Results 21 to 30 of about 16,055,310 (231)

Self-Damage Caused by Dysregulation of the Complement Alternative Pathway: Relevance of the Factor H Protein Family

Frontiers in Immunology, 2018
The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways.
Pilar Sánchez-Corral, Richard B. Pouw, Margarita López-Trascasa, Margarita López-Trascasa, Mihály Józsi, Mihály Józsi   +5 more
doaj   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation. [PDF]

Adv Sci (Weinh)
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Tian Y, Ma S, Yang B, Gao F, Guo H, Liu H, Wu X, Cui W, Dong J, Lin Q, Ge Y, Ma J, Zhao J, Zhang Y, Xue D, Tian J, Zhang Z, Wang K, Xu M, Feng D, Zhou J, Qu Y.   +21 more
europepmc   +2 more sources

Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human

BMC Research Notes, 2009
Background Borreliae employ multiple immune evasive strategies such as binding to complement regulatory proteins [factor H (fH) and factor H like-1 (FHL1)], differential regulation of surface membrane proteins, antigenic variation, and binding of ...
Gil Horacio, Camafeita Emilio, Escudero Raquel, Bhide Mangesh R, Jado Isabel, Anda Pedro   +5 more
doaj   +1 more source

Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis

Frontiers in Immunology, 2022
Neisseria meningitidis, the causative agent of meningococcal disease (MD), evades complement-mediated clearance upon infection by ‘hijacking’ the human complement regulator factor H (FH).
Anna E. van Beek, Anna E. van Beek, Richard B. Pouw, Richard B. Pouw, Victoria J. Wright, Neneh Sallah, David Inwald, Clive Hoggart, Mieke C. Brouwer, Rachel Galassini, John Thomas, Leo Calvo-Bado, Colin G. Fink, Ilse Jongerius, Ilse Jongerius, Martin Hibberd, Diana Wouters, Michael Levin, Taco W. Kuijpers, Taco W. Kuijpers   +19 more
doaj   +1 more source

Changes in complement alternative pathway components, factor B and factor H during dengue virus infection in the AG129 mouse [PDF]

, 2021
The complement alternative pathway (AP) is tightly regulated and changes in two important AP components, factor B (FB) and factor H (FH) are linked to severe dengue in humans. Here, a mouse model of dengue was investigated to define the changes in FB and
Ong, Li-Ching, Klebe, Sonja, Gordon, David L, Alonso, Sylvie, Cabezas-Falcon, Sheila, Adamson, Penelope, Mahalingam, Suresh, Hulme-Jones, Jarrod, Rudd, Penny A, Norbury, Aidan J, Carr, Jillian M, Li-Ching Ong, Jarrod Hulme-Jones, Aidan J. Norbury, Penelope Adamson, Penny A. Rudd, Sylvie Alonso, David L. Gordon, Suresh Mahalingam, Jillian M. Carr, Sheila Cabezas-Falcon, Sonja Klebe   +21 more
core   +1 more source

A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine

mBio, 2019
MenB-4C (Bexsero; GlaxoSmithKline Biologicals) is a licensed meningococcal vaccine for capsular B strains. The vaccine contains detergent-extracted outer membrane vesicles (dOMV) and three recombinant proteins, of which one is factor H binding protein ...
Peter T. Beernink, Vianca Vianzon, Lisa A. Lewis, Gregory R. Moe, Dan M. Granoff   +4 more
doaj   +1 more source

Complement Factor H Loss in RPE Cells Causes Retinal Degeneration in a Human RPE-Porcine Retinal Explant Co-Culture Model

Biomolecules, 2021
Age-related Macular degeneration (AMD) is a degenerative disease of the macula affecting the elderly population. Treatment options are limited, partly due to the lack of understanding of AMD pathology and the lack of suitable research models that ...
Angela Armento, Aparna Murali, Julia Marzi, Ana C Almansa-Garcia, Blanca Arango-Gonzalez, Ellen Kilger, Simon J Clark, Katja Schenke-Layland, Charmaine A Ramlogan-Steel, Jason C Steel, Marius Ueffing   +10 more
doaj   +1 more source

Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy

, 2017
IgA nephropathy (IgAN), a frequent cause of chronic kidney disease worldwide, is characterized by mesangial deposition of galactose-deficient IgA1-containing immune complexes.
Gutiérrez Tenorio, Josué, Rodriguez de Cordoba, Santiago, Goicoechea De Jorge, Elena, Tortajada Alonso, Agustín, Praga Terente, Manuel, Gutiérrez Rivas, Eduardo José   +5 more
core   +2 more sources

Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein

mSphere, 2019
Meningococcal serogroup B (MenB) vaccines contain recombinant factor H binding protein (FHbp), which can complex with complement factor H (CFH) and thereby risk eliciting anti-FH autoantibodies.
Kelsey Sharkey, Peter T. Beernink, Joanne M. Langley, Soren Gantt, Caroline Quach, Christina Dold, Qin Liu, Manuel Galvan, Dan M. Granoff   +8 more
doaj   +1 more source

Interaction of Human Complement Factor H Variants Tyr402 and His 402 with Leptospira spp.

Frontiers in Immunology, 2011
Leptospirosis is a zoonosis caused by pathogenic bacteria from the genus Leptospira. The disease represents a serious public health problem in underdeveloped tropical countries.
Aldacilene Souza Silva, Mónica Marcela Castiblanco Valencia, Aurora Marques Cianciarullo, Silvio Arruda Vasconcellos, Angela Silva Barbosa, Lourdes eIsaac   +5 more
doaj   +1 more source