about 1,408,273 (290)

Factor H related proteins modulate complement activation on kidney cells. [PDF]

Kidney Int, 2022
Complement activation at a particular location is determined by the balance of activating and inhibitory proteins. Factor H is a key regulator of the alternative pathway of complement, and genetic or acquired impairments in Factor H are associated with glomerular injury. The human Factor H-related proteins (FHRs) comprise a family of five proteins that
Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM.   +12 more
europepmc   +7 more sources

Dimerization of complement factor H-related proteins modulates complement activation in vivo. [PDF]

Proc Natl Acad Sci U S A, 2013
The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related ( CFHR ) locus. Elucidating the mechanism underlying these associations has been hindered
Goicoechea de Jorge E, Caesar JJ, Malik TH, Patel M, Colledge M, Johnson S, Hakobyan S, Morgan BP, Harris CL, Pickering MC, Lea SM.   +10 more
europepmc   +10 more sources

Factor H-related proteins determine complement-activating surfaces [PDF]

Trends in Immunology, 2015
Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation. Because FHRs are evolutionarily and structurally related to complement inhibitor factor H (FH), the initial assumption was that the FHRs are also
Józsi, Mihály, Tortajada, A., Uzonyi, Barbara, Goicoechea de, Jorge E., Rodriguez de Cordoba, S.   +4 more
openaire   +6 more sources

Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. [PDF]

PLoS ONE, 2010
One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B. burgdorferi express up to five distinct complement regulator-acquiring surface proteins (CRASP) which ...
Corinna Siegel, Teresia Hallström, Christine Skerka, Hannes Eberhardt, Barbara Uzonyi, Tobias Beckhaus, Michael Karas, Reinhard Wallich, Brian Stevenson, Peter F Zipfel, Peter Kraiczy   +10 more
doaj   +4 more sources

The complement factor H‐related proteins [PDF]

Immunological Reviews, 2016
SummaryThe role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR
Medjeral-Thomas, N, Pickering, MC
openaire   +4 more sources

Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. [PDF]

J Immunol, 2018
Abstract Factor H (FH) is a key alternative pathway regulator that controls complement activation both in the fluid phase and on specific cell surfaces, thus allowing the innate immune response to discriminate between self and foreign pathogens.
Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM.   +8 more
europepmc   +9 more sources

Factor H-Related Proteins [PDF]

, 2013
Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary. This chapter summarizes our current knowledge on the human factor H-related proteins.
Józsi, Mihály, Meri, Seppo
openaire   +3 more sources

Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4 [PDF]

Frontiers in Immunology, 2018
Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are hypothesized to act as antagonists of the important complement regulator factor H (FH), fine-tuning complement regulation on human
Richard B. Pouw, Richard B. Pouw, Mieke C. Brouwer, Anna E. van Beek, Anna E. van Beek, Mihály Józsi, Diana Wouters, Taco W. Kuijpers, Taco W. Kuijpers   +8 more
doaj   +5 more sources

Polymorphism and deficiency of human factor H-related proteins p39 and p37 [PDF]

Immunogenetics, 1992
We described previously cDNA clones representing a novel factor H-related 1.4 kilobase mRNA. This mRNA species codes for a doublet of serum proteins of M(r) 39,000 and 37,000 (p39/p37). The respective recombinant proteins of the three clones H-69, pFH1.4a, and pFH1.4b differ in the expression of the epitope recognized by the monoclonal antibody (mAb ...
Elisabeth Feifel, Wolfgangm Prodinger, M. Molgg, W. Schwaeble, D. Schonitzer, Vesa Koistinen, MISASI, Roberta, Manfredp Dierich   +7 more
openaire   +4 more sources

Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement. [PDF]

PLoS ONE, 2007
The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues.
Brian Stevenson, Henry A Choy, Marija Pinne, Matthew L Rotondi, M Clarke Miller, Edward Demoll, Peter Kraiczy, Anne E Cooley, Trevor P Creamer, Marc A Suchard, Catherine A Brissette, Ashutosh Verma, David A Haake   +12 more
doaj   +3 more sources