The interaction between factor H and Von Willebrand factor. [PDF]
PLoS ONE, 2013 Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS).
Shuju Feng +8 more
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Mechanism of Borrelia immune evasion by FhbA-related proteins.
PLoS Pathogens, 2022 Immune evasion facilitates survival of Borrelia, leading to infections like relapsing fever and Lyme disease. Important mechanism for complement evasion is acquisition of the main host complement inhibitor, factor H (FH). By determining the 2.2 Å crystal
Konstantin Kogan +6 more
doaj +1 more source
Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions
Frontiers in Immunology, 2021 Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti +7 more
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Human Vaccines & Immunotherapeutics, 2020 Bacteria produce surface ligands for host complement regulators including Factor H (FH), which allows the bacteria to evade immunity. Meningococcal Factor H binding protein (FHbp) is both a virulence factor and a vaccine antigen.
Peter T. Beernink
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Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex [PDF]
, 2016 Introduction Coagulation and complement systems are simultaneously activated at sites of tissue injury, leading to thrombin generation and opsonisation with C3b.
Baerga-Ortiz +58 more
core +2 more sources
Frontiers in Pediatrics, 2022 Factor H (FH) is one of the most important regulatory proteins of the alternative pathway of the complement system. FH deficiency is a rare condition that causes unregulated C3 consumption, leading to an increased susceptibility to infections and ...
Ana Catarina Lunz Macedo +11 more
doaj +1 more source
A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp. [PDF]
PLoS ONE, 2015 Two meningococcal serogroup B vaccines contain Factor H binding protein (FHbp). Binding of Factor H (FH) to FHbp was thought to be specific for human or chimpanzee FH. However, in a previous study an amino acid polymorphism in rhesus macaque FH domain 6,
Monica Konar +2 more
doaj +1 more source
Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome [PDF]
, 2007 The atypical form of the kidney disease hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. In addition to mutations in complement regulators, factor H (FH)-specific autoantibodies have been reported for aHUS patients ...
Dahse, H. M. +4 more
core +1 more source
FHR-1 binds to C-reactive protein and enhances rather than inhibits complement activation [PDF]
, 2017 Factor H (FH)-related protein 1 (FHR-1) is one of the five human factor H-related proteins, which share sequence and structural homology with the alternative pathway complement inhibitor FH.
Bánlaki, Zsófia +7 more
core +1 more source
Rapid isolation of pure Complement Factor H from serum for functional studies by the use of a monoclonal antibody that discriminates FH from all the other isoforms [PDF]
Molecular Immunology, 2016 Several mutations have been identified in the gene coding for Complement Factor H (FH) from patients with atypical Hemolytic Uraemic Syndrome (aHUS), Age-related Macular Degeneration (AMD) and Membranoproliferative Glomerulonephritis (MPGN). These data allow for a precise description of the structural changes affecting FH, but a simple test for ...
S. Berra, A. Clivio
openaire +3 more sources