Factor H related proteins modulate complement activation on kidney cells. [PDF]
Kidney Int, 2022 Complement activation at a particular location is determined by the balance of activating and inhibitory proteins. Factor H is a key regulator of the alternative pathway of complement, and genetic or acquired impairments in Factor H are associated with ...
Renner B +12 more
europepmc +5 more sources
Human factor H-related protein 2 (CFHR2) regulates complement activation. [PDF]
PLoS ONE, 2013 Mutations and deletions within the human CFHR gene cluster on chromosome 1 are associated with diseases, such as dense deposit disease, CFHR nephropathy or age-related macular degeneration. Resulting mutant CFHR proteins can affect complement regulation.
Hannes U Eberhardt +10 more
doaj +5 more sources
Dimerization of complement factor H-related proteins modulates complement activation in vivo. [PDF]
Proc Natl Acad Sci U S A, 2013 The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related (CFHR) locus.
Goicoechea de Jorge E +10 more
europepmc +8 more sources
Factor H-related proteins determine complement-activating surfaces. [PDF]
Trends in Immunology, 2015 Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation.
Tortajada, A. +13 more
core +6 more sources
Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. [PDF]
J Immunol, 2018 Factor H (FH) is a key alternative pathway regulator that controls complement activation both in the fluid phase and on specific cell surfaces, thus allowing the innate immune response to discriminate between self and foreign pathogens.
Antonioli AH +8 more
europepmc +6 more sources
Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi. [PDF]
PLoS ONE, 2010 One virulence property of Borrelia burgdorferi is its resistance to innate immunity, in particular to complement-mediated killing. Serum-resistant B. burgdorferi express up to five distinct complement regulator-acquiring surface proteins (CRASP) which ...
Corinna Siegel +10 more
doaj +3 more sources
The complement factor H-related proteins
Immunological Reviews, 2016 The role of the complement factor H‐related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest.
Pickering, MC +3 more
core +4 more sources
, 2013 Factor H-related proteins (CFHRs) are plasma glycoproteins related in structure and antigenicity to each other and to the complement inhibitory protein factor H. Such proteins are found in most mammals but their number and domain composition vary.
Józsi, Mihály +3 more
core +3 more sources
Complement Factor H-Related Protein 4A Is the Dominant Circulating Splice Variant of CFHR4 [PDF]
Frontiers in Immunology, 2018 Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are hypothesized to act as antagonists of the important complement regulator factor H (FH), fine-tuning complement regulation on human
Richard B. Pouw +8 more
doaj +5 more sources
Leptospira interrogans endostatin-like outer membrane proteins bind host fibronectin, laminin and regulators of complement. [PDF]
PLoS ONE, 2007 The pathogenic spirochete Leptospira interrogans disseminates throughout its hosts via the bloodstream, then invades and colonizes a variety of host tissues.
Brian Stevenson +12 more
doaj +2 more sources