Identification of the Gene Encoding the FhbB Protein ofTreponema denticola, a Highly Unique Factor H-Like Protein 1 Binding Protein [PDF]
Infection and Immunity, 2007 ABSTRACTThe gene encoding theTreponema denticolafactor H-like protein 1 (FHL-1) binding protein, FhbB, was recovered and characterized. Sequence conservation, expression, and properties of FhbB were analyzed. The identification of FhbB represents an important step in understanding the contribution of FHL-1 binding inT.
John V, McDowell +3 more
core +7 more sources
C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation. [PDF]
Sci Rep, 2018 AbstractRetinal inflammation plays a key role in the progression of age-related macular degeneration (AMD), a condition that leads to loss of central vision. The deposition of the acute phase pentraxin C-reactive protein (CRP) in the macula activates the complement system, thereby contributing to dysregulated inflammation. The complement protein factor
Swinkels M +8 more
europepmc +5 more sources
Immunobiology, 2023 Factor H is a pivotal complement regulatory protein that is preferentially produced by the liver and circulates in high concentrations in serum. There has been an increasing interest in the extrahepatic production of complement factors, including by cells of the immune system, since this contributes to non-canonical functions of local complement ...
Essen, M.F. van +11 more
core +6 more sources
Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations [PDF]
The American Journal of Human Genetics, 2021 Age-related macular degeneration (AMD) is a leading cause of vision loss; there is strong genetic susceptibility at the complement factor H (CFH) locus. This locus encodes a series of complement regulators: factor H (FH), a splice variant factor-H-like 1 (FHL-1), and five factor-H-related proteins (FHR-1 to FHR-5), all involved in the regulation of ...
Cipriani, Valentina +9 more
openaire +7 more sources
Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration. [PDF]
J Immunol, 2014 Abstract The tight regulation of innate immunity on extracellular matrix (ECM) is a vital part of immune homeostasis throughout the human body, and disruption to this regulation in the eye is thought to contribute directly to the progression of age-related macular degeneration (AMD).
Clark SJ +5 more
europepmc +5 more sources
Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H-like Protein 1 Reveal Functional Determinants of Complement Regulation. [PDF]
J Immunol, 2016 Abstract The serum proteins factor H (FH), consisting of 20 complement control protein modules (CCPs), and its splice product FH-like protein 1 (FHL-1; consisting of CCPs 1–7) are major regulators of the alternative pathway (AP) of complement activation.
Harder MJ +9 more
europepmc +4 more sources
Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na+/K+-ATPase-Beclin-1 interaction [PDF]
Archives of Medical ScienceIntroduction Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption. Methods Male Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised.
Katarina Banjac +3 more
doaj +2 more sources
Molecular Analyses of the Interaction ofBorrelia hermsiiFhbA with the Complement Regulatory Proteins Factor H and Factor H-Like Protein 1 [PDF]
Infection and Immunity, 2006 ABSTRACTBorrelia hermsii, the primary etiological agent of tick-borne relapsing fever in North America, binds the complement regulatory protein factor H (FH) as a means of evading opsonophagocytosis and the alternative complement pathway. The ability of FH-binding protein A (FhbA) to bind FH-like protein 1 (FHL-1) has not been assessed previously.
Kelley M, Hovis +5 more
openaire +5 more sources
Recruitment of Complement Factor H-Like Protein 1 Promotes Intracellular Invasion by Group A Streptococci [PDF]
Infection and Immunity, 2003 ABSTRACTNumerous microbial pathogens exploit complement regulatory proteins such as factor H (FH) and factor H-like protein 1 (FHL-1) for immune evasion. Fba is an FHL-1 and FH binding protein expressed on the surface of the human pathogenic bacterium,Streptococcus pyogenes, a common agent of pharyngeal, skin, and soft-tissue infections. In the present
Vinod, Pandiripally +4 more
openaire +2 more sources
Secretion of soluble complement inhibitors factor H and factor H-like protein (FHL-1) by ovarian tumour cells [PDF]
British Journal of Cancer, 2002 We observed that the soluble complement regulators factor H and factor H-like protein were abundantly present in ascites samples as well as in primary tumours of patients with ovarian cancer. RT-PCR and immunoblotting analyses showed that the two complement inhibitors were constitutively produced by the ovarian tumour cell lines SK-OV-3 and Caov-3, but
Junnikkala, S +7 more
openaire +2 more sources