Results 11 to 20 of about 16,055,310 (231)

MS/MS spectra for nano-LC/MS/MS for human Factor H (FH) before and after the treatment of PG0352.

, 2023
MS/MS spectra for nano-LC/MS/MS for human Factor H (FH) before and after the treatment of PG0352.
Kurni Kurniyati (9588578), Qin Fu (143723), Nicholas D. Clark (17041646), Laurynn Coleman (17041649), Sheng Zhang (111330), Michael G. Malkowski (1453513), Chunhao Li (5949533), Christopher Pham (666018), Ching Wooen Sze (4423360)   +8 more
core   +1 more source

Binding of Complement Factor H (FH) Decreases Protective Anti-FH Binding Protein Antibody Responses of Infant Rhesus Macaques Immunized With a Meningococcal Serogroup B Vaccine. [PDF]

J Infect Dis, 2015
BACKGROUND: The meningococcal vaccine antigen, factor H (FH)-binding protein (FHbp), binds human complement FH. In human FH transgenic mice, binding decreased protective antibody responses.
Granoff DM, Costa I, Konar M, Giuntini S, Van Rompay KK, Beernink PT.   +5 more
europepmc   +2 more sources

The Factor H protein family: The switchers of the complement alternative pathway [PDF]

, 2022
CRUE-CSIC (Acuerdos Transformativos 2022)The factor H (FH) protein family is emerging as a complex network of proteins controlling the fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range of diseases including ...
Márquez Tirado, Bárbara, Lucientes Continente, Laura, Márquez-Tirado, Bárbara, Goicoechea de Jorge, Elena, Bárbara Márquez‐Tirado, Lucientes-Continente, Laura, Laura Lucientes‐Continente, Elena Goicoechea de Jorge   +7 more
core   +1 more source

A rare association between factor H deficiency and lupus: Case report and experimental treatment with curcumin

Frontiers in Pediatrics, 2022
Factor H (FH) is one of the most important regulatory proteins of the alternative pathway of the complement system. FH deficiency is a rare condition that causes unregulated C3 consumption, leading to an increased susceptibility to infections and ...
Ana Catarina Lunz Macedo, Ana Catarina Lunz Macedo, Lazara Elena Santisteban Lores, José Antonio Tavares Albuquerque, Nilo José Coelho Duarte, Paschoalina Romano, Persio Almeida Rezende Ebner, Vinicius Marcondes Rezende, Clovis A. Silva, Luís Eduardo Coelho Andrade, Dewton Moraes Vasconcelos, Lourdes Isaac   +11 more
doaj   +1 more source

A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp. [PDF]

PLoS ONE, 2015
Two meningococcal serogroup B vaccines contain Factor H binding protein (FHbp). Binding of Factor H (FH) to FHbp was thought to be specific for human or chimpanzee FH. However, in a previous study an amino acid polymorphism in rhesus macaque FH domain 6,
Monica Konar, Peter T Beernink, Dan M Granoff   +2 more
doaj   +1 more source

Structural basis for complement factor H-linked age-related macular degeneration [PDF]

, 2007
Nearly 50 million people worldwide suffer from age-related macular degeneration (AMD), which causes severe loss of central vision. A single-nucleotide polymorphism in the gene for the complement regulator factor H (FH), which causes a Tyr-to-His ...
Pietro Roversi, Robert B. Sim, Susan M. Lea, Jowitt, Thomas A., Beverly E. Prosser, Prosser, Beverly E., Day, Anthony J., Herbert, AP, Dušan Uhrín, Sim, Robert B., Uhrin, Dusan, Johnson, S, Steven Johnson, Blaum, Barbel S., Barlow, Paul N., Barlow, PN, Sim, RB, Simon J. Clark, Johnson, Steven, Thomas A. Jowitt, Jowitt, Thomas A.; id_orcid, Edward Tarelli, Jess Tyrrell, Lea, Susan M., Tyrrell, J, Blaum, BS, Herbert, Andrew P., Clark, Simon J., Tyrrell, Jess, Day, Anthony J.; id_orcid, Lea, Susan, Tarelli, E, Clark, SJ, Paul N. Barlow, Bärbel S. Blaum, Clark, Simon; id_orcid, Tarelli, Edward, Prosser, BE, Jowitt, TA, Day, AJ, Andrew P. Herbert, Roversi, Pietro, Anthony J. Day, Barlow P. N., Jowitt T. A., Herbert A. P., Johnson S., Tarelli E., Sim R. B., Uhrin D., Prosser B. E., Roversi P., Tyrrell J., Day A. J., Lea S. M., Blaum B. S., Clark S. J., Uhrín, D   +57 more
core   +1 more source

Recombinant complement factor H in complement-mediated diseases [PDF]

, 2022
Complement Factor H (FH) is a 155-kDa plasma glycoprotein that regulates the alternative pathway of the complement system. Mutations or deficiencies in FH are associated with some cases of the kidney diseases C3 glomerulopathy and atypical ...
Kerr, Heather
core   +1 more source

A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens. [PDF]

PLoS ONE, 2015
Factor H binding protein (FHbp) is a virulence factor used by meningococci to evade the host complement system. FHbp elicits bactericidal antibodies in humans and is part of two recently licensed vaccines.
Monica Konar, Raffaella Rossi, Helen Walter, Rolando Pajon, Peter T Beernink   +4 more
doaj   +1 more source

Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein

mBio, 2015
Two licensed serogroup B meningococcal vaccines contain factor H binding protein (FHbp). The antigen specifically binds human FH, which downregulates complement.
Peter T. Beernink, Serena Giuntini, Isabella Costa, Alexander H. Lucas, Dan M. Granoff   +4 more
doaj   +1 more source

Autoantibodies Against the Complement Regulator Factor H in the Serum of Patients With Neuromyelitis Optica Spectrum Disorder

Frontiers in Immunology, 2021
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS), characterized by pathogenic, complement-activating autoantibodies against the main water channel in the CNS, aquaporin 4 (AQP4 ...
Barbara Uzonyi, Barbara Uzonyi, Zsóka Szabó, Eszter Trojnár, Eszter Trojnár, Satu Hyvärinen, Katalin Uray, Helle H. Nielsen, Anna Erdei, Anna Erdei, T. Sakari Jokiranta, Zoltán Prohászka, Zoltán Prohászka, Zsolt Illes, Zsolt Illes, Mihály Józsi, Mihály Józsi, Mihály Józsi   +17 more
doaj   +1 more source