Results 61 to 70 of about 306,625 (170)

Cloning, expression and purification of the factor H binding protein and its interaction with factor H

Iranian Journal of Microbiology, 2016
Background and Objective: Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. The factor H binding protein (fHBP) is a key virulence factor of Neisseria meningitidis that is able to selectively bind to human factor H, the key ...
Fatemeh Yarian, Mojgan Bandehpour, Negar Seyed, Bahram kazemi   +3 more
doaj  

A Factor H-Fc fusion protein increases complement-mediated opsonophagocytosis and killing of community associated methicillin-resistant Staphylococcus aureus.

PLoS ONE, 2022
Staphylococcus aureus employs a multitude of immune-evasive tactics to circumvent host defenses including the complement system, a component of innate immunity central to controlling bacterial infections.
Megan A G Sage, Katelyn D Cranmer, Michele L Semeraro, Shelby Ma, Elena V Galkina, Y Tran, Keith L Wycoff, Julia A Sharp   +7 more
doaj   +1 more source

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice [PDF]

, 2019
Atypical hemolytic uremic syndrome (aHUS) is frequently associated in humans with loss-of-function mutations in complement-regulating proteins or gain-of-function mutations in complement-activating proteins.
Atkinson, John P, Barlow, Paul N, Cook, H. T, Cooke, Katie, Denton, Harriet, Kavanagh, David, Liszewski, M. K, Marchbank, Kevin J, Pappworth, Isabel Y, Pickering, Matthew C, Smith-Jackson, Kate, Yang, Yi   +11 more
core   +3 more sources

Virtual signatures of dark sectors in Higgs couplings [PDF]

, 2004
Where collider searches for resonant invisible particles loose steam, dark sectors might leave their trace as virtual effects in precision observables. Here we explore this option in the framework of Higgs portal models, where a sector of dark fermions ...
Alexander Voigt, Susanne Westhoff, M Srednicki, EW Kolb, P Gondolo, GW Anderson, A Joglekar, MA Fedderke, T Appelquist, S Fichet, F D’Eramo, R Enberg, J Kearney, L Calibbi, A Freitas, A Denner, JR Ellis, SL Glashow, DRT Jones, T Corbett, ME Peskin, J Fan, C Cai, W Altmannshofer, D Buttazzo, H Davoudiasl, M Fairbairn, G Durieux, G Degrassi, W Bizon, S Gori, P Schwaller, N Craig, R Mertig, F Staub   +34 more
core   +1 more source

Factor H-related protein 1 promotes complement-mediated opsonization of Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology
Pseudomonas aeruginosa is an important human opportunistic pathogen responsible for a wide range of infections. The complement system is the main early host defense mechanism to control these infections. P.
Alex González-Alsina, Héctor Martín-Merinero, Margalida Mateu-Borrás, María Verd, Antonio Doménech-Sánchez, Joanna B. Goldberg, Santiago Rodríguez de Córdoba, Sebastián Albertí   +7 more
doaj   +1 more source

Immune evasion of Borrelia miyamotoi: CbiA, a novel outer surface protein exhibiting complement binding and inactivating properties

Scientific Reports, 2017
Borrelia (B.) miyamotoi, an emerging tick-borne relapsing fever spirochete, resists complement-mediated killing. To decipher the molecular principles of immune evasion, we sought to identify determinants contributing to complement resistance.
Florian Röttgerding, Alex Wagemakers, Joris Koetsveld, Volker Fingerle, Michael Kirschfink, Joppe W. Hovius, Peter F. Zipfel, Reinhard Wallich, Peter Kraiczy   +8 more
doaj   +1 more source

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 Glomerulopathies

Frontiers in Immunology, 2021
Complement dysregulation is characteristic of the renal diseases atypical hemolytic uremic syndrome (aHUS) and complement component 3 glomerulopathy (C3G).
Markus A. Loeven, Marissa L. Maciej-Hulme, Cansu Yanginlar, Melanie C. Hubers, Edwin Kellenbach, Mark de Graaf, Toin H. van Kuppevelt, Jack Wetzels, Ton J. Rabelink, Richard J. H. Smith, Johan van der Vlag   +10 more
doaj   +1 more source

Attention-Aware Face Hallucination via Deep Reinforcement Learning

, 2017
Face hallucination is a domain-specific super-resolution problem with the goal to generate high-resolution (HR) faces from low-resolution (LR) input images.
Cao, Qingxing, Li, Guanbin, Liang, Xiaodan, Lin, Liang, Shi, Yukai   +4 more
core   +1 more source

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH

Frontiers in Immunology
Factor H-related proteins (FHRs) are found in mice, but their equivalence to human FHRs remains uncertain. This study identifies three FHRs in mouse plasma (FHR-B, FHR-C, and FHR-E) and focuses on characterizing FHR-B. Using purified plasma proteins and recombinant mutants, FHR-B was found to form dimers and bind strongly to C3, C3b, iC3b, and C3dg. It
Martín-Ambrosio Doménech, Adrián, González Sanz, Silvia, Márquez Tirado, Bárbara, Juana-López, Lucia, Goicoechea de Jorge, Elena, Rodríguez de Córdoba, Santiago, Martín Merinero, Héctor   +6 more
openaire   +4 more sources

Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Scientific Reports
Factor H (FH) is a negative regulator of the alternative pathway (AP) of complement however, five human factor H-related (FHR) proteins, can also function ex vivo as positive regulators.
Nirmal K. Banda, Larry W. Moreland, Kevin D. Deane, Dmitri Simberg, Robert I. Scheinman, Rachel M. Frank, Jennifer A. Seifert, Accelerating Medicines Partnership (AMP) RA/SLE Network, Rachel Lau, Costantino Pitzalis, Myles J. Lewis, V. Michael Holers   +11 more
doaj   +1 more source