Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization [PDF]
Frontiers in Immunology, 2020 Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and
Mihály Józsi +2 more
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Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway [PDF]
Frontiers in Immunology, 2020 Alternative complement pathway (AP) plays an important role in the development of sepsis, which is life threatening. Deficiency of factor H-related protein 1 (FHR-1), which is a regulator of AP, has been considered as a susceptible factor for atypical ...
Wei Li, Xiaorong Liu, Zhenhua Hao
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Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease [PDF]
Scientific Reports, 2021 Atherosclerotic cardiovascular disease (ACVD) is a lipid-driven inflammatory disease and one of the leading causes of death worldwide. Lipid deposits in the arterial wall lead to the formation of plaques that involve lipid oxidation, cellular necrosis ...
Sarah Irmscher +23 more
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Frontiers in Immunology, 2016 The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of hemolytic uremic syndrome (aHUS), whilst also found to be protective ...
Diana Pauly +2 more
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Factor H-Related 2 Levels Dictate FHR Dimer Composition
Scientific ReportsFactor H-related (FHR) protein 1 and 2 form dimers resulting in FHR-1 and -2 homodimers, and FHR-1/2 heterodimers. Dimerization is hypothesized to further increase their antagonistic function with complement regulator factor H (FH).
Karin van Leeuwen +2 more
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Frontiers in Immunology, 2017 The complement factor H-related (FHR) proteins are hypothesized to fine-tune the regulatory role of complement factor H (FH) in the alternative pathway of the complement system.
Karin van Leeuwen +2 more
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Impact of oxytocin discontinuation on fetal heart rate and uterine contractility: A pre‐specified ancillary analysis embedded within a randomized trial [PDF]
Acta Obstetricia et Gynecologica ScandinavicaIntroduction Oxytocin is widely used to augment uterine contractions during labor. However, its use has been associated with fetal heart rate (FHR) abnormalities and neonatal morbidity, which may be reduced by discontinuing oxytocin during labor.
Lise Lafforgue +7 more
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Evaluating the implementation of intermittent versus continuous fetal heart rate monitoring on intrapartum care and early neonatal outcomes using causal mediational modeling [PDF]
Frontiers in Drug Safety and RegulationIntroductionIntrapartum fetal heart rate (FHR) monitoring can detect fetal compromise and provide indications for early action. However, the effect of implementing intermittent vs. continuous FHR monitoring with Moyo remains unclear.
Omkar Basnet +8 more
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Identification of novel blood-borne soluble binding partners of factor H-related proteins [PDF]
Scientific ReportsThe deposition of circulating complement factor H-related (FHR) proteins in tissues around the body has been implicated in a series of complement-mediated diseases.
Jiaqi Tang +8 more
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Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces
Frontiers in Immunology, 2021 To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators.
Arthur Dopler +10 more
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