Results 11 to 20 of about 1,628,545 (288)

Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 Share a Gene but Not All Functions

Frontiers in Immunology, 2020
The alternative pathway regulator Factor H-like protein 1 (FHL-1) is composed of the first 7 N-terminal complement control protein domains of Factor H (FH) and protects host surfaces from uncontrolled complement attack.
Marco Mannes, Arthur Dopler, Markus Huber-Lang, Christoph Q. Schmidt   +3 more
doaj   +1 more source

Secretion of soluble complement inhibitors factor H and factor H-like protein (FHL-1) by ovarian tumour cells [PDF]

British Journal of Cancer, 2002
We observed that the soluble complement regulators factor H and factor H-like protein were abundantly present in ascites samples as well as in primary tumours of patients with ovarian cancer. RT-PCR and immunoblotting analyses showed that the two complement inhibitors were constitutively produced by the ovarian tumour cell lines SK-OV-3 and Caov-3, but
Junnikkala, S, Hakulinen, J, Jarva, H, Manuelian, T, Bjørge, L, Bützow, R, Zipfel, P F, Meri, S   +7 more
openaire   +2 more sources

Impact of the SpeB Protease on Binding of the Complement Regulatory Proteins Factor H and Factor H-Like Protein 1 byStreptococcus pyogenes [PDF]

Infection and Immunity, 2005
ABSTRACTMicrobial pathogens often exploit human complement regulatory proteins such as factor H (FH) and factor H-like protein 1 (FHL-1) for immune evasion. Fba is an FH and FHL-1 binding protein expressed on the surface of the human pathogenic bacteriumStreptococcus pyogenes, a common agent of pharyngeal, skin, and soft-tissue infections. Fba has been
Lin, Wei, Vinod, Pandiripally, Eugene, Gregory, Micaya, Clymer, David, Cue   +4 more
openaire   +2 more sources

The Regulatory Role of Apelin on the Appetite and Growth of Common Carp (Cyprinus Carpio L.)

Animals, 2020
Apelin, a kind of active polypeptide, has many biological functions, such as promoting food intake, enhancing immunity, and regulating energy balance. In mammals, studies have indicated that apelin is involved in regulating food intake.
Xiao Yan, Chaobin Qin, Guokun Yang, Dapeng Deng, Liping Yang, Junchang Feng, Jiali Mi, Guoxing Nie   +7 more
doaj   +1 more source

Glycerol-3-Phosphate Dehydrogenase 2 Is a Novel Factor H–, Factor H–like Protein 1–, and Plasminogen-Binding Surface Protein of Candida albicans [PDF]

The Journal of Infectious Diseases, 2012
Candida albicans uses human complement regulators such as factor H and factor H-like protein 1 (FHL-1) for immune evasion. To define the whole panel of fungal complement-evasion molecules, C. albicans cell extract was absorbed to a factor H-coupled matrix.
Shanshan, Luo, Ralf, Hoffmann, Christine, Skerka, Peter F, Zipfel   +3 more
openaire   +2 more sources

The human complement regulatory factor-H-like protein 1, which represents a truncated form of factor H, displays cell-attachment activity [PDF]

Biochemical Journal, 1997
Complement factor H (FH) and factor-H-like protein 1 (FHL-1) are human plasma proteins with regulatory functions in the alternative pathway of complement activation. FH and FHL-1 are organized in repetitive elements termed short consensus repeats (SCRs) and the seven SCRs of FHL-1 are identical with the N-terminal domain of the 20 SCRs of FH.
J, Hellwage, S, Kühn, P F, Zipfel
openaire   +2 more sources

Exceptional Resistance of Human H2 Glioblastoma Cells to Complement-Mediated Killing by Expression and Utilization of Factor H and Factor H-Like Protein 1 [PDF]

The Journal of Immunology, 2000
Abstract Of over 20 nucleated cell lines we have examined to date, human H2 glioblastoma cells have turned out to be the most resistant to complement-mediated cytolysis in vitro. H2 cells expressed strongly the membrane attack complex inhibitor protectin (CD59), moderately CD46 (membrane cofactor protein) and CD55 (decay-accelerating ...
S, Junnikkala, T S, Jokiranta, M A, Friese, H, Jarva, P F, Zipfel, S, Meri   +5 more
openaire   +2 more sources

Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]

, 2005
Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Nathan W. Bartlett, Geoffrey L. Smith, Haga, Ismar R, Geraldine Maloney, Bowie, Andrew G., Bartlett, Nathan W., Martina Schröder, Ismar R. Haga, Haga, Ismar R., Patrick C. Reading, Andrew G. Bowie, Fitzgerald, Katherine A, Smith, Geoffrey L, Schroeder, Martina, Reading, Patrick C, Smith, Geoffrey L., Katherine A. Fitzgerald, Bartlett, Nathan W, Julianne Stack, Maloney, Geraldine, Bowie, Andrew G, Schröder, Martina, Reading, Patrick C., Stack, Julianne, Fitzgerald, Katherine A.   +24 more
core   +1 more source

Complement-Independent Modulation of Influenza A Virus Infection by Factor H

Frontiers in Immunology, 2020
The complement system is an ancient innate immune defense mechanism that can recognize molecular patterns on the invading pathogens. Factor H, as an inhibitor of the alternative pathway, down-regulates complement activation on the host cell surface ...
Valarmathy Murugaiah, Praveen M. Varghese, Praveen M. Varghese, Soad M. Saleh, Anthony G. Tsolaki, Salman H. Alrokayan, Haseeb A. Khan, Kate S. Collison, Robert B. Sim, Béatrice Nal, Futwan A. Al-Mohanna, Uday Kishore   +11 more
doaj   +1 more source

Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. [PDF]

PLoS ONE, 2016
Complement factor H-related protein 1 (CFHR1) is a complement regulator which has been reported to regulate complement by blocking C5 convertase activity and interfering with C5b surface association. CFHR1 also competes with complement factor H (CFH) for
Jonathan P Hannan, Jennifer Laskowski, Joshua M Thurman, Gregory S Hageman, V Michael Holers   +4 more
doaj   +1 more source