Results 31 to 40 of about 306,625 (170)

Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human

BMC Research Notes, 2009
Background Borreliae employ multiple immune evasive strategies such as binding to complement regulatory proteins [factor H (fH) and factor H like-1 (FHL1)], differential regulation of surface membrane proteins, antigenic variation, and binding of ...
Gil Horacio, Camafeita Emilio, Escudero Raquel, Bhide Mangesh R, Jado Isabel, Anda Pedro   +5 more
doaj   +1 more source

Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis

Frontiers in Immunology, 2022
Neisseria meningitidis, the causative agent of meningococcal disease (MD), evades complement-mediated clearance upon infection by ‘hijacking’ the human complement regulator factor H (FH).
Anna E. van Beek, Anna E. van Beek, Richard B. Pouw, Richard B. Pouw, Victoria J. Wright, Neneh Sallah, David Inwald, Clive Hoggart, Mieke C. Brouwer, Rachel Galassini, John Thomas, Leo Calvo-Bado, Colin G. Fink, Ilse Jongerius, Ilse Jongerius, Martin Hibberd, Diana Wouters, Michael Levin, Taco W. Kuijpers, Taco W. Kuijpers   +19 more
doaj   +1 more source

Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi [PDF]

, 2017
Complement is an important part of innate immunity. The alternative pathway of complement is activated when the main opsonin, C3b coats non-protected surfaces leading to opsonisation, phagocytosis and cell lysis.
A Bhattacharjee, A Richards, Adrian Goldman, AJ McCoy, AO Edwards, B Nagar, BS Blaum, C Hammerschmidt, C Siegel, CA Diebolder, Catherine A. Brissette, D Weismann, DE Isenman, DL Gordon, E Goicoechea de Jorge, E Krissinel, EM Adams, J Esparza-Gordillo, J Hellwage, J Pietikäinen, J Wu, JD Lambris, JH Williams Jr., JJ Caesar, JJ Caesar, JM van den Elsen, JM Weiler, K Brangulis, K Haupt, K Whaley, Kornelia M. Mikula, M Jozsi, M Jozsi, M Jozsi, MC Carroll, MD Winn, MJ Lehtinen, MJ Lehtinen, MJ Walport, MK Pangburn, P Emsley, P Kraiczy, PD Adams, PF Zipfel, PW Dempsey, RB Sim, Robert Kolodziejczyk, S Breitner-Ruddock, S Hyvärinen, S Kühn, S Ram, T Kajander, T Meri, T. Sakari Jokiranta, Taru Meri, Tommi Kotila, TS Jokiranta, Vincent L. G. Postis, W Kabsch   +58 more
core   +5 more sources

Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants [PDF]

, 2017
Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the ...
Adán Civera, Alfredo, Antón, Rosa, Aróstegui Gorospe, Juan Ignacio, Dick, Andrew D., Fuentes Prior, Pablo, Molins Monteys, Blanca, Yagüe, Jordi   +6 more
core   +1 more source

A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine

mBio, 2019
MenB-4C (Bexsero; GlaxoSmithKline Biologicals) is a licensed meningococcal vaccine for capsular B strains. The vaccine contains detergent-extracted outer membrane vesicles (dOMV) and three recombinant proteins, of which one is factor H binding protein ...
Peter T. Beernink, Vianca Vianzon, Lisa A. Lewis, Gregory R. Moe, Dan M. Granoff   +4 more
doaj   +1 more source

Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting. [PDF]

, 2019
The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research,
Bristow, Claire C, Cristillo, Anthony D, Dillon, Jo-Anne, Dong, Huan, Grad, Yonatan H, Kirkcaldy, Robert D, Klausner, Jeffrey D, Lawrence, Kenneth, Morris, Sheldon R, Nicholas, Robert A, Oldach, David, Rice, Peter A, Shafer, William Maurice, Torrone, Elizabeth, Wi, Teodora E, Zhou, Pei   +15 more
core   +1 more source

Factor H (FH) Is Released Slowly and Continuously from Human Endothelial Cells (ECs): FH Is Not Packaged in Weibel-Palade Bodies or Secreted in Response to EC Stimulation

Blood, 2014
Abstract Introduction Ultra-large von Willebrand factor (ULVWF) strings are synthesized in ECs, packaged in Weibel-Palade Bodies (WPBs), and secreted by stimulated ECs. Complement components studied to date [C3, factor (F) B, FD, FP, FH, FI, C5] are released slowly and continuously from human umbilical vein endothelial ...
Sarah E Sartain, Nancy A Turner, Hui Shiu-Ki, Charles G. Minard, Joel L Moake   +4 more
openaire   +1 more source

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode [PDF]

, 2016
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Atkinson, John P, Bertram, Paula, Forneris, Federico, Granneman, Joke CM, Gros, Piet, Hauhart, Richard, Lambris, John D, Lin, Zhuoer, Liszewski, M. Kathryn, Ricklin, Daniel, Sfyroera, Georgia, Tzekou, Apostolia, Volokhina, Elena, Wu, Jin, Xue, Xiaoguang   +14 more
core   +2 more sources

Complement system biomarkers in first episode psychosis [PDF]

, 2019
Several lines of evidence implicate immunological/inflammatory factors in development of schizophrenia. Complement is a key driver of inflammation, and complement dysregulation causes pathology in many diseases.
Di Forti, Marta, Gaughran, Fiona, Kopczynska, Maja, Mondelli, Valeria, Morgan, B. Paul, Murray, Robin, O'Donovan, Michael, Touchard, Samuel, Zelek, Wioleta   +8 more
core   +2 more sources

Interaction of Human Complement Factor H Variants Tyr402 and His 402 with Leptospira spp.

Frontiers in Immunology, 2011
Leptospirosis is a zoonosis caused by pathogenic bacteria from the genus Leptospira. The disease represents a serious public health problem in underdeveloped tropical countries.
Aldacilene Souza Silva, Mónica Marcela Castiblanco Valencia, Aurora Marques Cianciarullo, Silvio Arruda Vasconcellos, Angela Silva Barbosa, Lourdes eIsaac   +5 more
doaj   +1 more source