Results 41 to 50 of about 16,055,310 (231)

Structure of an active N-terminal fragment of human complement factor H [PDF]

, 2008
Factor H (FH) is a key regulator of the complement system, the principal molecular component of innate immunity in humans. The tight regulation of the alternative pathway (AP) of complement by FH occurs on host cells as well as in fluid phase.
Hocking, Henry G.
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization

Molecular Therapy: Methods & Clinical Development, 2018
Complement activation plays a significant role in age-related macular degeneration (AMD) pathogenesis, and polymorphisms interfering with factor H (fH) function, a complement alternative pathway (AP) inhibitor, are associated with increased AMD risk.
Gloriane Schnabolk, Nathaniel Parsons, Elisabeth Obert, Balasubramaniam Annamalai, Cecile Nasarre, Stephen Tomlinson, Alfred S. Lewin, Bärbel Rohrer   +7 more
doaj   +1 more source

Anti-Factor H Antibodies in Egyptian Children with Hemolytic Uremic Syndrome

International Journal of Nephrology, 2021
Background. Atypical hemolytic uremic syndrome (aHUS) is an important cause of acute kidney injury in children. It is primarily caused by dysregulation of the complement alternative pathway due to genetic mutations, mainly in complement factor H genes ...
Shereen Shawky, Hesham Safouh, Mona Gamal, Mohammed M. Abbas, Azza Aboul-Enein, Toshihiro Sawai, Yosra Fahmy, Heba Selim   +7 more
doaj   +1 more source

Contribution of functional and quantitative genetic variants of Complement Factor H and Factor H-Related (FHR) proteins on renal pathology

Nefrología (English Edition), 2022
The complement system is a first line of defence against infectious, tumoral or autoimmune processes, and it is constitutively regulated to avoid excessive or unspecific activation. Factor H (FH), a most relevant complement regulator, controls complement
Irene Gómez Delgado, Pilar Sánchez-Corral   +1 more
doaj   +1 more source

Factor H-related proteins determine complement-activating surfaces. [PDF]

, 2015
Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation.
Tortajada, A., Barbara Uzonyi, Agustin Tortajada, Rodriguez de Cordoba, S., Mihály Józsi, Rodriguez de Cordoba, Santiago, Goicoechea De Jorge, Elena, Mihaly, Jozsi, Tortajada Alonso, Agustín, Santiago Rodríguez de Córdoba, Józsi, Mihály, Elena Goicoechea de Jorge, Goicoechea de, Jorge E., Uzonyi, Barbara   +13 more
core   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

A Neighborhood Condition for Fractional ID-[A, B]-Factor-Critical Graphs

Discussiones Mathematicae Graph Theory, 2016
Let G be a graph of order n, and let a and b be two integers with 1 ≤ a ≤ b. Let h : E(G) → [0, 1] be a function. If a ≤ ∑e∋x h(e) ≤ b holds for any x ∈ V (G), then we call G[Fh] a fractional [a, b]-factor of G with indicator function h, where Fh = {e ...
Zhou Sizhong, Yang Fan, Sun Zhiren
doaj   +1 more source

A Factor H-Fc fusion protein increases complement-mediated opsonophagocytosis and killing of community associated methicillin-resistant Staphylococcus aureus.

PLoS ONE, 2022
Staphylococcus aureus employs a multitude of immune-evasive tactics to circumvent host defenses including the complement system, a component of innate immunity central to controlling bacterial infections.
Megan A G Sage, Katelyn D Cranmer, Michele L Semeraro, Shelby Ma, Elena V Galkina, Y Tran, Keith L Wycoff, Julia A Sharp   +7 more
doaj   +1 more source