A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens. [PDF]
PLoS ONE, 2015 Factor H binding protein (FHbp) is a virulence factor used by meningococci to evade the host complement system. FHbp elicits bactericidal antibodies in humans and is part of two recently licensed vaccines.
Monica Konar +4 more
doaj +1 more source
The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity [PDF]
, 2009 38 p.- 7 fig.Mutations and polymorphisms in the gene encoding factor H (CFH) have been associated with atypical haemolytic uraemic syndrome, dense deposit disease and age-related macular degeneration.
de Cordoba, Santiago Rodriguez +5 more
core +1 more source
Factor H-Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation. [PDF]
, 2015 The physiological roles of the factor H (FH)-related proteins are controversial and poorly understood. Based on genetic studies, FH-related protein 5 (CFHR5) is implicated in glomerular diseases, such as atypical hemolytic uremic syndrome, dense deposit
Bánlaki, Zsófia +5 more
core +1 more source
Histology and histopathology, 2005 Factor H (FH) is the predominant soluble inhibitor of the complement system. With a concentration of 200-800 microg/ml in human and rat plasma it acts as a cofactor for the soluble factor I (FI)-mediated cleavage of the component C3b to iC3b. Furthermore it competes with factor B for binding to C3b and C3(H2O) and promotes the dissociation of the C3bBb
Demberg, T. +5 more
openaire +3 more sources
Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein
mBio, 2015 Two licensed serogroup B meningococcal vaccines contain factor H binding protein (FHbp). The antigen specifically binds human FH, which downregulates complement.
Peter T. Beernink +4 more
doaj +1 more source
Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome [PDF]
, 2017 Introduction: In autoimmune atypical hemolytic uremic syndrome (aHUS), the complement regulator factor H (FH) is blocked by FH autoantibodies, while 90% of the patients carry a homozygous deletion of its homolog complement FH-related protein 1 (CFHR1 ...
Arbeiter, Klaus +16 more
core +2 more sources
The possible role of factor H in complement activation-related pseudoallergy (CARPA): a failed attempt to correlate blood levels of FH with liposome-induced hypersensitivity reactions in patients with autoimmune disease [PDF]
European Journal of Nanomedicine, 2015 AbstractFactor H (FH) is a natural inhibitor of the alternative pathway (AP) of complement (C) activation, an abundant protein in blood whose reduced level has been associated with proneness for increased C activation. There are also 5 FH-related proteins (FHR), which have different impacts on C function.
Fülöp, Tamas Gyula +5 more
openaire +3 more sources
Microbes Bind Complement Inhibitor Factor H via a Common Site [PDF]
, 2013 To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma
A Bhattacharjee +54 more
core +4 more sources
Frontiers in Immunology, 2018 The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways.
Pilar Sánchez-Corral +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS), characterized by pathogenic, complement-activating autoantibodies against the main water channel in the CNS, aquaporin 4 (AQP4 ...
Barbara Uzonyi +17 more
doaj +1 more source