Results 21 to 30 of about 113,403,989 (177)

Cutting Edge: FHR-1 Binding Impairs Factor H–Mediated Complement Evasion by the Malaria Parasite Plasmodium falciparum [PDF]

The Journal of Immunology, 2018
Abstract Human complement is the first line of defense against invading pathogens, including the malaria parasite Plasmodium falciparum. We previously demonstrated that human complement represents a particular threat for the clinically relevant blood stages of the parasite.
Timo Reiss, Thiago F de A Rosa, Katharina Blaesius, Rebecca P Bobbert, Peter F Zipfel, Christine Skerka, Gabriele Pradel   +6 more
openaire   +2 more sources

table_1_High Complement Factor H-Related (FHR)-3 Levels Are Associated With the Atypical Hemolytic-Uremic Syndrome-Risk Allele CFHR3*B.doc [PDF]

, 2020
Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a poor ...
Pilar Sánchez-Corral (5134376), Taco W. Kuijpers (7369328), Irene Gómez Delgado (5134373), Alberto López Lera (5134379), Santiago Rodríguez de Córdoba (8355621), Richard B. Pouw (8355618), Diana Wouters (369450)   +6 more
core   +3 more sources

The Efficacy of In-Phase and Quadrature Demodulation in Electronic Fetal Heart Rate Monitoring During Labor

Maternal-Fetal Medicine, 2022
. Objective:. To investigate the efficacy of in-phase and quadrature (IQ) demodulation in electronic fetal heart rate monitoring (EFM) to reduce false reports of fetal heart rate (FHR) doubling or halving. Methods:. This is a prospective cohort study.
Yiheng Liang, Ping Liu, Shaomei Yan, Yun Li, Duijin Chen, Shangrong Fan, Yang Pan   +6 more
doaj   +1 more source

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR levels and age-related macular degeneration [PDF]

, 2021
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus, encompassing the CFH and CFHR genes, but the underlying mechanisms ...
Bakker, Bjorn, Fauser, Sascha, van Mierlo, G., Jongerius, Ilse, Lores-Motta, L., Mary, J. L., Mary, Jean-Luc, Fauser, S., van Beek, Anna, de Jonge, Marien, Stucki, C., Clark, S. J., Koertvely, E., den Hollander, Anneke, Willems, E., Nogoceke, E., Bakker, B., Nogoceke, Everson, den Hollander, A. I., Kuijpers, Taco W., Hoyng, C. B., Clark, Simon; id_orcid, Jongerius, I., Koertvely, Elod, de Jonge, M. I., Kuijpers, Taco, Einhaus, A., van Beek, A. E., Kuijpers, T. W., Lorés-Motta, Laura, Zandstra, J., Stucki, Corinne, van Mierlo, Gerard, Einhaus, Alfred, Zandstra, Judith, Hoyng, Carel, Willems, Esther, Jonge, M.I. de, Beek, Anna E. van, Mierlo, Gerard van, Hoyng, C.B., Lores de Motta, L., Hollander, A.I. den, Marien I. de Jonge, Gerard van Mierlo, Anna E. van Beek, Everson Nogoceke, Alfred Einhaus, Anneke I. den Hollander, Elod Koertvely, Judith Zandstra, Bjorn Bakker, Taco W. Kuijpers, Simon J. Clark, Ilse Jongerius, Laura Lorés-Motta, Esther Willems, Corinne Stucki, Carel B. Hoyng, Sascha Fauser, Jean-Luc Mary   +60 more
core   +1 more source

Safety of Internal Electronic Fetal Heart Rate Monitoring During Labor

Maternal-Fetal Medicine, 2022
. Objective:. To investigate the safety and efficacy of internal electronic fetal heart rate (FHR) monitoring during labor. Methods:. This was a retrospective case-control study, which was an analysis of monitoring FHR with a fetal scalp electrode or a ...
Yiheng Liang, Yun Li, Chunhua Huang, Xiaohong Li, Qiaoqing Cai, Jiying Peng, Shangrong Fan, Yang Pan   +7 more
doaj   +1 more source

Agreement between cardiac cycle time intervals and myocardial velocities measured by automated analysis of color tissue Doppler cine loops and by manual tracing of spectral pulsed-wave tissue Doppler waveforms of sheep fetal heart under normal and pathological conditions: An experimental study. [PDF]

Acta Obstet Gynecol Scand
Automated cTDI in sheep fetuses provided reproducible measurements of myocardial velocities and heart rate that align well with manual pulsed‐wave TDI. For cardiac cycle duration metrics, the two modalities are not interchangeable. These findings support that automated cTDI is well suited for longitudinal assessment under both physiological and ...
Lantto J, Morena MG, Huhta H, Bhide A, Johnson J, Räsänen J, Acharya G.   +6 more
europepmc   +2 more sources

FHR-1, an additional human plasma protein, binds to complement regulator-acquiring surface proteins of Borrelia burgdorferi

International Journal of Medical Microbiology, 2008
The Borrelia burgdorferi strain LW2, a causative agent of Lyme disease, expresses up to five distinct complement regulator-acquiring surface proteins (CRASPs) that bind the human immune regulators factor H and/or FHL-1. In the present study, we identify FHR-1, a member of the human factor H protein family, as an additional ligand for CRASP-3, CRASP-4 ...
Katrin Haupt, Peter Kraiczy, Reinhard Wallich, Volker Brade, Christine Skerka, Peter F. Zipfel   +5 more
openaire   +1 more source

Beyond factor H:The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations [PDF]

, 2021
Age-related macular degeneration (AMD) is a leading cause of vision loss; there is strong genetic susceptibility at the complement factor H (CFH) locus. This locus encodes a series of complement regulators: factor H (FH), a splice variant factor-H-like 1
Clark, Simon J, Clark, Simon J; id_orcid, Tierney, Anna, Griffiths, John R, Cipriani, Valentina, Moore, Anthony T, Sergouniotis, Panagiotis, Unwin, Richard D; id_orcid, Yates, John RW, Sergouniotis, Panagiotis I, Bishop, Paul N, Yates, John R W, Unwin, Richard D, Zuber, Verena, Sergouniotis, Panagiotis I; id_orcid, Panagiotis I. Sergouniotis, John R.W. Yates, John R. Griffiths, Paul N. Bishop, Anthony T. Moore, Richard D. Unwin, Valentina Cipriani, Verena Zuber, Simon J. Clark, Anna Tierney   +24 more
core   +1 more source

Roles of parasympathetic outflow and sympathetic outflow in the cardiovascular response to brief umbilical cord occlusion in fetal sheep.

PLoS ONE, 2021
Fetal heart rate (FHR) deceleration is the most common change seen during labor. The role of the autonomic nervous system in regulating the fetal cardiovascular response during multiple uterine contractions has been well-established.
Morgan Recher, Arthur Lauriot Dit Prevost, Dyuti Sharma, Julien De Jonckheere, Charles Garabedian, Laurent Storme   +5 more
doaj   +1 more source

Fetal autonomic responses inferred from heart rate variability during recurrent decelerations without acidosis-An observational study. [PDF]

Int J Gynaecol Obstet
Abstract Objective Recurrent fetal heart rate (FHR) decelerations without acidosis are frequently observed during labor; however, the underlying autonomic mechanisms remain incompletely understood. This study explored fetal autonomic responses to recurrent decelerations using FHR and FHR variability (FHRV) parameters.
Magawa S, Nii M, Tamaishi Y, Okumura A, Takakura S, Maki S, Toriyabe K, Takayama E, Kondo E, Ikeda T.   +9 more
europepmc   +2 more sources