Results 41 to 50 of about 306,625 (170)

Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model

Biomolecules, 2021
Age-related Macular degeneration (AMD) is a degenerative disease of the macula affecting the elderly population. Treatment options are limited, partly due to the lack of understanding of AMD pathology and the lack of suitable research models that ...
Angela Armento, Aparna Murali, Julia Marzi, Ana C Almansa-Garcia, Blanca Arango-Gonzalez, Ellen Kilger, Simon J Clark, Katja Schenke-Layland, Charmaine A Ramlogan-Steel, Jason C Steel, Marius Ueffing   +10 more
doaj   +1 more source

Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein

mSphere, 2019
Meningococcal serogroup B (MenB) vaccines contain recombinant factor H binding protein (FHbp), which can complex with complement factor H (CFH) and thereby risk eliciting anti-FH autoantibodies.
Kelsey Sharkey, Peter T. Beernink, Joanne M. Langley, Soren Gantt, Caroline Quach, Christina Dold, Qin Liu, Manuel Galvan, Dan M. Granoff   +8 more
doaj   +1 more source

Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3

Cell Death and Disease, 2021
Fulminant hepatitis (FH) is an incurable clinical syndrome where novel therapeutics are warranted. Withaferin A (WA), isolated from herb Withania Somnifera, is a hepatoprotective agent.
Yangliu Xia, Ping Wang, Nana Yan, Frank J. Gonzalez, Tingting Yan   +4 more
doaj   +1 more source

Frobenius groups of automorphisms and their fixed points [PDF]

, 2010
Suppose that a finite group $G$ admits a Frobenius group of automorphisms $FH$ with kernel $F$ and complement $H$ such that the fixed-point subgroup of $F$ is trivial: $C_G(F)=1$.
Belyaev V. V., Dade E. C., Evgeny Khukhro, Hall P., Khukhro E. I., Kreknin V. A., Kuzucuoglu M., Lazard M., Mal’cev A. I., Natalia Makarenko, Pavel Shumyatsky   +10 more
core   +2 more sources

Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. [PDF]

PLoS ONE, 2012
Meningococcal factor H binding protein (fHbp) is a promising vaccine candidate. Anti-fHbp antibodies can bind to meningococci and elicit complement-mediated bactericidal activity directly.
Serena Giuntini, Peter T Beernink, Donald C Reason, Dan M Granoff   +3 more
doaj   +1 more source

Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake [PDF]

, 2006
Repeated administration of abused drugs sensitizes their stimulant effects and results in a drug-paired environment eliciting conditioned activity. We tested whether food induces similar effects.
Le Merrer, Julie, Stephens, David N
core   +1 more source

Upregulation of complement proteins in lung cancer cells mediates tumor progression

Frontiers in Oncology, 2023
IntroductionIn vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity.
Emily K. Kleczko, Joanna M. Poczobutt, Andre C. Navarro, Jennifer Laskowski, Amber M. Johnson, Sean P. Korpela, Natalia J. Gurule, Lynn E. Heasley, Katharina Hopp, Mary C.M. Weiser-Evans, Elizabeth B. Gottlin, Ryan T. Bushey, Michael J. Campa, Edward F. Patz, Edward F. Patz, Joshua M. Thurman, Raphael A. Nemenoff   +16 more
doaj   +1 more source

Meningococcal factor H binding protein fHbpd184 polymorphism influences clinical course of meningococcal meningitis. [PDF]

PLoS ONE, 2012
Factor H Binding protein (fHbp) is an important meningococcal virulence factor, enabling the meningococcus to evade the complement system, and a main target for vaccination. Recently, the structure of fHBP complexed with factor H (fH) was published.
Jurgen R Piet, Matthijs C Brouwer, Rachel Exley, Stijn van der Veen, Diederik van de Beek, Arie van der Ende   +5 more
doaj   +1 more source

mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells

Antioxidants, 2021
Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices.
David A. Merle, Francesca Provenzano, Mohamed Ali Jarboui, Ellen Kilger, Simon J. Clark, Michela Deleidi, Angela Armento, Marius Ueffing   +7 more
doaj   +1 more source

Standard Model Parton Distributions at Very High Energies [PDF]

, 2017
We compute the leading-order evolution of parton distribution functions for all the Standard Model fermions and bosons up to energy scales far above the electroweak scale, where electroweak symmetry is restored.
Bauer, Christian W., Ferland, Nicolas, Webber, Bryan R.   +2 more
core   +2 more sources