Results 11 to 20 of about 113,403,989 (177)

Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases. [PDF]

Blood, 2021
Abstract Factor H (FH)–related proteins are a group of partly characterized complement proteins thought to promote complement activation by competing with FH in binding to surface-bound C3b. Among them, FH-related protein 1 (FHR-1) is remarkable because of its association with atypical hemolytic uremic syndrome (aHUS) and other important
Martin Merinero H, Subías M, Pereda A, Gómez-Rubio E, Juana Lopez L, Fernandez C, Goicoechea de Jorge E, Martin-Santamaria S, Cañada FJ, Rodríguez de Córdoba S.   +9 more
europepmc   +5 more sources

FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation [PDF]

The Journal of Immunology, 2017
Abstract Factor H–related protein (FHR) 1 is one of the five human FHRs that share sequence and structural homology with the alternative pathway complement inhibitor FH. Genetic studies on disease associations and functional analyses indicate that FHR-1 enhances complement activation by competitive inhibition of FH binding to some ...
Ádám I Csincsi, Zsóka Szabó, Zsófia Bánlaki, Barbara Uzonyi, Marcell Cserhalmi, Éva Kárpáti, Agustín Tortajada, Joseph J E Caesar, Zoltán Prohászka, T Sakari Jokiranta, Susan M Lea, Santiago Rodríguez de Córdoba, Mihály Józsi   +12 more
core   +6 more sources

Die Funktion der Komplementproteine FHR-1 und FHR-3 bei der altersabhängigen Makuladegeneration – ein Antikörper-basierter Ansatz [PDF]

, 2021
Das humane Komplementsystem ist ein essentieller Teil der angeborenen Immunität, das aus einem präzise regulierten Zusammenspiel von über 40 löslichen und Membran-gebundenen Proteinen besteht. Der wichtigste Negativregulator des Komplementsystems ist Faktor H (FH).
Schäfer, Nicole
openaire   +2 more sources

The Murine Factor H-Related Protein FHR-B Promotes Complement Activation [PDF]

Frontiers in Immunology, 2017
Factor H-related (FHR) proteins consist of varying number of complement control protein domains that display various degrees of sequence identity to respective domains of the alternative pathway complement inhibitor factor H (FH). While such FHR proteins
Marcell Cserhalmi, Ádám I. Csincsi, Zoltán Mezei, Anne Kopp, Mario Hebecker, Barbara Uzonyi, Mihály Józsi   +6 more
doaj   +2 more sources

Functional and structural characterization of mouse Factor H-related B protein unveils a novel dimerization domain shared by FHR-B and FH [PDF]

Frontiers in Immunology
Factor H-related proteins (FHRs) are found in mice, but their equivalence to human FHRs remains uncertain. This study identifies three FHRs in mouse plasma (FHR-B, FHR-C, and FHR-E) and focuses on characterizing FHR-B.
Adrián Martín-Ambrosio Doménech, Silvia González Sanz, Bárbara Márquez Tirado, Lucia Juana-López, Elena Goicoechea de Jorge, Santiago Rodríguez de Córdoba, Héctor Martín Merinero   +6 more
doaj   +2 more sources

Fetal heart rate patterns associated with acidemia at fetal blood sampling during labor-An observational study. [PDF]

Acta Obstet Gynecol Scand
The Swedish fetal heart rate (FHR) classification from 2017 identifies most FHR patterns associated with fetal acidemia as non‐normal, according to fetal blood sampling (FBS) in immediate connection to the ongoing FHR pattern. However, long‐standing FHR patterns with non‐repetitive decelerations of the types severe variable and late warrant increased ...
Gyllencreutz E, Gröndal K, Malm D, Johansson K, Holzmann M.   +4 more
europepmc   +2 more sources

Complement Factor H Family Proteins Modulate Monocyte and Neutrophil Granulocyte Functions

Frontiers in Immunology, 2021
Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of complement has recently been emerging. Factor H (FH), the main regulator of the alternative pathway of complement activation, has been reported to bind to ...
Éva Kárpáti, Mariann Kremlitzka, Noémi Sándor, Noémi Sándor, Dávid Hajnal, Andrea E. Schneider, Mihály Józsi, Mihály Józsi   +7 more
doaj   +1 more source

Prediction value of first trimester ultrasound parameters for pregnancy outcome [PDF]

Zhenduanxue lilun yu shijian, 2021
Objective: To explore the predictive value of ultrasonographic parameters in the first trimester pregnancy outcomes. Methods: A total of 1 651 pregnancy were enrolled, and ultrasonographic parameters including fetal heart rate(FHR), mean gestation sac ...
CAO Yunyun, WANG Guanjie, ZENG Min, WANG Haifeng, NIU Jianmei, ZHOU Leiping
doaj   +1 more source

Leptospiral Immunoglobulin-like Proteins Interact With Human Complement Regulators Factor H, FHL-1, FHR-1, and C4BP [PDF]

The Journal of Infectious Diseases, 2012
Leptospira, the causative agent of leptospirosis, interacts with several host molecules, including extracellular matrix components, coagulation cascade proteins, and human complement regulators. Here we demonstrate that acquisition of factor H (FH) on the Leptospira surface is crucial for bacterial survival in the serum and that these spirochetes ...
Mónica Marcela, Castiblanco-Valencia, Tatiana Rodrigues, Fraga, Ludmila Bezerra da, Silva, Denize, Monaris, Patrícia Antônia Estima, Abreu, Stefanie, Strobel, Mihály, Józsi, Lourdes, Isaac, Angela Silva, Barbosa   +8 more
openaire   +2 more sources

Observing Water Surface Temperature from Two Different Airborne Platforms over Temporarily Flooded Wadden Areas at the Elbe Estuary—Methods for Corrections and Analysis

Remote Sensing, 2021
Over the Hahnöfer Nebenelbe, a part of the Elbe estuary near Hamburg, Germany, a combined aerial survey with an unmanned aerial system (UAV) and a gyrocopter was conducted to acquire information about the water surface temperatures. The water temperature
Katharina Fricke, Björn Baschek, Alexander Jenal, Caspar Kneer, Immanuel Weber, Jens Bongartz, Jens Wyrwa, Andreas Schöl   +7 more
doaj   +1 more source