Results 31 to 40 of about 16,055,310 (231)
Withaferin A alleviates fulminant hepatitis by targeting macrophage and NLRP3
Cell Death and Disease, 2021 Fulminant hepatitis (FH) is an incurable clinical syndrome where novel therapeutics are warranted. Withaferin A (WA), isolated from herb Withania Somnifera, is a hepatoprotective agent.
Yangliu Xia +4 more
doaj +1 more source
Upregulation of complement proteins in lung cancer cells mediates tumor progression
Frontiers in Oncology, 2023 IntroductionIn vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity.
Emily K. Kleczko +16 more
doaj +1 more source
, 2013 Mass spectrometry of fH-binding proteins detected via factor-H overlay identifying both SdrE and ClfA peptides.
Julia A. Sharp (320880) +7 more
core +1 more source
Monoclonal antibodies to meningococcal factor H binding protein with overlapping epitopes and discordant functional activity. [PDF]
PLoS ONE, 2012 Meningococcal factor H binding protein (fHbp) is a promising vaccine candidate. Anti-fHbp antibodies can bind to meningococci and elicit complement-mediated bactericidal activity directly.
Serena Giuntini +3 more
doaj +1 more source
Meningococcal factor H binding protein fHbpd184 polymorphism influences clinical course of meningococcal meningitis. [PDF]
PLoS ONE, 2012 Factor H Binding protein (fHbp) is an important meningococcal virulence factor, enabling the meningococcus to evade the complement system, and a main target for vaccination. Recently, the structure of fHBP complexed with factor H (fH) was published.
Jurgen R Piet +5 more
doaj +1 more source
Antioxidants, 2021 Age-related macular degeneration (AMD) is a complex degenerative disease of the retina with multiple risk-modifying factors, including aging, genetics, and lifestyle choices.
David A. Merle +7 more
doaj +1 more source
Complement Factor H: solution structures and interactions with ligands [PDF]
, 2009 Factor H (FH) is a plasma glycoprotein that plays a central role in regulating the alternative pathway of complement. It is composed of 20 short complement regulator (SCR) domains.
Okemefuna, A.I.
core
Factor H enhances ADAMTS-13-mediated cleavage of recombinant FRETS-VWF73 and ULVWF.
, 2013 (A) Cleavage of ADAMTS-13 substrate (FRETS-VWF73) at different concentrations of fH was quantified using a commercial kit (ATS-13, Gen-Probe). Polyclonal anti-fH antibody (100 nM) was used to block the effect of fH on ADAMTS-13-mediated cleavage of the ...
Vahid Afshar-Kharghan (450560) +8 more
core +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Nefrología, 2022 Resumen: El sistema del Complemento protege al organismo frente a procesos infecciosos, tumorales y autoinmunes, y requiere una regulación muy estricta para evitar una activación excesiva o inespecífica.
Irene Gómez Delgado +1 more
doaj +1 more source